Sex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil

2009 ◽  
Vol 50 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Ricardo Cezar Torresan ◽  
Ana Teresa de Abreu Ramos-Cerqueira ◽  
Maria Alice de Mathis ◽  
Juliana Belo Diniz ◽  
Ygor Arzeno Ferrão ◽  
...  
Keyword(s):  
Sex Differences ◽  
Obsessive Compulsive Disorder ◽  
Exploratory Study ◽  
Phenotypic Expression ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Sex differences in the genetic architecture of obsessive-compulsive disorder

2018 ◽  
Vol 180 (6) ◽  
pp. 351-364 ◽  
Author(s):  
Ekaterina A. Khramtsova ◽  
Raphael Heldman ◽  
Eske M. Derks ◽  
Dongmei Yu ◽  
Lea K. Davis ◽  
...  
Keyword(s):  
Sex Differences ◽  
Obsessive Compulsive Disorder ◽  
Genetic Architecture ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Predicting Eating Disorder and Anxiety Symptoms Using Anorexia Nervosa and Obsessive-Compulsive Disorder Polygenic Scores

2020 ◽  
Author(s):  
Zeynep Yilmaz ◽  
Katherine Schaumberg ◽  
Matt Halvorsen ◽  
Erica L. Goodman ◽  
Leigh C. Brosof ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Sex Differences ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Obsessive Compulsive Disorder ◽  
Genetic Risk ◽  
Anxiety Symptoms ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Polygenic Scores

Clinical, epidemiological, and genetic findings support an overlap between eating disorders, obsessive-compulsive disorder (OCD), and anxiety symptoms. However, little research has examined the role of genetic factors in the expression of eating disorders and OCD/anxiety phenotypes. We examined whether the anorexia nervosa (AN), OCD, or AN/OCD transdiagnostic polygenic scores (PGS) predict eating disorders, OCD, and anxiety symptoms in a large population-based developmental cohort. Using summary statistics files from the Psychiatric Genomics Consortium Freeze 2 AN and Freeze 1 OCD GWAS, we first conducted an AN/OCD transdiagnostic GWAS meta-analysis and then calculated PGS for AN, OCD, and AN/OCD in participants from the Avon Longitudinal Study of Parents and Children with available genetic and phenotype data on eating disorder, OCD, and anxiety diagnoses and symptoms (sample size 3,212-5,369 per phenotype). We observed sex differences in the PGS prediction of eating disorder, OCD, and anxiety-related phenotypes, with AN genetic risk manifesting at an earlier age and playing a more prominent role in eating disorder phenotypes in boys than in girls. Compulsive exercise was the only phenotype predicted by all three PGS (e.g., PAN(boys)=0.0141 at age 14; POCD(girls)=0.0070 at age 16; PAN/OCD(all)=0.0297 at age 14). Our results suggest that earlier detection of eating disorder, OCD, and anxiety-related symptoms could be made possible by including measurement of genetic risk for these psychiatric conditions while being mindful of sex differences.

Sex differences in Indian patients with obsessive-compulsive disorder

2009 ◽  
Vol 50 (1) ◽  
pp. 70-75 ◽  
Author(s):  
T.S. Jaisoorya ◽  
Y.C. Janardhan Reddy ◽  
S. Srinath ◽  
K. Thennarasu
Keyword(s):  
Sex Differences ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Indian Patients

The role of the COMT Val158Met polymorphism in the phenotypic expression of obsessive-compulsive disorder

2009 ◽  
Vol 9999B ◽  
pp. n/a-n/a ◽  
Author(s):  
Hilga Katerberg ◽  
Danielle C. Cath ◽  
Damiaan A. J. P. Denys ◽  
Peter Heutink ◽  
Annemiek Polman ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Phenotypic Expression ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Comt Val158met ◽  
Val158met Polymorphism

Does Comorbid Attention-Deficit/Hyperactivity Disorder Impact the Clinical Expression of Pediatric Obsessive-Compulsive Disorder?

CNS Spectrums ◽  
2003 ◽  
Vol 8 (4) ◽  
pp. 259-264 ◽  
Author(s):  
Daniel A. Geller ◽  
Barbara Coffey ◽  
Stephen Faraone ◽  
Lisa Hagermoser ◽  
Noreen K. Zaman ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Obsessive Compulsive Disorder ◽  
Attention Deficit ◽  
Phenotypic Expression ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Clinical Correlates ◽  
Hyperactivity Disorder ◽  
Comorbid Adhd ◽  
The Impact

ABSTRACTWhat is the impact of attention-deficit/hyperactivity disorder (ADHD) on the phenotypic expression of pediatric obsessive-compulsive disorder (OCD). We examined phenotypic features, and functional and clinical correlates in youths with OCD, with and without comorbid ADHD, from a large sample of consecutively referred pediatric psychiatry patients. Although comorbid ADHD had no meaningful impact on the phenotypic expression or clinical correlates of OCD, it was associated with higher rates of compromised educational functioning compared with other OCD youths. Our findings suggest that the OCD phenotype runs true and is not impacted by comorbid ADHD in youths diagnosed with both OCD and ADHD. In such affected youths, both disorders contribute to morbid dysfunction and require treatment. More work is needed to determine whether OCD plus ADHD represents a developmentally and etiologically distinct form of the OCD syndrome.

Are There Sex Differences in Neuropsychological Functions Among Patients With Obsessive-Compulsive Disorder?

2006 ◽  
Vol 13 (1) ◽  
pp. 42-50 ◽  
Author(s):  
David Mataix-Cols ◽  
Qazi Rahman ◽  
Mary Spiller ◽  
Maria Pino Alonso ◽  
Josep Pifarre ◽  
...  
Keyword(s):  
Sex Differences ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Neuropsychological Functions
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