scholarly journals Sex differences in the genetic architecture of obsessive-compulsive disorder

2018 ◽  
Vol 180 (6) ◽  
pp. 351-364 ◽  
Author(s):  
Ekaterina A. Khramtsova ◽  
Raphael Heldman ◽  
Eske M. Derks ◽  
Dongmei Yu ◽  
Lea K. Davis ◽  
...  
Keyword(s):  
Sex Differences ◽  
Obsessive Compulsive Disorder ◽  
Genetic Architecture ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Predicting Eating Disorder and Anxiety Symptoms Using Anorexia Nervosa and Obsessive-Compulsive Disorder Polygenic Scores

2020 ◽  
Author(s):  
Zeynep Yilmaz ◽  
Katherine Schaumberg ◽  
Matt Halvorsen ◽  
Erica L. Goodman ◽  
Leigh C. Brosof ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Sex Differences ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Obsessive Compulsive Disorder ◽  
Genetic Risk ◽  
Anxiety Symptoms ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Polygenic Scores

Clinical, epidemiological, and genetic findings support an overlap between eating disorders, obsessive-compulsive disorder (OCD), and anxiety symptoms. However, little research has examined the role of genetic factors in the expression of eating disorders and OCD/anxiety phenotypes. We examined whether the anorexia nervosa (AN), OCD, or AN/OCD transdiagnostic polygenic scores (PGS) predict eating disorders, OCD, and anxiety symptoms in a large population-based developmental cohort. Using summary statistics files from the Psychiatric Genomics Consortium Freeze 2 AN and Freeze 1 OCD GWAS, we first conducted an AN/OCD transdiagnostic GWAS meta-analysis and then calculated PGS for AN, OCD, and AN/OCD in participants from the Avon Longitudinal Study of Parents and Children with available genetic and phenotype data on eating disorder, OCD, and anxiety diagnoses and symptoms (sample size 3,212-5,369 per phenotype). We observed sex differences in the PGS prediction of eating disorder, OCD, and anxiety-related phenotypes, with AN genetic risk manifesting at an earlier age and playing a more prominent role in eating disorder phenotypes in boys than in girls. Compulsive exercise was the only phenotype predicted by all three PGS (e.g., PAN(boys)=0.0141 at age 14; POCD(girls)=0.0070 at age 16; PAN/OCD(all)=0.0297 at age 14). Our results suggest that earlier detection of eating disorder, OCD, and anxiety-related symptoms could be made possible by including measurement of genetic risk for these psychiatric conditions while being mindful of sex differences.

Sex differences in Indian patients with obsessive-compulsive disorder

2009 ◽  
Vol 50 (1) ◽  
pp. 70-75 ◽  
Author(s):  
T.S. Jaisoorya ◽  
Y.C. Janardhan Reddy ◽  
S. Srinath ◽  
K. Thennarasu
Keyword(s):  
Sex Differences ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Indian Patients

Are There Sex Differences in Neuropsychological Functions Among Patients With Obsessive-Compulsive Disorder?

2006 ◽  
Vol 13 (1) ◽  
pp. 42-50 ◽  
Author(s):  
David Mataix-Cols ◽  
Qazi Rahman ◽  
Mary Spiller ◽  
Maria Pino Alonso ◽  
Josep Pifarre ◽  
...  
Keyword(s):  
Sex Differences ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Neuropsychological Functions

scholarly journals Sex differences in the genetic architecture of obsessive-compulsive disorder

2017 ◽  
Author(s):  
Ekaterina A. Khramtsova ◽  
Raphael Heldman ◽  
Eske M. Derks ◽  
Dongmei Yu ◽  
Lea K. Davis ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Obsessive Compulsive Disorder ◽  
Sex Difference ◽  
Genetic Architecture ◽  
Sexually Dimorphic ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Regulatory Variants ◽  
Specific Risk ◽  
Genome Wide

AbstractObsessive-compulsive disorder (OCD), a highly heritable complex phenotype, demonstrates sexual dimorphism in age of onset and clinical presentation, suggesting a possible sex difference in underlying genetic architecture. We present the first genome-wide characterization of the sex-specific genetic architecture of OCD, utilizing the largest set of OCD cases and controls available from the Psychiatric Genomics Consortium. We assessed evidence for several mechanisms that may contribute to sexual-dimorphism including a sexually dimorphic liability threshold, the presence of individual sex-specific risk variants on the autosomes and the X chromosome, genetic and phenotypic heterogeneity, and sex-specific pleiotropic effects. We observed a strong genetic correlation between male and female OCD and no evidence for a sexually dimorphic liability threshold model. While we did not detect any sex-specific genome-wide associations, we observed that the SNPs with sexually dimorphic effects showed an enrichment of regulatory variants influencing expression of genes in immune tissues. Furthermore, top sex-specific genome-wide associations were enriched for regulatory variants in different tissues, suggesting evidence for potential sex difference in the biology underlying risk for OCD. These findings suggest that future studies with larger sample sizes hold great promise for the identification of sex-specific risk factors for OCD, significantly advancing our understanding of the differences in the genetic basis of sexually dimorphic neuropsychiatric traits.

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