scholarly journals Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial

2020 ◽  
Author(s):  
Sadaf Oliai Araghi ◽  
Jessica C. Kiefte-de Jong ◽  
Suzanne C. van Dijk ◽  
Karin M.A. Swart ◽  
Kim J. Ploegmakers ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Folic Acid ◽  
Fracture Risk ◽  
Vitamin B12 ◽  
Long Term Effects ◽  
Vitamin B12 Supplementation

scholarly journals Long-term Effect of Folic Acid and Vitamin B12 Supplementation on Fracture Risk and Cardiovascular Disease: Follow-up Study of B-PROOF Trial (P24-031-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sadaf Oliai Araghi ◽  
Jessica C Kiefte-de Jong ◽  
Suzanne van Dijk ◽  
Natasja van Schoor ◽  
Lisette CPGM de Groot ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Folic Acid ◽  
Fracture Risk ◽  
Vitamin B12 ◽  
Homocysteine Level ◽  
Fracture Incidence ◽  
Total Homocysteine ◽  
The Hague ◽  
Vitamin B12 Supplementation

Abstract Objectives To investigate the possible effects of the intervention with folic acid and vitamin B12 supplementation on fracture and cardiovascular disease risk: 5–7 years after the end of the intervention period of 2–3 years. Methods Extended follow-up of B-PROOF trial, a multi-center, double-blind randomized placebo-controlled trial designed to assess the effect of 2–3 years daily supplementation with folic acid (400 µg) and vitamin-B12 (500 µg) versus placebo on fracture incidence. Fracture and cardiovascular outcomes were assessed by follow-up questionnaire. Fracture incidence (and a part of cardiovascular disease incidence) was verified by general practitioners (GPs). Results A total of 1298 individuals participated in the second follow-up round. Median age at baseline was 71.0 years [68.0–76.0] for both groups (n = 662 in the treatment group and n = 636 in the placebo group). No effect of the intervention on first osteoporotic fracture and other fracture risk after a follow up of 5–7 years was observed (HR: 0.99, 95% CI: 0.62; 1.59 and HR: 0.77; 95% CI: 0.50; 1.19, respectively) and also not for cardiovascular- or cerebrovascular disease (OR: 1.14; 95%CI: 0.74–1.74 and OR: 1.01; 95%CI: 0.76–1.33, respectively). Significant interaction for total homocysteine level was observed for osteoporotic- and any fracture (P = 0.10 and 0.06 resp.), which indicated a significantly lower risk of fracture in the intervention group with higher total homocysteine level. Conclusions This study does not support a prolonged effect of supplementation of folic acid and vitamin B12 on fracture risk, or on cardiovascular disease in older individuals with elevated homocysteine concentration. However, B-vitamin supplementation may be beneficial in reducing fractures in individuals with higher total homocysteine levels. Funding Sources The initial B-PROOF study has received funding so far by The Netherlands Organization for Health Research and Development (ZonMw), the Hague; unrestricted grant from NZO (Dutch Dairy Association), Zoetermeer; Orthica, Almere; NCHA (Netherlands Consortium Healthy Ageing) Leiden/Rotterdam; Ministry of Economic Affairs, Agriculture and Innovationn, the Hague; Wageningen University, Wageningen; VUmc, Amsterdam; Erasmus Medical Center, Rotterdam. Supporting Tables, Images and/or Graphs

scholarly journals Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial

2018 ◽  
Vol 28 (2) ◽  
pp. 275-282 ◽  
Author(s):  
Sadaf Oliai Araghi ◽  
Jessica C. Kiefte-de Jong ◽  
Suzanne C. van Dijk ◽  
Karin M.A. Swart ◽  
Hanneke W. van Laarhoven ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Osteoporotic Fractures ◽  
B Vitamins ◽  
Long Term Follow Up ◽  
Risk Of Cancer ◽  
Vitamin B12 Supplementation

scholarly journals Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)

BMJ ◽  
2007 ◽  
Vol 334 (7599) ◽  
pp. 885 ◽  
Author(s):  
Nancy R Cook ◽  
Jeffrey A Cutler ◽  
Eva Obarzanek ◽  
Julie E Buring ◽  
Kathryn M Rexrode ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Dietary Sodium ◽  
Sodium Reduction ◽  
Long Term Effects ◽  
Hypertension Prevention ◽  
Disease Outcomes

scholarly journals Funicular Myelosis in a Butcher: It Was the Cream Cans

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Fabian Wolpert ◽  
Krisztina Baráth ◽  
Janis Brakowski ◽  
Roland Renzel ◽  
Michael Linnebank ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Diagnostic Process ◽  
Long Term Effects ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation ◽  
Nutritional Vitamin

Background. Funicular myelosis is a known consequence of exposure to nitrous oxide. Nevertheless, there are only a few clinical trials assessing its long-term effects and there is no literature about the role of nutritional vitamin B12 supplementation in the context of nitrous oxide abuse.Case Descriptions. We diagnosed funicular myelosis in a young butcher, who consumed high amounts of meat regularly. Since the diagnostic process did not reveal any metabolic causes, reinterrogation of the patient uncovered recreational abuse of nitrous oxide out of whipped cream can gas cartridges. After stopping abuse and supplementation of vitamin B12, the patient recovered almost completely.Conclusions. In our case, even high nutritional vitamin B12 uptake could not compensate the noxious effects of nitrous oxide. Since there are emerging reports of increasing misuse, this should be considered in the diagnostic and therapeutic care of patients with nitrous oxide abuse. Furthermore, our case emphasizes that patients with vitamin B12 deficiency should be assessed for nitrous oxide abuse.

Hyperhomocysteinaemia and Vitamin B12 Deficiency: The Long-Term Effects in Cardiovascular Disease

Cardiology ◽  
2006 ◽  
Vol 107 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Martijn G.H. van Oijen ◽  
Floor Vlemmix ◽  
Robert J.F. Laheij ◽  
Lea Paloheimo ◽  
Jan B.M.J. Jansen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Long Term Effects ◽  
B12 Deficiency

scholarly journals The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Dieuwertje E. G. Kok ◽  
Rosalie A. M. Dhonukshe-Rutten ◽  
Carolien Lute ◽  
Sandra G. Heil ◽  
André G. Uitterlinden ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Elderly Subjects ◽  
Genome Wide ◽  
Vitamin B12 Supplementation
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