Hyperhomocysteinaemia and Vitamin B12 Deficiency: The Long-Term Effects in Cardiovascular Disease

Cardiology ◽  
2006 ◽  
Vol 107 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Martijn G.H. van Oijen ◽  
Floor Vlemmix ◽  
Robert J.F. Laheij ◽  
Lea Paloheimo ◽  
Jan B.M.J. Jansen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Long Term Effects ◽  
B12 Deficiency

scholarly journals Funicular Myelosis in a Butcher: It Was the Cream Cans

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Fabian Wolpert ◽  
Krisztina Baráth ◽  
Janis Brakowski ◽  
Roland Renzel ◽  
Michael Linnebank ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Diagnostic Process ◽  
Long Term Effects ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation ◽  
Nutritional Vitamin

Background. Funicular myelosis is a known consequence of exposure to nitrous oxide. Nevertheless, there are only a few clinical trials assessing its long-term effects and there is no literature about the role of nutritional vitamin B12 supplementation in the context of nitrous oxide abuse.Case Descriptions. We diagnosed funicular myelosis in a young butcher, who consumed high amounts of meat regularly. Since the diagnostic process did not reveal any metabolic causes, reinterrogation of the patient uncovered recreational abuse of nitrous oxide out of whipped cream can gas cartridges. After stopping abuse and supplementation of vitamin B12, the patient recovered almost completely.Conclusions. In our case, even high nutritional vitamin B12 uptake could not compensate the noxious effects of nitrous oxide. Since there are emerging reports of increasing misuse, this should be considered in the diagnostic and therapeutic care of patients with nitrous oxide abuse. Furthermore, our case emphasizes that patients with vitamin B12 deficiency should be assessed for nitrous oxide abuse.

scholarly journals Management of Peripheral Neuropathy and Cardiovascular Effects in Vitamin B12 Deficiency

2021 ◽  
Vol 10 (5) ◽  
Author(s):  
Nishant Kumar Singh ◽  
Hirni J. Patel ◽  
Mohit Buddhadev ◽  
S P Srinivas Nayak ◽  
Gunosindhu Chakraborthy
Keyword(s):  
Cardiovascular Disease ◽  
Peripheral Neuropathy ◽  
Vitamin B12 ◽  
Peripheral Nerves ◽  
Vitamin B12 Deficiency ◽  
Cardiovascular Effects ◽  
The Elderly ◽  
Vitamin Deficiencies ◽  
B12 Deficiency ◽  
Artery Disease

Peripheral nerves are susceptible to damage by a wide array of toxins, medications, and vitamin deficiencies. Vitamin B12 (VB12) deficiency neuropathy is a rare debilitating disease that affects mostly the elderly. It is important to consider these etiologies when approaching patients with a variety of neuropathic presentations in this review were have included most relevant and latest information on mechanisms causing Peripheral neuropathy in VB12 deficiency. We also have included cardiovascular disorders and their management. Hyperhomocysteinemia has been implicated in endothelial dysfunction and cardiovascular disease. The association of homocysteine (Hcy) and VB12 with cardiovascular risk factors in patients with coronary artery disease (CAD) has also been studied Keywords: Peripheral Neuropathy, Vitamin B12 Deficiency, Cardiovascular Disease and Homocysteine.

Analiza obrazu klinicznego niedokrwistości z niedoboru witaminy B12 u dzieci

2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Aleksandra Pankiewicz ◽  
Anna Adamowicz-Salach ◽  
Marek W. Karwacki ◽  
Katarzyna Pawelec ◽  
Katarzyna Albrecht ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Metabolic Pathways ◽  
Essential Role ◽  
Vitamin B12 Deficiency ◽  
Neurological Damage ◽  
Laboratory Findings ◽  
Delay In Diagnosis ◽  
B12 Deficiency ◽  
Late Manifestation

Diagnosis of vitamin B12 deficiency could be difficult due to various and rather unspecific symptoms and often late manifestation in hematological findings. B12 has a crucial role as cofactor of many metabolic pathways and has essential role in many processes such as DNA synthesis, neuron myelination and gluconeogenesis. Blood smear has a huge role in early diagnosis and should be performed. B12 deficiency is not very common, however could be underestimated especially in developing countries. In children main cause of deficiency is exclusively breastfeeding by vitamin B12 depleted mothers. Consequences of low intake in children are more severe than in adults, because of lower liver storage. Early detection and treatment is very important, because long term deficiency could result in persistent neurological damage. Coexistence iron or folate deficiencies could result delay in diagnosis. In this article different manifestation and laboratory findings in group of children with B12 deficiency is described.

scholarly journals Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial

2020 ◽  
Author(s):  
Sadaf Oliai Araghi ◽  
Jessica C. Kiefte-de Jong ◽  
Suzanne C. van Dijk ◽  
Karin M.A. Swart ◽  
Kim J. Ploegmakers ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Folic Acid ◽  
Fracture Risk ◽  
Vitamin B12 ◽  
Long Term Effects ◽  
Vitamin B12 Supplementation

scholarly journals Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

2016 ◽  
Vol 101 (4) ◽  
pp. 1754-1761 ◽  
Author(s):  
Vanita R. Aroda ◽  
Sharon L. Edelstein ◽  
Ronald B. Goldberg ◽  
William C. Knowler ◽  
Santica M. Marcovina ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Prevention Program ◽  
Diabetes Prevention ◽  
Vitamin B12 Deficiency ◽  
Diabetes Prevention Program ◽  
Open Label ◽  
Metformin Group ◽  
B12 Deficiency ◽  
Outcomes Study

Abstract Context: Vitamin B12 deficiency may occur with metformin treatment, but few studies have assessed risk with long-term use. Objective: To assess the risk of B12 deficiency with metformin use in the Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS). Design: Secondary analysis from the DPP/DPPOS. Participants were assigned to the placebo group (PLA) (n = 1082) or the metformin group (MET) (n = 1073) for 3.2 years; subjects in the metformin group received open-label metformin for an additional 9 years. Setting: Twenty-seven study centers in the United States. Patients: DPP eligibility criteria were: elevated fasting glucose, impaired glucose tolerance, and overweight/obesity. The analytic population comprised participants with available stored samples. B12 levels were assessed at 5 years (n = 857, n = 858) and 13 years (n = 756, n = 764) in PLA and MET, respectively. Interventions: Metformin 850 mg twice daily vs placebo (DPP), and open-label metformin in the metformin group (DPPOS). Main Outcome Measures: B12 deficiency, anemia, and peripheral neuropathy. Results: Low B12 (≤ 203 pg/mL) occurred more often in MET than PLA at 5 years (4.3 vs 2.3%; P = .02) but not at 13 years (7.4 vs 5.4%; P = .12). Combined low and borderline-low B12 (≤ 298 pg/mL) was more common in MET at 5 years (19.1 vs 9.5%; P < .01) and 13 years (20.3 vs 15.6%; P = .02). Years of metformin use were associated with increased risk of B12 deficiency (odds ratio, B12 deficiency/year metformin use, 1.13; 95% confidence interval, 1.06–1.20). Anemia prevalence was higher in MET, but did not differ by B12 status. Neuropathy prevalence was higher in MET with low B12 levels. Conclusions: Long-term use of metformin in DPPOS was associated with biochemical B12 deficiency and anemia. Routine testing of vitamin B12 levels in metformin-treated patients should be considered.

Neuropsychological Profiles of Children Following Vitamin B12 Deficiency During Infancy: A Case Series

2016 ◽  
Vol 17 (3) ◽  
pp. 242-253
Author(s):  
M. Greenham ◽  
V. Anderson ◽  
J. Campbell ◽  
P. Monagle ◽  
M.H. Beauchamp
Keyword(s):  
Vitamin B12 ◽  
Case Series ◽  
Vitamin B12 Deficiency ◽  
Brain Maturation ◽  
Attention And Memory ◽  
Long Term Outcomes ◽  
Retrospective Case ◽  
School Aged Children ◽  
B12 Deficiency

Previous studies investigating long-term outcomes in children following vitamin B12 deficiency during infancy have been limited to IQ or clinical observation. This paper seeks to describe comprehensive neuropsychological profiles in a case series of school-aged children who were treated for infantile vitamin B12 deficiency. This was a retrospective case series of seven children who were treated for vitamin B12 deficiency during infancy and aged 5 to 16 years at the time of testing. While most children had age-expected intellectual performance, the distribution of the sample was skewed to the lower end of the normal range. Furthermore, children were found to have impairments in a number of neuropsychological domains, most common were attention and memory, followed by executive function. These results suggest that while neurological symptoms quickly resolve following treatment, these effects on early brain development may disrupt brain maturation and have the potential to impact on later development.

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