scholarly journals Funicular Myelosis in a Butcher: It Was the Cream Cans

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Fabian Wolpert ◽  
Krisztina Baráth ◽  
Janis Brakowski ◽  
Roland Renzel ◽  
Michael Linnebank ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Diagnostic Process ◽  
Long Term Effects ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation ◽  
Nutritional Vitamin

Background. Funicular myelosis is a known consequence of exposure to nitrous oxide. Nevertheless, there are only a few clinical trials assessing its long-term effects and there is no literature about the role of nutritional vitamin B12 supplementation in the context of nitrous oxide abuse.Case Descriptions. We diagnosed funicular myelosis in a young butcher, who consumed high amounts of meat regularly. Since the diagnostic process did not reveal any metabolic causes, reinterrogation of the patient uncovered recreational abuse of nitrous oxide out of whipped cream can gas cartridges. After stopping abuse and supplementation of vitamin B12, the patient recovered almost completely.Conclusions. In our case, even high nutritional vitamin B12 uptake could not compensate the noxious effects of nitrous oxide. Since there are emerging reports of increasing misuse, this should be considered in the diagnostic and therapeutic care of patients with nitrous oxide abuse. Furthermore, our case emphasizes that patients with vitamin B12 deficiency should be assessed for nitrous oxide abuse.

scholarly journals Long-term outcome in children with nutritional vitamin B12 deficiency

2011 ◽  
Vol 2011 (4) ◽  
pp. 286-293 ◽  
Author(s):  
Melike Sezgin Evim ◽  
Sahin Erdol ◽  
Ozlem Ozdemir ◽  
Birol Baytan
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Term Outcome ◽  
Long Term Outcome ◽  
B12 Deficiency ◽  
Nutritional Vitamin

Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants

1992 ◽  
Vol 121 (5) ◽  
pp. 710-714 ◽  
Author(s):  
Stephen M. Graham ◽  
Otto M. Arvela ◽  
Graham A. Wise
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency ◽  
Nutritional Vitamin

scholarly journals Vitamin B12 and Holotranscobalamin Levels in Diabetic Peripheral Neuropathy Patients

2016 ◽  
Vol 20 (1) ◽  
pp. 16-20
Author(s):  
Mohammed Noorjahan ◽  
Kandregula Madhavi ◽  
Chandran Priscilla ◽  
Shaik A Jabeen
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Vitamin B12 ◽  
Diabetic Peripheral Neuropathy ◽  
Vitamin B12 Deficiency ◽  
Biologically Active ◽  
Significant Difference ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation

ABSTRACT Diabetic neuropathy is the most common and debilitating microvascular complication leading to nontraumatic amputations. Identifying the role of vitamin B12 in the etiology of neuropathy is crucial because simple vitamin B12 replacement may reverse neurologic symptoms if confirmed. Large proportion of vegetarians and patients on metformin have been associated with lowering of vitamin B12 levels. We have undertaken study on 60 vegetarian subjects between the age of 30 and 60 years, 20 healthy controls, 20 type 2 diabetes mellitus patients who were on metformin with peripheral neuropathy (DMWN), and 20 diabetics without peripheral neuropathy (DMWON). Vitamin B12, homocysteine, and folate levels were measured, and holotranscobalamin (holoTC) is also included, to improve the diagnosis of tissue vitamin B12 status, as holoTC is the biologically active fraction and more sensitive index of vitamin B12 status than total vitamin B12 itself. Complete history and clinical evaluation for neuropathy and electroneuromyography were recorded. Results In the DMWN group, vitamin B12 levels were significantly higher than in the DMWON group and controls [1013 (564-1501) pmol/l, 387 (245-731) pmol/l, and 305 (234-472) pmol/l respectively]. Similarly, serum holoTC was also found to be significantly higher in the DMWN [203.8 (129-300) pmol/l] group compared with the DMWON [94.4 (42.2-230.6) pmol/l] group and controls [74 (40-170) pmol/l]. Whereas mean levels of homocysteine and folate did not show any significant difference between groups, significant increase in fasting blood sugar and HbA1c was seen in the DMWN group compared with DMWON group and controls. Duration of diabetes is also significantly more in DMWN group compared with DMWON group. Conclusion We found that vitamin B12 and holoTC levels were high in patients with DMWN and DMWON groups compared with controls. Our study demonstrated that peripheral neuropathy was not associated with vitamin B12 deficiency in diabetics. These findings merit further research on a larger population to investigate into the cause of diabetic neuropathy, the factors involved, and benefit of vitamin B12 supplementation in these patients. Key messages Vitamin B12 status has no association with diabetic peripheral neuropathy. How to cite this article Noorjahan M, Madhavi K, Priscilla C, Jabeen SA. Vitamin B12 and Holotranscobalamin Levels in Diabetic Peripheral Neuropathy Patients. Indian J Med Biochem 2016;20(1):16-20.

scholarly journals P-OGC11 Vitamin B12 supplementation post gastrectomy. A service audit in St. James’s hospital, Dublin

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Hugo Temperley ◽  
Cian Murray ◽  
James Carey ◽  
Jarlath Bolger ◽  
Narayanasamy Ravi ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Total Gastrectomy ◽  
Cell Mass ◽  
Subtotal Gastrectomy ◽  
Vitamin B12 Deficiency ◽  
Patient Understanding ◽  
Phone Calls ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation

Abstract Background Vitamin B12 deficiency is a well described complication post gastrectomy. It is caused by the loss of parietal cell mass leading to megaloblastic anaemia and possible long term neurological symptoms. Treatment can be with standardised replacement regimens or to monitor B12 levels and replace as required.  This study assesses patient understanding of and compliance with B12 supplementation guidelines post total and subtotal gastrectomy.  Methods 125 patients who underwent gastrectomy between 2010-2020 were available for study (86 total gastrectomies, 39 subtotal gastrectomies).  Patient data was collected by review of the hospital electronic records and individual phone calls. Patients were asked standardised questions to elicit knowledge of the importance of B12 supplementation and compliance with supplementation. Results 92% (79/86) of total gastrectomy patients reported compliance in regular parenteral B12 supplementation.  Compliance was significantly lower for subtotal gastrectomies  for checking and/or replacing their vitamin B12 at 53.8% (21/39) (p < 0.001). 62.6% of patients stated that they knew it was important to supplement B12 post gastrectomy.  37.8% of participants could explain why this was important and 14.8% had any knowledge of the complications of vitamin B12 deficiency. Patients who were compliant with B12 supplementation had an improved understanding of why supplementation was important compared to those who did not. Conclusions Regular monitoring and supplementation of vitamin B12 levels is important post gastrectomy.  This study demonstrates good compliance in those undergoing total gastrectomy.  Patient understanding correlates with compliance, suggesting that patient education and knowledge reinforcement may be key to compliance with vitamin B12 supplementation.

Hyperhomocysteinaemia and Vitamin B12 Deficiency: The Long-Term Effects in Cardiovascular Disease

Cardiology ◽  
2006 ◽  
Vol 107 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Martijn G.H. van Oijen ◽  
Floor Vlemmix ◽  
Robert J.F. Laheij ◽  
Lea Paloheimo ◽  
Jan B.M.J. Jansen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Long Term Effects ◽  
B12 Deficiency

scholarly journals Microangiopathic haemolytic anaemia with thrombocytopenia induced by vitamin B12 deficiency long term after gastrectomy

2018 ◽  
pp. bcr-2018-225915 ◽  
Author(s):  
Yukinori Harada ◽  
Itsumi Komori ◽  
Kouhei Morinaga ◽  
Taro Shimizu
Keyword(s):  
Vitamin B12 ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Haemolytic Anaemia ◽  
Vitamin B12 Deficiency ◽  
Rapid Progression ◽  
Thrombocytopenic Purpura ◽  
Microangiopathic Haemolytic Anaemia ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation

Microangiopathic haemolytic anaemia with thrombocytopenia, called pseudo-thrombotic microangiopathy (TMA), is a clinically important complication in patients with vitamin B12 deficiency. We herein present a case of an 80-year-old woman with pseudo-TMA after gastrectomy. She was initially suspected with thrombotic thrombocytopenic purpura based on rapid progression of anaemia with schistocytes and thrombocytopenia; however, her anaemia and thrombocytopenia were improved by vitamin B12 supplementation alone, with a single session of plasma exchange. Vitamin B12 deficiency was finally confirmed by low vitamin B12 levels from the patient’s initial blood sample. In addition, normal ADAMTS13 activity was proven, lowering the likelihood of thrombotic thrombocytopenic purpura. Therefore, this patient was diagnosed with pseudo-TMA caused by vitamin B12 deficiency. Pseudo-TMA can occur in patients with vitamin B12 deficiency post-gastrectomy.

Vitamin B12 Deficiency an Unusual Cause of Fever: A Case Report

2019 ◽  
Vol 4 (02) ◽  
Author(s):  
Shyama . ◽  
P. Kumar ◽  
Surabhi .
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Unusual Case ◽  
Vitamin B12 Deficiency ◽  
Bone Marrow Aspiration ◽  
Microcytic Anemia ◽  
Peripheral Smear ◽  
Erythroid Hyperplasia ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation

Introduction: An unusual case of a 19 year old female, presenting with fever, pallor and hepatosplenomegaly for one month. She had microcytic anemia on peripheral smear examination but her bone marrow aspiration & biopsy revealed a hypercelluar marrow with megaloblastic erythroid hyperplasia. Resolution of fever within 48 hours of Vitamin B12 supplementation, initiated in view of the megaloblastic bone marrow picture & low serumVitamin B12 level, suggests a causal association. Conclusion: Vitamin B12 deficiency seems to be an unusual cause of PUO (Pyrexia of unkown origin) which should be ruled out in every case of PUO.

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