scholarly journals Understanding the biology of HER3 receptor as a therapeutic target in human cancer

2018 ◽  
Vol 8 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Hui Lyu ◽  
Amy Han ◽  
Erik Polsdofer ◽  
Shuang Liu ◽  
Bolin Liu
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Her3 Receptor

ADAMTS9-AS2: A functional long non-coding RNA in tumorigenesis

2021 ◽  
Vol 27 ◽  
Author(s):  
Wen Xu ◽  
Bei Wang ◽  
Yuxuan Cai ◽  
Jinlan Chen ◽  
Xing Lv ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Signaling Pathways ◽  
Therapeutic Target ◽  
Molecular Mechanisms ◽  
Human Cancer ◽  
Migration Inhibition ◽  
Cancer Proliferation ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Long Non Coding Rna

Background: Long non-coding RNAs (lncRNA) have been identified as novel molecular regulators in cancers. LncRNA ADAMTS9-AS2 can mediate the occurrence and development of cancer through various ways such as regulating miRNAs, activating the classical signaling pathways in cancer, and so on, which have been studied by many scholars. In this review, we summarize the molecular mechanisms of ADAMTS9-AS2 in different human cancers. Methods: Through a systematic search of PubMed, lncRNA ADAMTS9-AS2 mediated molecular mechanisms in cancer are summarized inductively. Results: ADAMTS9-AS2 aberrantly expression in different cancers is closely related to cancer proliferation, invasion, migration, inhibition of apoptosis. The involvement of ADAMTS9-AS2 in DNA methylation, mediating PI3K / Akt / mTOR signaling pathways, regulating miRNAs and proteins, and such shows its significant potential as a therapeutic cancer target. Conclusion: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.

Dysregulation of miRNA in cancer progression

2021 ◽  
Author(s):  
Rucha P.
Keyword(s):  
Gene Regulation ◽  
Cancer Progression ◽  
Therapeutic Target ◽  
Chromosomal Abnormalities ◽  
Human Cancer ◽  
Epigenetic Modification ◽  
Therapeutic Applications ◽  
Non Coding Rnas ◽  
Transcriptional Gene Regulation

MicroRNAs (miRNAs) are a category of highly conserved tiny non-coding RNAs that play a role in post-transcriptional gene regulation. Numerous studies have shown the role of dysregulated miRNA in a variety of illnesses, including human cancer. MiRNA is dysregulated by a variety of processes, including dysregulation of miRNA synthesis, aberrant miRNA transcription, dysregulated epigenetic modification, and chromosomal abnormalities. MiRNAs that are overexpressed have been shown to influence cancer's hallmarks. Recent research has shown miRNA's potential as a therapeutic target and biomarker. In this review, we discussed the synthesis and regulation of miRNA, as well as its dysregulation in human cancer and other disorders, as well as some of the therapeutic applications of miRNA.

The Myc oncoprotein as a therapeutic target for human cancer

2006 ◽  
Vol 16 (4) ◽  
pp. 318-330 ◽  
Author(s):  
Marina Vita ◽  
Marie Henriksson
Keyword(s):  
Therapeutic Target ◽  
Human Cancer

scholarly journals The MEK/ERK Network as a Therapeutic Target in Human Cancer

2020 ◽  
pp. molcanres.0687.2020
Author(s):  
Renee Barbosa ◽  
Lucila A Acevedo ◽  
Ronen Marmorstein
Keyword(s):  
Therapeutic Target ◽  
Human Cancer

scholarly journals Hypoxic Regulation of Neutrophils in Cancer

2019 ◽  
Vol 20 (17) ◽  
pp. 4189 ◽  
Author(s):  
Daniel Triner ◽  
Yatrik M. Shah
Keyword(s):  
Transcription Factors ◽  
Therapeutic Target ◽  
Human Cancer ◽  
Critical Role ◽  
Neutrophil Function ◽  
Neoplastic Progression ◽  
Specific Expression ◽  
Microbial Response ◽  
Novel Therapeutic

Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating neutrophil function in tumors. Furthermore, neutrophil-specific expression of hypoxia-inducible transcription factors may represent a novel therapeutic target for human cancer. In this review, we highlight the function of neutrophils in cancer and the role of the neutrophil hypoxic response in regulating the neoplastic progression of cancer.

scholarly journals MicroRNA-34a: a potential therapeutic target in human cancer

2014 ◽  
Vol 5 (7) ◽  
pp. e1327-e1327 ◽  
Author(s):  
X J Li ◽  
Z J Ren ◽  
J H Tang
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Potential Therapeutic Target

scholarly journals BMI-1, a promising therapeutic target for human cancer

2015 ◽  
Vol 10 (2) ◽  
pp. 583-588 ◽  
Author(s):  
MIN-CONG WANG ◽  
CHUN-LI LI ◽  
JIE CUI ◽  
MIN JIAO ◽  
TAO WU ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Promising Therapeutic Target
Sign in / Sign up

Export Citation Format

Share Document