scholarly journals BMI-1, a promising therapeutic target for human cancer

2015 ◽  
Vol 10 (2) ◽  
pp. 583-588 ◽  
Author(s):  
MIN-CONG WANG ◽  
CHUN-LI LI ◽  
JIE CUI ◽  
MIN JIAO ◽  
TAO WU ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Promising Therapeutic Target

KRAS: A Promising Therapeutic Target for Cancer Treatment

2019 ◽  
Vol 19 (23) ◽  
pp. 2081-2097 ◽  
Author(s):  
Hai-Zhou Wu ◽  
Jia-Qi Xiao ◽  
Song-Shu Xiao ◽  
Yan Cheng
Keyword(s):  
Rna Interference ◽  
Virtual Screening ◽  
Therapeutic Target ◽  
Synthetic Lethality ◽  
Human Cancer ◽  
Promising Therapeutic Target ◽  
Direct Targeting ◽  
Experimental Strategies ◽  
Virtual Screening Approach ◽  
Viral Oncogene Homolog

: Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. Scientists have not successfully developed drugs that target KRAS, although efforts have been made last three decades. In this review, we highlight the emerging experimental strategies of impairing KRAS membrane localization and the direct targeting of KRAS. We also conclude the combinatorial therapies and RNA interference technology for the treatment of KRAS mutant cancers. Moreover, the virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1 G93G Mice Predates Disease Onset and is a Promising Therapeutic Target

2019 ◽  
Author(s):  
Silvia Scaricamazza ◽  
Illari Salvatori ◽  
Giacomo Giacovazzo ◽  
Jean Philippe Loeffler ◽  
Frederique Renè ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Therapeutic Target ◽  
Disease Onset ◽  
Metabolic Reprogramming ◽  
Promising Therapeutic Target

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

2021 ◽  
Author(s):  
Johannes Burtscher ◽  
Muhammed Muazzam Kamil Syed ◽  
Hilal A. Lashuel ◽  
Grégoire P. Millet
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target ◽  
Promising Therapeutic Target

scholarly journals HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia

2020 ◽  
Vol 8 ◽  
Author(s):  
Marco Spreafico ◽  
Alicja M. Gruszka ◽  
Debora Valli ◽  
Mara Mazzola ◽  
Gianluca Deflorian ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Therapeutic Target ◽  
Myeloid Leukemia ◽  
Promising Therapeutic Target ◽  
Acute Myeloid

Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers

2014 ◽  
Vol 18 (4) ◽  
pp. 403-414 ◽  
Author(s):  
Shinya Matsuzaki ◽  
Satoshi Serada ◽  
Akiko Morimoto ◽  
Yutaka Ueda ◽  
Kiyoshi Yoshino ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Annexin A4 ◽  
Platinum Resistant ◽  
Promising Therapeutic Target

Design and evaluation of IKK-activated GSK3 inhibitory peptide as an inflammation-responsive anti-colitic therapeutics

2021 ◽  
Author(s):  
Sungchae Hong ◽  
Sanghyun Ju ◽  
Jin-Wook Yoo ◽  
Nam-Chul Ha ◽  
Yunjin Jung
Keyword(s):  
Therapeutic Target ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Inhibitory Peptide ◽  
Promising Therapeutic Target

Glycogen synthase kinase-3β (GSK3β), a multi-functional kinase, is a promising therapeutic target for the treatment of inflammation. Inhibitory B kinase (IKK)-activated GSK3β inhibitory peptide (IAGIP) was designed as an inflammation-responsive...

ADAMTS9-AS2: A functional long non-coding RNA in tumorigenesis

2021 ◽  
Vol 27 ◽  
Author(s):  
Wen Xu ◽  
Bei Wang ◽  
Yuxuan Cai ◽  
Jinlan Chen ◽  
Xing Lv ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Signaling Pathways ◽  
Therapeutic Target ◽  
Molecular Mechanisms ◽  
Human Cancer ◽  
Migration Inhibition ◽  
Cancer Proliferation ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Long Non Coding Rna

Background: Long non-coding RNAs (lncRNA) have been identified as novel molecular regulators in cancers. LncRNA ADAMTS9-AS2 can mediate the occurrence and development of cancer through various ways such as regulating miRNAs, activating the classical signaling pathways in cancer, and so on, which have been studied by many scholars. In this review, we summarize the molecular mechanisms of ADAMTS9-AS2 in different human cancers. Methods: Through a systematic search of PubMed, lncRNA ADAMTS9-AS2 mediated molecular mechanisms in cancer are summarized inductively. Results: ADAMTS9-AS2 aberrantly expression in different cancers is closely related to cancer proliferation, invasion, migration, inhibition of apoptosis. The involvement of ADAMTS9-AS2 in DNA methylation, mediating PI3K / Akt / mTOR signaling pathways, regulating miRNAs and proteins, and such shows its significant potential as a therapeutic cancer target. Conclusion: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.

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