scholarly journals MicroRNA-34a: a potential therapeutic target in human cancer

2014 ◽  
Vol 5 (7) ◽  
pp. e1327-e1327 ◽  
Author(s):  
X J Li ◽  
Z J Ren ◽  
J H Tang
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Potential Therapeutic Target

Nrf2 is a potential therapeutic target in radioresistance in human cancer

2013 ◽  
Vol 88 (3) ◽  
pp. 706-715 ◽  
Author(s):  
Suna Zhou ◽  
Wenguang Ye ◽  
Qiuju Shao ◽  
Mingxin Zhang ◽  
Jun Liang
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Potential Therapeutic Target

scholarly journals SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer

2019 ◽  
Vol 9 ◽  
Author(s):  
Suraksha Tamang ◽  
Varnali Acharya ◽  
Deepronil Roy ◽  
Rinka Sharma ◽  
Apeksha Aryaa ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Potential Therapeutic Target

scholarly journals RNF6 as an Oncogene and Potential Therapeutic Target—A Review

BioTech ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 22
Author(s):  
Paweł Zapolnik ◽  
Antoni Pyrkosz
Keyword(s):  
Ubiquitin Ligase ◽  
Therapeutic Target ◽  
Human Cancer ◽  
Ring Finger ◽  
Model Organisms ◽  
Ring Finger Protein ◽  
Potential Therapeutic Target ◽  
Finger Protein ◽  
Potential Prognostic Factor

The RNF6 gene encodes Ring Finger Protein 6 (RNF6), which functions as a ubiquitin ligase. Its functions are not entirely known, but research shows that it is involved in human cancer development. Initially, this gene was considered to be a tumor suppressor. Numerous statistical analyses on cell lines and animals indicate, however, that RNF6 functions as an oncogene, involved in signaling pathways, including SHP1/STAT3, AKT/mTOR, Wnt/β-catenin, or ERα/Bcl-xL. Due to this fact, it has become a potential prognostic factor and therapeutic target. Studies in tumor cells and model organisms using inhibitors such as total saponins from Paris forrestii (TSPf), ellagic acid, or microRNA molecules show the effectiveness of inhibiting RNF6, and through it, the pathways of tumor cell proliferation. The results of the currently available studies are promising, but the function of RNF6 is not fully understood. More research is needed to assess the role of RNF6 and to check the safety and efficacy of inhibitors.

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