scholarly journals Hypoxic Regulation of Neutrophils in Cancer

2019 ◽  
Vol 20 (17) ◽  
pp. 4189 ◽  
Author(s):  
Daniel Triner ◽  
Yatrik M. Shah
Keyword(s):  
Transcription Factors ◽  
Therapeutic Target ◽  
Human Cancer ◽  
Critical Role ◽  
Neutrophil Function ◽  
Neoplastic Progression ◽  
Specific Expression ◽  
Microbial Response ◽  
Novel Therapeutic

Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating neutrophil function in tumors. Furthermore, neutrophil-specific expression of hypoxia-inducible transcription factors may represent a novel therapeutic target for human cancer. In this review, we highlight the function of neutrophils in cancer and the role of the neutrophil hypoxic response in regulating the neoplastic progression of cancer.

scholarly journals Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation

Blood ◽  
2013 ◽  
Vol 122 (3) ◽  
pp. 443-455 ◽  
Author(s):  
Guoqi Zhang ◽  
Li Yang ◽  
Gab Seok Kim ◽  
Kieran Ryan ◽  
Shulin Lu ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Therapeutic Target ◽  
Vascular Inflammation ◽  
Critical Role ◽  
Vascular Disorders ◽  
Vascular Integrity ◽  
Key Points ◽  
Sphingosine 1 Phosphate ◽  
Novel Therapeutic

Key Points Endothelial S1PR2 plays a critical role in the induction of vascular permeability and vascular inflammation during endotoxemia. S1PR2 could be a novel therapeutic target to promote vascular integrity in inflammatory vascular disorders.

Dysregulation of miRNA in cancer progression

2021 ◽  
Author(s):  
Rucha P.
Keyword(s):  
Gene Regulation ◽  
Cancer Progression ◽  
Therapeutic Target ◽  
Chromosomal Abnormalities ◽  
Human Cancer ◽  
Epigenetic Modification ◽  
Therapeutic Applications ◽  
Non Coding Rnas ◽  
Transcriptional Gene Regulation

MicroRNAs (miRNAs) are a category of highly conserved tiny non-coding RNAs that play a role in post-transcriptional gene regulation. Numerous studies have shown the role of dysregulated miRNA in a variety of illnesses, including human cancer. MiRNA is dysregulated by a variety of processes, including dysregulation of miRNA synthesis, aberrant miRNA transcription, dysregulated epigenetic modification, and chromosomal abnormalities. MiRNAs that are overexpressed have been shown to influence cancer's hallmarks. Recent research has shown miRNA's potential as a therapeutic target and biomarker. In this review, we discussed the synthesis and regulation of miRNA, as well as its dysregulation in human cancer and other disorders, as well as some of the therapeutic applications of miRNA.

Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease

2020 ◽  
pp. 212-234
Author(s):  
Mansi Verma ◽  
Sujata Basu ◽  
Manisha Singh ◽  
Rachana R. ◽  
Simrat Kaur ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Molecular Interactions ◽  
Therapeutic Target ◽  
Molecular Mechanisms ◽  
Degradation Pathways ◽  
Functional Changes ◽  
The World ◽  
Novel Therapeutic

Parkinson's disease (PD) has been reported to be the most common neurodegenerative diseases all over the world. Several proteins are associated and responsible for causing PD. One such protein is α-synuclein. This chapter discusses the role of α-synuclein in PD. Various genetic and epigenetic factors, which cause structural and functional changes for α-synuclein, have been described. Several molecular mechanisms, which are involved in regulating mitochondrial and lysosomal related pathways and are linked to α-synuclein, have been discussed in detail. The knowledge gathered is further discussed in terms of using α-synuclein as a diagnostic marker for PD and as a novel therapeutic target for the same.

scholarly journals The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis

2020 ◽  
Vol 29 (157) ◽  
pp. 200269
Author(s):  
Manuela Platé ◽  
Delphine Guillotin ◽  
Rachel C Chambers
Keyword(s):  
Extracellular Matrix ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Therapeutic Target ◽  
Critical Role ◽  
Mammalian Target Of Rapamycin ◽  
Lung Parenchyma ◽  
Extracellular Signals ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Idiopathic pulmonary fibrosis (IPF) is characterised by the progressive deposition of excessive extracellular matrix proteins within the lung parenchyma and represents the most rapidly progressive and fatal of all fibrotic conditions. Current anti-fibrotic drugs approved for the treatment of IPF fail to halt disease progression and have significant side-effect profiles. Therefore, there remains a pressing need to develop novel therapeutic strategies for IPF. Mammalian target of rapamycin (mTOR) forms the catalytic subunit of two complexes, mTORC1 and mTORC2. mTORC1 acts as critical cellular sensor which integrates intracellular and extracellular signals to reciprocally regulate a variety of anabolic and catabolic processes. The emerging evidence for a critical role for mTORC1 in influencing extracellular matrix production, metabolism, autophagy and senescence in the setting of IPF highlights this axis as a novel therapeutic target with the potential to impact multiple IPF pathomechanisms.

scholarly journals Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target

2019 ◽  
Vol 19 (1) ◽  
pp. 187-198 ◽  
Author(s):  
Toshihiro Kushibiki ◽  
Toru Nakamura ◽  
Masumi Tsuda ◽  
Takahiro Tsuchikawa ◽  
Koji Hontani ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Therapeutic Target ◽  
Novel Therapeutic

scholarly journals The Role of DLLs in Cancer: A Novel Therapeutic Target

2020 ◽  
Vol Volume 13 ◽  
pp. 3881-3901 ◽  
Author(s):  
Meng-Xi Xiu ◽  
Yuan-Meng Liu ◽  
Bo-hai Kuang
Keyword(s):  
Therapeutic Target ◽  
Novel Therapeutic

Update on the role of autophagy in systemic lupus erythematosus: A novel therapeutic target

2015 ◽  
Vol 71 ◽  
pp. 190-193 ◽  
Author(s):  
Qingjun Pan ◽  
Caina Gao ◽  
Yanwen Chen ◽  
Yongmin Feng ◽  
Wei Jing Liu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Therapeutic Target ◽  
Systemic Lupus ◽  
Novel Therapeutic
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