scholarly journals Long-term in vivo degradation behavior and near-implant distribution of resorbed elements for magnesium alloys WZ21 and ZX50

2016 ◽  
Vol 42 ◽  
pp. 440-450 ◽  
Author(s):  
F. Amerstorfer ◽  
S.F. Fischerauer ◽  
L. Fischer ◽  
J. Eichler ◽  
J. Draxler ◽  
...  
Keyword(s):  
Magnesium Alloys ◽  
Degradation Behavior ◽  
In Vivo Degradation

In vivo degradation of binary magnesium alloys – a long-term study

2016 ◽  
Vol 17 (3-4) ◽  
Author(s):  
Anastasia Myrissa ◽  
Elisabeth Martinelli ◽  
Gábor Szakács ◽  
Leopold Berger ◽  
Johannes Eichler ◽  
...  
Keyword(s):  
Magnesium Alloys ◽  
Degradation Behavior ◽  
Sprague Dawley ◽  
Term Study ◽  
Bone Implant ◽  
Long Term Study ◽  
Interface Mechanics ◽  
In Vivo Degradation

AbstractBioresorbable magnesium materials are widely investigated because of their promising properties as orthopedic devices. Pure magnesium (99.99%) and two binary magnesium alloys (Mg2Ag and Mg10Gd) were used to investigate the degradation behavior, the bone adherence and bone-implant interface mechanics of these materials in growing Sprague-Dawley

Does artificial aging correctly predict the long-term in-vivo degradation behavior in zirconia hip prostheses?

2020 ◽  
Vol 31 (2) ◽  
pp. 107-117
Author(s):  
Toshiyuki Tateiwa ◽  
Yasuhito Takahashi ◽  
Giuseppe Pezzotti ◽  
Takaaki Shishido ◽  
Toshinori Masaoka ◽  
...  
Keyword(s):  
Artificial Aging ◽  
Degradation Behavior ◽  
Hip Prostheses ◽  
In Vivo Degradation

In vitro and in vivo degradation behavior and the long-term performance of biodegradable PLCL balloon implants

2020 ◽  
Vol 574 ◽  
pp. 118870 ◽  
Author(s):  
Moran Haim Zada ◽  
Awanish Kumar ◽  
Omar Elmalak ◽  
Elana Markovitz ◽  
Ruthy Icekson ◽  
...  
Keyword(s):  
Degradation Behavior ◽  
Long Term Performance ◽  
Term Performance ◽  
In Vivo Degradation

scholarly journals In-Vivo Degradation Behavior and Osseointegration of 3D Powder-Printed Calcium Magnesium Phosphate Cement Scaffolds

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 946
Author(s):  
Katharina Kowalewicz ◽  
Elke Vorndran ◽  
Franziska Feichtner ◽  
Anja-Christina Waselau ◽  
Manuel Brueckner ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Bone Substitutes ◽  
Magnesium Phosphate ◽  
Degradation Behavior ◽  
Micro Computed Tomography ◽  
Calcium Magnesium ◽  
Interest In Research ◽  
In Vivo Degradation ◽  
Volume Decrease

Calcium magnesium phosphate cements (CMPCs) are promising bone substitutes and experience great interest in research. Therefore, in-vivo degradation behavior, osseointegration and biocompatibility of three-dimensional (3D) powder-printed CMPC scaffolds were investigated in the present study. The materials Mg225 (Ca0.75Mg2.25(PO4)2) and Mg225d (Mg225 treated with diammonium hydrogen phosphate (DAHP)) were implanted as cylindrical scaffolds (h = 5 mm, Ø = 3.8 mm) in both lateral femoral condyles in rabbits and compared with tricalcium phosphate (TCP). Treatment with DAHP results in the precipitation of struvite, thus reducing pore size and overall porosity and increasing pressure stability. Over 6 weeks, the scaffolds were evaluated clinically, radiologically, with Micro-Computed Tomography (µCT) and histological examinations. All scaffolds showed excellent biocompatibility. X-ray and in-vivo µCT examinations showed a volume decrease and increasing osseointegration over time. Structure loss and volume decrease were most evident in Mg225. Histologically, all scaffolds degraded centripetally and were completely traversed by new bone, in which the remaining scaffold material was embedded. While after 6 weeks, Mg225d and TCP were still visible as a network, only individual particles of Mg225 were present. Based on these results, Mg225 and Mg225d appear to be promising bone substitutes for various loading situations that should be investigated further.

In vivo degradation behavior of Ca-deficient hydroxyapatite coated Mg–Zn–Ca alloy for bone implant application

2011 ◽  
Vol 88 (1) ◽  
pp. 254-259 ◽  
Author(s):  
Huanxin Wang ◽  
Shaokang Guan ◽  
Yisheng Wang ◽  
Hongjian Liu ◽  
Haitao Wang ◽  
...  
Keyword(s):  
Degradation Behavior ◽  
Bone Implant ◽  
In Vivo Degradation

scholarly journals Long-Term Biostability of Pet Vascular Prostheses

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Florence Dieval ◽  
Foued Khoffi ◽  
Riaz Mir ◽  
Walid Chaouch ◽  
Didier Le Nouen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Manufacturing Process ◽  
Vascular Prosthesis ◽  
Chemical Degradation ◽  
Medical Complications ◽  
Human Metabolism ◽  
Vascular Prostheses ◽  
In Vivo Degradation

PET Vascular prostheses are susceptible to physical modification and chemical degradation leading sometimes to global deterioration and rupture of the product. To understand the mechanisms of degradation, we studied 6 vascular prostheses that were explanted due to medical complications. We characterized their level of degradation by comparing them with a virgin prosthesis and carried out physicochemical and mechanical analyses. Results showed an important reduction of the fabric’s mechanical properties in specific areas. Moreover, PET taken from these areas exhibited structural anomalies and was highly degraded even in virgin prostheses. These results suggest that vascular prostheses have weak areas prior to implantation and that these areas are much more prone to in vivo degradation by human metabolism. Manufacturing process could be responsible for these weaknesses as well as designing of the compound. Therefore, we suggest that a more controlled manufacturing process could lead to a vascular prosthesis with enhanced lifespan.

In Vivo Degradation Behavior of Photo-Cross-Linkedstar-Poly(ε-caprolactone-co-d,l-lactide) Elastomers

2006 ◽  
Vol 7 (1) ◽  
pp. 365-372 ◽  
Author(s):  
Brian G. Amsden ◽  
M. Yat Tse ◽  
Norma D. Turner ◽  
Darryl K. Knight ◽  
Stephen C. Pang
Keyword(s):  
Degradation Behavior ◽  
In Vivo Degradation

Comparison between three in vitro methods to measure magnesium degradation and their suitability for predicting in vivo degradation

2018 ◽  
Vol 41 (11) ◽  
pp. 772-778 ◽  
Author(s):  
Sara R Knigge ◽  
Birgit Glasmacher
Keyword(s):  
Continuous Flow ◽  
Initial Phase ◽  
Ph Value ◽  
Degradation Products ◽  
Static Condition ◽  
Degradation Behavior ◽  
Implant Material ◽  
Static Conditions ◽  
In Vivo Degradation

A lot of research has been done in the field of magnesium-based implant material. This study is focused on finding an explanation for the large disparity in results from similar experiments in literature. The hypothesis is that many different measurement protocols are used to quantify magnesium degradation and this leads to inconsistent results. Cylindrical, pure magnesium samples were used for this study. The degradation took place in revised simulated body fluid at 37°C. Hydrogen evolution was measured to quantify the degradation. Two commonly used experimental protocols were examined: static conditions and a fluid changing method. For static testing, the samples stayed in fluid. For the fluid changing method, the fluid was changed after 2 and 5 days of immersion. In addition, a new method with continuous fluid flow was established. After an initial phase, the results confirm that for all three methods, the degradation behavior differs strongly. The static condition results in a very slow degradation rate. The fluid change method leads to a similar behavior like the static condition except that the degradation was speeded up after the fluid changes. The continuous degradation is linear for a long period after the initial phase. In comparison with in vivo degradation behavior, the degradation process in continuous flow shows the best fitting. The accumulation of degradation products, especially the increasing pH value, has a strong inhibiting effect. This cannot be observed in vivo so that a constant experimental environment realizable by continuous flow is more suitable for magnesium-based implant material testing.

In vivo degradation behavior of PDC multiblock copolymers containing poly(para-dioxanone) hard segments and crystallizable poly(epsilon-caprolactone) switching segments

2009 ◽  
Vol 1190 ◽  
Author(s):  
Bernhard Hiebl ◽  
Karl Kratz ◽  
Rosemarie Fuhrmann ◽  
Friedrich Jung ◽  
Andres Lendlein ◽  
...  
Keyword(s):  
Enzymatic Degradation ◽  
Degradation Products ◽  
In Vivo Studies ◽  
Multiblock Copolymers ◽  
Degradation Behavior ◽  
Hard Segments ◽  
In Vivo Degradation ◽  
Good Agreement

AbstractThe degradation behavior of biodegradable multiblock copolymers (PDC) containing poly(p-dioxanone) hard segments (PPDO) and crystallizable poly(epsilon-caprolactone) switching segments (PCL) synthesized via co-condensation of two oligomeric macrodiols with an aliphatic diisocyanate as junction unit was explored in in vivo and in vitro experiments. The in vitro experiments for enzymatic degradation resulted that the poly(epsilon-caprolactone) segments are degraded faster, than the poly(p-dioxanone) segments. During degradation the outer layer of the test specimen becomes porous. Finally non-soluble degradation products in form of particles were found at the surface. This observation is in good agreement with the in vivo studies, where the non-soluble degradation products in the periimplantary tissues showed a diameter of 1 – 3 micron.

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