5-Fluorouracil–lipid conjugate: Potential candidate for drug delivery through encapsulation in hydrophobic polyester-based nanoparticles

2014 ◽  
Vol 10 (11) ◽  
pp. 4685-4694 ◽  
Author(s):  
N. Ashwanikumar ◽  
Nisha Asok Kumar ◽  
S. Asha Nair ◽  
G.S. Vinod Kumar
Keyword(s):  
Drug Delivery ◽  
Potential Candidate ◽  
Lipid Conjugate

Application of quantum dots in drug delivery

2021 ◽  
Vol 11 ◽  
Author(s):  
Subham Jain N ◽  
Preeti S ◽  
Amit B Patil
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Organic Dyes ◽  
Quantum Confinement Effect ◽  
Semiconductor Nanocrystals ◽  
Drug Carriers ◽  
Research Field ◽  
The Body ◽  
Future Application ◽  
Potential Candidate

Background: The nanotechnology which has vast growth in the research field and the outcome product of nanotechnology is nanoparticles. Quantum dots with a size range of 2-10nm represents a new form in nanotechnology materials. It has showed widespread attention in recent years in the field of science and its application in drug delivery. Quantum dots are semiconductor nanocrystals which possess interesting properties and characteristics such as unique optical properties, quantum confinement effect and emit fluorescence on excitation with a light source which makes them a potential candidate for nano-probes and for carriers for biological application. Objective: The objective of the article is to explain the role and application of Quantum dots in drug delivery and its future application in pharmaceutical science and research. This review focuses on drug delivery through Quantum dots and Quantum dots helping nanocarriers for drug delivery. The development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research. The Quantum Dot labelled nano-carrier can able to deliver the drugs with fewer side effects and it can able to trace the drug location in the body. Results: The Fluorescent emission of Quantum dots is better than other organic dyes which leads to better drug delivery for cancer or acting as a tag for other drug carriers. Conclusion: Because of emission property of Quantum Dots, it can be said used with other drug carriers and later it can be traced with the help of Quantum Dots. Quantum dots can be said as smart Drug delivery.

Injectable camptothecin conjugated hydrogels with simultaneous drug release and degradation

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 94661-94668 ◽  
Author(s):  
Lilong Gao ◽  
Yadong Chen ◽  
Qiaojie Luo ◽  
Ying Wang ◽  
Xiaodong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Hepg2 Cells ◽  
Potential Candidate ◽  
Degradation Properties

Novel injectable camptothecin conjugated hydrogels with simultaneous drug release and degradation properties were prepared, which show significant cytotoxicity to HepG2 cells, and could be a potential candidate for intratumor drug delivery.

Surfactant-free polymeric nanoparticles composed of PEG, cholic acid and a sucrose moiety

2014 ◽  
Vol 2 (25) ◽  
pp. 3946-3955 ◽  
Author(s):  
Carina I. C. Crucho ◽  
M. Teresa Barros
Keyword(s):  
Drug Delivery ◽  
Cholic Acid ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Building Blocks ◽  
Amphiphilic Polymers ◽  
Potential Candidate ◽  
Nanoprecipitation Method ◽  
Drug Delivery Applications

New amphiphilic polymers synthesized from a sucrose-containing conjugate exhibited interesting self-assembly properties in water. Owing to their amphiphilic characteristics polymeric nanoparticles were prepared by a nanoprecipitation method without any surfactants. These nanoparticles formulated with biocompatible building blocks can be considered a potential candidate for drug delivery applications.

Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines

RSC Advances ◽  
2016 ◽  
Vol 6 (103) ◽  
pp. 101688-101696 ◽  
Author(s):  
Tarek Baati ◽  
Bochra Bejaoui Kefi ◽  
Aicha Aouane ◽  
Leila Njim ◽  
Florence Chaspoul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cellular Uptake ◽  
Direct Consequence ◽  
Titanate Nanotubes ◽  
Loading Capacity ◽  
Potential Candidate ◽  
Surface Change ◽  
Tubular Shape

Titanate nanotubes (Ti-Nts) have proved to be a potential candidate for drug delivery due to their large surface change and higher cellular uptake as a direct consequence of their tubular shape.

scholarly journals Perspective Insights to Bio-Nanomaterials for the Treatment of Neurological Disorders

2021 ◽  
Vol 9 ◽  
Author(s):  
Johra Khan ◽  
Mithun Rudrapal ◽  
Eijaz Ahmed Bhat ◽  
Ahmad Ali ◽  
Mohammad Alaidarous ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurological Disorders ◽  
Potential Candidate ◽  
Biomedical Sciences ◽  
Self Assembling ◽  
Cord Injury ◽  
Promising Area ◽  
The Central Nervous System ◽  
Neurological Conditions ◽  
Regenerative Therapies

The significance of biomaterials is well appreciated in nanotechnology, and its use has resulted in major advances in biomedical sciences. Although, currently, very little data is available on the clinical trial studies for treatment of neurological conditions, numerous promising advancements have been reported in drug delivery and regenerative therapies which can be applied in clinical practice. Among the commonly reported biomaterials in literature, the self-assembling peptides and hydrogels have been recognized as the most potential candidate for treatment of common neurological conditions such as Alzheimer’s, Parkinson’s, spinal cord injury, stroke and tumors. The hydrogels, specifically, offer advantages like flexibility and porosity, and mimics the properties of the extracellular matrix of the central nervous system. These factors make them an ideal scaffold for drug delivery through the blood-brain barrier and tissue regeneration (using stem cells). Thus, the use of biomaterials as suitable matrix for therapeutic purposes has emerged as a promising area of neurosciences. In this review, we describe the application of biomaterials, and the current advances, in treatment of statistically common neurological disorders.

scholarly journals Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1662
Author(s):  
Mahadevamurthy Murali ◽  
Nataraj Kalegowda ◽  
Hittanahallikoppal G. Gowtham ◽  
Mohammad Azam Ansari ◽  
Mohammad N. Alomary ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Food Packaging ◽  
Biological Activities ◽  
Drug Loading ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Potential Candidate

Zinc oxide nanoparticles have become one of the most popular metal oxide nanoparticles and recently emerged as a promising potential candidate in the fields of optical, electrical, food packaging, and biomedical applications due to their biocompatibility, low toxicity, and low cost. They have a role in cell apoptosis, as they trigger excessive reactive oxygen species (ROS) formation and release zinc ions (Zn2+) that induce cell death. The zinc oxide nanoparticles synthesized using the plant extracts appear to be simple, safer, sustainable, and more environmentally friendly compared to the physical and chemical routes. These biosynthesized nanoparticles possess strong biological activities and are in use for various biological applications in several industries. Initially, the present review discusses the synthesis and recent advances of zinc oxide nanoparticles from plant sources (such as leaves, stems, bark, roots, rhizomes, fruits, flowers, and seeds) and their biomedical applications (such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, photocatalytic, wound healing, and drug delivery), followed by their mechanisms of action involved in detail. This review also covers the drug delivery application of plant-mediated zinc oxide nanoparticles, focusing on the drug-loading mechanism, stimuli-responsive controlled release, and therapeutic effect. Finally, the future direction of these synthesized zinc oxide nanoparticles’ research and applications are discussed.

scholarly journals Formulation and Evaluation of Floating Matrix Tablets of Sacubitril and Valsartan

2019 ◽  
Vol 9 (4-s) ◽  
pp. 298-309
Author(s):  
Sudhakar Pathak ◽  
Harish Pandey ◽  
Sunil Kumar Shah
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Lag Time ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Potential Candidate ◽  
In Vitro Drug Release ◽  
Gastric Emptying Rate ◽  
Floating Tablets

Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The purpose of this research was to develop and evaluated floating matrix tablets of sacubitril and valsartan. The floating matrix tablets of sacubitril and valsartan were prepared by direct compression method using altered concentrations of HPMC K4M, HPMC K100M, sodium alginate as polymers and sodium bicarbonate, citric acid as gas generating agent. FTIR, DSC studies conformed that there was no incompatibility between the polymers and the drug. Tablet preformulation parameters were within the pharmacopoeias limit. Tablets were evaluated by different parameters such as weight uniformity, content uniformity, thickness, hardness, in vitro release studies, buoyancy determination and kinetic analysis of dissolution data. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. Tablet showed ≤ 1min lag time, continuance of buoyancy for >12 h. The in-vitro drug release pattern of sacubitril and valsartan optimized floating tablets (F16) was fitted to different kinetic models which showed highest regression (r2 = 0.9838) for Higuchi model. The Optimized formulation (F16) showed no significant change in physical appearance, drug content, floating lag time, in vitro dissolution studies after 75%±5% RH at 40±20C relative humidity for 6 months.  Prepared floating tablets of sacubitril and valsartan may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.  

scholarly journals Biological Evaluation of Naproxen–Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 122 ◽  
Author(s):  
Rute Moreira ◽  
Peter J. Jervis ◽  
André Carvalho ◽  
Paula M. T. Ferreira ◽  
José A. Martins ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Biological Evaluation ◽  
Mri Contrast Agents ◽  
Dual Function ◽  
Potential Candidate ◽  
Cox Inhibitors ◽  
Cox 2 ◽  
Drug Delivery Applications ◽  
Anti Inflammatory

The use of peptide–drug conjugates is emerging as a powerful strategy for targeted drug delivery. Previously, we have found that peptides conjugated to a non-steroidal anti-inflammatory drug (NSAID), more specifically naproxen–dehydrodipeptide conjugates, readily form nanostructured fibrilar supramolecular hydrogels. These hydrogels were revealed as efficacious nano-carriers for drug delivery applications. Moreover, the incorporation of superparamagnetic iron oxide nanoparticles (SPIONs) rendered the hydrogels responsive to external magnetic fields, undergoing gel-to-solution phase transition upon remote magnetic excitation. Thus, magnetic dehydrodipeptide-based hydrogels may find interesting applications as responsive Magnetic Resonance Imaging (MRI) contrast agents and for magnetic hyperthermia-triggered drug-release applications. Supramolecular hydrogels where the hydrogelator molecule is endowed with intrinsic pharmacological properties can potentially fulfill a dual function in drug delivery systems as (passive) nanocariers for incorporated drugs and as active drugs themselves. In this present study, we investigated the pharmacological activities of a panel of naproxen–dehydrodipeptide conjugates, previously studied for their hydrogelation ability and as nanocarriers for drug-delivery applications. A focused library of dehydrodipeptides, containing N-terminal canonical amino acids (Phe, Tyr, Trp, Ala, Asp, Lys, Met) N-capped with naproxen and linked to a C-terminal dehydroaminoacid (ΔPhe, ΔAbu), were evaluated for their anti-inflammatory and anti-cancer activities, as well as for their cytotoxicity to non-cancer cells, using a variety of enzymatic and cellular assays. All compounds except one were able to significantly inhibit lipoxygenase (LOX) enzyme at a similar level to naproxen. One of the compounds 4 was able to inhibit the cyclooxygenase-2 (COX-2) to a greater extent than naproxen, without inhibiting cyclooxygenase-1 (COX-1), and therefore is a potential lead in the search for selective COX-2 inhibitors. This hydrogelator is a potential candidate for dual COX/LOX inhibition as an optimised strategy for treating inflammatory conditions.

Synthesis of a phenylboronic ester-linked PEG-lipid conjugate for ROS-responsive drug delivery

2017 ◽  
Vol 8 (40) ◽  
pp. 6209-6216 ◽  
Author(s):  
Tianhui Zhang ◽  
Xin Chen ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
Xuesi Chen
Keyword(s):  
Drug Delivery ◽  
Lipid Conjugate

A kind of phenylboronic ester-linked PEG-lipid conjugate was designed and synthesized for ROS-responsive drug delivery.

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