Surfactant-free polymeric nanoparticles composed of PEG, cholic acid and a sucrose moiety

2014 ◽  
Vol 2 (25) ◽  
pp. 3946-3955 ◽  
Author(s):  
Carina I. C. Crucho ◽  
M. Teresa Barros
Keyword(s):  
Drug Delivery ◽  
Cholic Acid ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Building Blocks ◽  
Amphiphilic Polymers ◽  
Potential Candidate ◽  
Nanoprecipitation Method ◽  
Drug Delivery Applications

New amphiphilic polymers synthesized from a sucrose-containing conjugate exhibited interesting self-assembly properties in water. Owing to their amphiphilic characteristics polymeric nanoparticles were prepared by a nanoprecipitation method without any surfactants. These nanoparticles formulated with biocompatible building blocks can be considered a potential candidate for drug delivery applications.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

scholarly journals Self-assembly of the monohydroxy triterpenoid lupeol yielding nano-fibers, sheets and gel: environmental and drug delivery applications

RSC Advances ◽  
2021 ◽  
Vol 11 (53) ◽  
pp. 33500-33510
Author(s):  
Saikat Kumar Panja ◽  
Soumen Patra ◽  
Braja Gopal Bag
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Organic Liquids ◽  
Supramolecular Gels ◽  
Drug Delivery Applications

The monohydroxy triterpenoid lupeol forms gels in organic and aqueous organic liquids via self-assembly. The resulting supramolecular gels could be utilized for pollutant capture, drug entrapment and release applications.

Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Sara Yazdani ◽  
Seyed Mohammad Ghoreishi ◽  
Neda Habibi
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Amino Acid Sequences ◽  
Molecular Structures ◽  
Flufenamic Acid ◽  
Mixture Ratio ◽  
Drug Molecules ◽  
Release Capacity ◽  
Essential Properties ◽  
Drug Delivery Applications

Background: Due to their solid-like porous structure, molecular organogel and microcrystal structures have the capabilities of loading drug molecules, encapsulation, and extended release, all considered as essential properties in drug delivery applications. Phases of these structures, however, depend on the solvent used during the gelation process. Objective: Understanding the phase transition between organogel and microcrystal structures through adjusting the mixture ratio of different co-solvents. Method: Short peptide Diphenylalanine as the gelation building block was used due to its amino acid sequences that can be exactly selected at its molecular levels. Ethanol as a polar solvent was used in combination with four other co-solvents with different polarity levels, namely Xylene, Toluene, Acetone, and Dimethyl Sulfoxide. The morphology of molecular structures of each co-solvent combination at each ratio level was examined as well as the loading and release properties for a non-polar Flufenamic Acid drug. Results: The resultant structure wasaffected by the polarity of the co-solvents; in particular, in the sample containing 25 μg/ml of the drug, 94% of the drug amount was loaded inside the organogel. By increasing the drug concentration to 50, 75, and 100 μg/ml, the loading capability decreased to 76%, 47%, and 33%, respectively. Conclusion: Molecular organogels have excellent capabilities of loading drug molecules, while microcrystal structures have higher release capacity. The findings of this study reveal how to best design a gelation method to obtain maximum loading or release properties for a particular peptide-based drug delivery application.

Microfluidic self-assembly of polymeric nanoparticles with tunable compactness for controlled drug delivery

Polymer ◽  
2013 ◽  
Vol 54 (18) ◽  
pp. 4972-4979 ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Hamid Mirzadeh ◽  
Faramarz Afshar Taromi ◽  
Bo Nyström
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Controlled Drug Delivery

scholarly journals Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31777-31782 ◽  
Author(s):  
Rashmi Rashmi ◽  
Abhishek K. Singh ◽  
Katharina Achazi ◽  
Boris Schade ◽  
Christoph Böttcher ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Transport Behaviour ◽  
Drug Delivery Applications

Non-ionic bolaamphiphiles as nanocarrier for biomedical applications.

Small-Molecule Probe for Sensing Serum Albumin with Consequential Self-Assembly as a Fluorescent Organic Nanoparticle for Bioimaging and Drug-Delivery Applications

2020 ◽  
Vol 3 (5) ◽  
pp. 3099-3113 ◽  
Author(s):  
Subhajit Guria ◽  
Avijit Ghosh ◽  
Priyanka Upadhyay ◽  
Manas kumar Das ◽  
Tanushree Mishra ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Serum Albumin ◽  
Small Molecule ◽  
Self Assembly ◽  
Drug Delivery Applications ◽  
Small Molecule Probe

A modular approach towards drug delivery vehicles using oxanorbornane-based non-ionic amphiphiles

2016 ◽  
Vol 4 (48) ◽  
pp. 8025-8032 ◽  
Author(s):  
D. Sirisha Janni ◽  
U. Chandrasekhar Reddy ◽  
Soumya Saroj ◽  
K. M. Muraleedharan
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Self Assembly ◽  
The Self ◽  
Head Group ◽  
Modular Approach ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Drug Delivery Applications ◽  
Supramolecular Aggregates

The self-assembly of non-ionic amphiphiles with hydroxylated oxanorbornane head-group was controlled using amino acid units as spacers between hydrophilic and lipophilic domains to get spherical supramolecular aggregates suitable for drug delivery applications.

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