Surface-enhanced Raman spectroscopy combined with atomic force microscopy for ultrasensitive detection of thrombin

2009 ◽  
Vol 393 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Anna Rita Bizzarri ◽  
Salvatore Cannistraro
Keyword(s):  
Raman Spectroscopy ◽  
Atomic Force Microscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Ultrasensitive Detection ◽  
Force Microscopy ◽  
Atomic Force ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Fabrication of Bioprobe Self-Assembled on Au–Te Nanoworm Structure for SERS Biosensor

Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3234
Author(s):  
Soo Min Kim ◽  
Taek Lee ◽  
Yeong-Gyu Gil ◽  
Ga Hyeon Kim ◽  
Chulhwan Park ◽  
...  
Keyword(s):  
Surface Enhanced Raman Spectroscopy ◽  
Galvanic Replacement ◽  
Ambient Conditions ◽  
Force Microscopy ◽  
Atomic Force ◽  
Surface Enhanced ◽  
Immunodeficiency Virus ◽  
Surface Enhanced Raman ◽  
Immobilized Substrate ◽  
Interconnected Structure

In the present study, we propose a novel biosensor platform using a gold-tellurium (Au–Te) nanoworm structure through surface-enhanced Raman spectroscopy (SERS). Au–Tenanoworm was synthesized by spontaneous galvanic replacement of sacrificial Te nanorods templated with Au (III) cations under ambient conditions. The fabricated Au–Te nanoworm exhibited an interconnected structure of small spherical nanoparticles and was found to be effective at enhancing Raman scattering. The Au–Te nanoworm-immobilized substrate exhibited the ability to detect thyroxine using an aptamer-tagged DNA three-way junction (3WJ) and glycoprotein 120 (GP120) human immunodeficiency virus (HIV) using an antibody. The modified substrates were investigated by scanning electron microscopy and atomic force microscopy (AFM). The optimal Au–Te nanoworm concentration and immobilization time for the thyroxine biosensor platform were further determined by SERS experimentation. Thus, the present study showed that the Au–Te nanoworm structure could be applied to various biosensor platforms.

Ultrasensitive detection of phenolic antioxidants by surface enhanced Raman spectroscopy

2017 ◽  
Author(s):  
Nancy Ornelas-Soto ◽  
Iris A. Aguilar-Hernández ◽  
Nils Kristian Afseth ◽  
Tzarara López-Luke ◽  
Flavio Contreras-Torres ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Phenolic Antioxidants ◽  
Ultrasensitive Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications

2017 ◽  
Author(s):  
Anil K. Kodali ◽  
Rohit Bhargava
Keyword(s):  
Raman Spectroscopy ◽  
Biomedical Applications ◽  
Spectroscopic Imaging ◽  
Surface Enhanced Raman Spectroscopy ◽  
Ultrasensitive Detection ◽  
Optical Resonances ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman ◽  
Ir And Raman

This article describes the use of nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications. Engineered probes and surfaces are promising tools for enhancing signals for ultrasensitive detection of diseases like carcinoma. Two methods of interest are surface-enhanced infrared absorption (SEIRA) spectroscopy and surface-enhanced Raman spectroscopy (SERS) for IR and Raman modalities, respectively. SERS and SEIRA can be broadly categorized under a common modality termed surface-enhanced vibrational spectroscopy. This article first reviews various breakthrough findings reported in SERS and SEIRA, along with different types ofsubstrates and contrast agents used in realizing the enhancement and theories proposed to explain these findings. It then considers the configurations of nano-LAMPs and presents example results demonstrating their optical resonances and tunability. Finally, it evaluates a few techniques for fabricating multilayered nanoparticles and highlights some issues with respect to fabrication.

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