Atomic force microscopy and surface‐enhanced Raman spectroscopy. I. Ag island films and Ag film over polymer nanosphere surfaces supported on glass

1993 ◽  
Vol 99 (3) ◽  
pp. 2101-2115 ◽  
Author(s):  
R. P. Van Duyne ◽  
J. C. Hulteen ◽  
D. A. Treichel
Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3234
Author(s):  
Soo Min Kim ◽  
Taek Lee ◽  
Yeong-Gyu Gil ◽  
Ga Hyeon Kim ◽  
Chulhwan Park ◽  
...  

In the present study, we propose a novel biosensor platform using a gold-tellurium (Au–Te) nanoworm structure through surface-enhanced Raman spectroscopy (SERS). Au–Tenanoworm was synthesized by spontaneous galvanic replacement of sacrificial Te nanorods templated with Au (III) cations under ambient conditions. The fabricated Au–Te nanoworm exhibited an interconnected structure of small spherical nanoparticles and was found to be effective at enhancing Raman scattering. The Au–Te nanoworm-immobilized substrate exhibited the ability to detect thyroxine using an aptamer-tagged DNA three-way junction (3WJ) and glycoprotein 120 (GP120) human immunodeficiency virus (HIV) using an antibody. The modified substrates were investigated by scanning electron microscopy and atomic force microscopy (AFM). The optimal Au–Te nanoworm concentration and immobilization time for the thyroxine biosensor platform were further determined by SERS experimentation. Thus, the present study showed that the Au–Te nanoworm structure could be applied to various biosensor platforms.


Plasmonics ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. 1279-1284 ◽  
Author(s):  
Fang Liu ◽  
Yonghua Lu ◽  
Wenhai Yu ◽  
Qiang Fu ◽  
Pei Wang ◽  
...  

1993 ◽  
Vol 47 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Joel C. Rubim ◽  
Jae-Ho Kim ◽  
Eric Henderson ◽  
Therese M. Cotton

Three different methods were used to roughen brass (Cu/Zn = 67/33) electrodes in 0.5 M H2SO4 containing 1.0 mM benzotriazole (BTAH): (1) polarization at +0.05 V vs. saturated calomel for 5 min; (2) immersion in the above solution for six hours; and (3) oxidation-reduction cycling in the presence of chloride ion. The surfaces prepared by the first two methods exhibited surface-enhanced Raman scattering (SERS) spectra of the polymeric complex [Cu(I)BTA] n. The SERS spectrum obtained from electrodes prepared by the third method is very similar to that of [CU(I)C1BTAH]4. Examination of the electrodes by atomic force microscopy (AFM) showed that a large number of grain boundary sites are formed by the roughening processes. This effect is attributed to the loss of zinc, which occurs during corrosion of the mirror-like, polished brass electrode surface in the sulfuric acid solution.


2010 ◽  
Vol 24 (1-2) ◽  
pp. 113-117 ◽  
Author(s):  
Claire S. Sweetenham ◽  
Ioan Notingher

We have developed a Raman microspectroscopy system optimised for studying supported lipid bilayers (SLB). This system combines the benefits of Raman spectroscopy with the high spatial resolution of confocal microscopy. Furthermore, the additional incorporation of an atomic force microscope (AFM) makes it possible to directly correlate chemical information with spatial features of samples at the nanoscale. We focus on the limits of this system for detecting a single SLB and imaging its microdomains, and employ surface-enhanced Raman spectroscopy (SERS) to improve the sensitivity achieved with Raman microspectroscopy.


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