Apoptosis in the hydropic cochlea of guinea pigs following immune reaction of the endolymphatic sac: immunohistochemical analysis

2001 ◽  
Vol 258 (6) ◽  
pp. 296-299 ◽  
Author(s):  
K. Watanabe ◽  
S. Tomiyama ◽  
K. Jinnouchi ◽  
T. Yagi
Keyword(s):  
Guinea Pigs ◽  
Immune Reaction ◽  
Immunohistochemical Analysis ◽  
Endolymphatic Sac

Fluctuating Hearing Loss following Immune Reaction in the Endolymphatic Sac of Guinea Pigs

ORL ◽  
1995 ◽  
Vol 57 (3) ◽  
pp. 122-128 ◽  
Author(s):  
Shunichi Tomiyama ◽  
Toshiyuki Kinoshita ◽  
Ken Jinnouchi ◽  
Tetsuo Ikezono ◽  
Yuichi Gotoh ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pigs ◽  
Immune Reaction ◽  
Endolymphatic Sac ◽  
Fluctuating Hearing Loss

Potassium level in endolymphatic sac of guinea pigs in vivo

1979 ◽  
Vol 222 (1) ◽  
pp. 77-78 ◽  
Author(s):  
H. Miyamoto ◽  
C. Morgenstern
Keyword(s):  
Guinea Pigs ◽  
Potassium Level ◽  
Endolymphatic Sac

scholarly journals Pichinde Virus Infection of Outbred Hartley Guinea Pigs as a Surrogate Animal Model for Human Lassa Fever: Histopathological and Immunohistochemical Analyses

Pathogens ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 579 ◽  
Author(s):  
Wun-Ju Shieh ◽  
Shuiyun Lan ◽  
Sherif R. Zaki ◽  
Hinh Ly ◽  
Yuying Liang
Keyword(s):  
Animal Model ◽  
Surrogate Model ◽  
Guinea Pigs ◽  
Virulent Strain ◽  
Small Animal ◽  
Immunohistochemical Analysis ◽  
Lassa Fever ◽  
Lassa Virus ◽  
Pichinde Virus ◽  
Guinea Pig Model

Lassa virus (LASV) is a mammarenavirus (arenavirus) that causes zoonotic infection in humans that can lead to fatal hemorrhagic Lassa fever (LF) disease. Currently, there are no FDA-approved vaccines or therapeutics against LASV. Development of treatments against LF and other related arenavirus-induced hemorrhagic fevers (AHFs) requires relevant animal models that can recapitulate clinical and pathological features of AHF diseases in humans. Laboratory mice are generally resistant to LASV infection, and non-human primates, while being a good animal model for LF, are limited by their high cost. Here, we describe a small, affordable, and convenient animal model that is based on outbred Hartley guinea pigs infected with Pichinde virus (PICV), a mammarenavirus that is non-pathogenic in humans, for use as a surrogate model of human LF. We conducted a detailed analysis of tissue histopathology and immunohistochemical analysis of different organs of outbred Hartley guinea pigs infected with different PICV strains that show differential disease phenotypes and pathologies. Comparing to infection with the avirulent PICV strain (P2 or rP2), animals infected with the virulent strain (P18 or rP18) show extensive pathological changes in different organs that sustain high levels of virus replication. The similarity of tissue pathology and viral antigen distribution between the virulent PICV–guinea pig model and lethal human LASV infection supports a role of this small animal model as a surrogate model of studying human LF in order to understand its pathogenesis and for evaluating potential preventative and therapeutic options against AHFs.

scholarly journals Measurement of Endolymphatic Sac Blood Flow in Guinea Pigs.

1992 ◽  
Vol 51 (3) ◽  
pp. 391-395
Author(s):  
Yoshiro Yazawa ◽  
Masaaki Kitahara
Keyword(s):  
Blood Flow ◽  
Guinea Pigs ◽  
Endolymphatic Sac

Immunohistochemical analysis of the immune reaction in the nervous system in paraneoplastic encephalomyelitis

Neurology ◽  
1990 ◽  
Vol 40 (2) ◽  
pp. 219-219 ◽  
Author(s):  
F. Graus ◽  
T. Ribalta ◽  
E. Campo ◽  
R. Monforte ◽  
A. Urbano ◽  
...  
Keyword(s):  
Nervous System ◽  
Immune Reaction ◽  
Immunohistochemical Analysis
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