Immunohistochemical Analysis of the Lateral Wall of the Endolymphatic Sac in Meniere�s Patients

2015 ◽  
pp. 129-134 ◽  
Author(s):  
Takashi Futaki ◽  
Yumiko Nagao ◽  
Shigeru Kikuchi
Keyword(s):  
Immunohistochemical Analysis ◽  
Lateral Wall ◽  
Endolymphatic Sac

scholarly journals Immunohistochemical analysis of the lateral wall of the endolymphatic sac of Ménière's patients

1987 ◽  
Vol 46 (Suppl-2) ◽  
pp. 51-54
Author(s):  
Shigeru Kikuchi ◽  
Takashi Futaki ◽  
Yumiko Nagao
Keyword(s):  
Immunohistochemical Analysis ◽  
Lateral Wall ◽  
Endolymphatic Sac

scholarly journals IgG Deposition in the Lateral Wall of the Endolymphatic Sac in Patients with Menier's Disease

1989 ◽  
Vol 48 (5Supplement) ◽  
pp. 72-77
Author(s):  
Takashi Futaki ◽  
Mei-zin Schu ◽  
Shigeru Kikuchi ◽  
Yumiko Nagao
Keyword(s):  
Lateral Wall ◽  
Endolymphatic Sac

scholarly journals Duodenal Gastrointestinal Stromal Tumor: A Rare Disease in a Young Adult Female Patient Presenting with Life-Threatening Hemorrhage

2021 ◽  
pp. 519-524
Author(s):  
Manrica Fabbi ◽  
Laura Castoldi ◽  
Maurizio Sallusti ◽  
Giorgio Rossi ◽  
Paolo Reggiani
Keyword(s):  
Female Patient ◽  
Elective Surgery ◽  
Tumor Staging ◽  
Transarterial Embolization ◽  
Surgical Care ◽  
Immunohistochemical Analysis ◽  
Lateral Wall ◽  
High Power Field ◽  
Contrast Enhanced Ct ◽  
Life Threatening

Duodenal gastrointestinal stromal tumors (dGISTs) may be a source of life-threatening hemorrhage that leads to emergency surgical care, precluding tumor staging and the planning of an elective treatment. In this study, we report a case of potentially lethal bleeding dGIST in a young woman successfully treated by an organ-preserving elective surgery after endoscopic and angiographic hemostasis. A 26-year-old female patient was admitted to the Emergency Unit of our hospital with the complaints of hematemesis and melena in the previous 12 h. An upper endoscopy showed a 4-cm submucosal lesion, between the 2nd and 3rd part of the duodenum, in the lateral wall, with massive bleeding arising from central ulceration. Hemostasis was initially achieved endoscopically and then optimized by transarterial embolization. After a contrast-enhanced CT, the patient underwent planning elective surgery. Intraoperatively, a 3-cm lesion was confirmed and resected by excision of the full-thickness duodenum with adequate free margins. Immunohistochemical analysis of the specimen revealed to be a dGIST, with a low mitotic count (<5 mitosis/50 high power field), and tumor necrosis present in <50% of the lesion. The patient had an uneventful course.

scholarly journals Lymphoepithelioma-Like Carcinoma of the Bladder: A Case Report of a Rare and Particular Variant of Urothelial Carcinoma

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Youness Jabbour ◽  
Youssef Jabri ◽  
Hamza Lamchahab ◽  
Mohammed Tbouda ◽  
Ahmed Jahid ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
English Literature ◽  
Immunohistochemical Analysis ◽  
Lateral Wall ◽  
Large Tumor ◽  
Left Lateral Wall ◽  
Classification Of Tumors ◽  
Carcinoma Of The Bladder ◽  
Muscle Invasive

Lymphoepithelioma-like carcinoma of the bladder (LELCB) is a rare variant of urothelial carcinoma first described by Zukerberg in 1991 and confirmed as a variant of urothelial carcinoma by the WHO classification of tumors of the urinary system. LELCB is characterized by a marked infiltration of lymphocytes in the area involved by the tumor which may coexist with the conventional urothelial carcinoma. LELCB are classified according to the percentage of lymphoepithelioma component within the tumor with the prognosis depending on the percentage. We report a new case of pure LELCB occurring in 63-year-old woman presenting with hematuria. Ultrasonography and cystoscopy revealed a large tumor on the left lateral wall of the bladder. Transurethral resection of the bladder tumor (TURBT) was performed. Pathological and immunohistochemical analysis revealed a high-grade muscle-invasive LELCB (G3pT2). The patient underwent an adjuvant systemic chemotherapy with no recurrence after a ten-month follow-up. To our knowledge, this is the second Moroccan case of LELCB reported in the English literature. Although its rare occurrence prognosis and ideal therapeutic management of LELCB have not been clearly established yet, literature findings encourage the adoption of a conservative approach in treatment of LELCB.

scholarly journals Glioblastoma Proximity to the Lateral Ventricle Alters Neurogenic Cell Populations of the Subventricular Zone

2021 ◽  
Vol 11 ◽  
Author(s):  
Luisina B. Ripari ◽  
Emily S. Norton ◽  
Raquel Bodoque-Villar ◽  
Stephanie Jeanneret ◽  
Montserrat Lara-Velazquez ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Median Survival ◽  
Subventricular Zone ◽  
Immunohistochemical Analysis ◽  
Lateral Wall ◽  
Tumor Location ◽  
Rodent Model ◽  
Clinical Aspects ◽  
Cell Populations ◽  
Bidirectional Signaling

Despite current strategies combining surgery, radiation, and chemotherapy, glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults. Tumor location plays a key role in the prognosis of patients, with GBM tumors located in close proximity to the lateral ventricles (LVs) resulting in worse survival expectancy and higher incidence of distal recurrence. Though the reason for worse prognosis in these patients remains unknown, it may be due to proximity to the subventricular zone (SVZ) neurogenic niche contained within the lateral wall of the LVs. We present a novel rodent model to analyze the bidirectional signaling between GBM tumors and cells contained within the SVZ. Patient-derived GBM cells expressing GFP and luciferase were engrafted at locations proximal, intermediate, and distal to the LVs in immunosuppressed mice. Mice were either sacrificed after 4 weeks for immunohistochemical analysis of the tumor and SVZ or maintained for survival analysis. Analysis of the GFP+ tumor bulk revealed that GBM tumors proximal to the LV show increased levels of proliferation and tumor growth than LV-distal counterparts and is accompanied by decreased median survival. Conversely, numbers of innate proliferative cells, neural stem cells (NSCs), migratory cells and progenitors contained within the SVZ are decreased as a result of GBM proximity to the LV. These results indicate that our rodent model is able to accurately recapitulate several of the clinical aspects of LV-associated GBM, including increased tumor growth and decreased median survival. Additionally, we have found the neurogenic and cell division process of the SVZ in these adult mice is negatively influenced according to the presence and proximity of the tumor mass. This model will be invaluable for further investigation into the bidirectional signaling between GBM and the neurogenic cell populations of the SVZ.

Coexpression of erythropoietin and its receptor in endolymphatic sac tumors

2005 ◽  
Vol 103 (2) ◽  
pp. 284-288 ◽  
Author(s):  
Timothy W. A. Vogel ◽  
Alexander O. Vortmeyer ◽  
Irina A. Lubensky ◽  
Youn-Soo Lee ◽  
Makoto Furuta ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Endolymphatic Sac ◽  
Organ Distribution ◽  
Cell Of Origin ◽  
Endolymphatic Sac Tumor ◽  
Content Type ◽  
Gene Deficiency ◽  
Vhl Disease ◽  
Associated Tumors ◽  
Fine Print

Object. Von Hippel—Lindau (VHL) disease is characterized by multiple tumors in specific organs. The cell of origin and the reason for the particular organ distribution of the tumors remains unknown. Endolymphatic sac tumor (ELST) is one of the lesions associated with VHL disease. Data from previous studies of VHL disease—associated hemangioblastomas (HBs) and renal cell carcinomas (RCCs) have indicated that VHL gene deficiency causes coexpression of erythropoietin (Epo) and its receptor (Epo-R), which facilitates tumor growth. Methods. The authors studied ELSTs from five patients with VHL germline mutations. Analysis of the five ELST samples revealed loss of the wild-type allele, consistent with Knudson's two-hit hypothesis for tumorigenesis. All five ELST specimens were characterized microscopically and by immunohistochemical analysis. Coexpression of Epo and Epo-R was found in all five tumors on immunohistochemical studies and confirmed through reverse transcription—polymerase chain reaction and Western blot analysis. Conclusions. Expression of Epo appears to be a result of VHL gene deficiency, whereas the simultaneous coexpression of Epo-R may reflect a developmental mechanism of tumorigenesis. Coexpression of Epo and Epo-R in ELSTs together with the morphological and genetic similarities of these lesions with other VHL disease—associated tumors indicates that VHL disease—associated tumors in different organs share common pathogenetic pathways.

Are Papillary Adenomas Endolymphatic Sac Tumors?

1995 ◽  
Vol 104 (8) ◽  
pp. 613-619 ◽  
Author(s):  
Anita Pollak ◽  
Max Spycher ◽  
Andreas Böhmer ◽  
Ugo Fisch
Keyword(s):  
Temporal Bone ◽  
Lateral Wall ◽  
Jugular Bulb ◽  
Endolymphatic Sac ◽  
Middle Ear Mucosa ◽  
Von Hippel Lindau ◽  
Cystic Tumors ◽  
Resected Tumor ◽  
S 100 ◽  
Von Hippel Lindau Disease

Papillary adenomas of the temporal bone have been considered as originating from the endolymphatic sac. The radiologic, surgical, and pathologic findings in a patient suffering from von Hippel—Lindau disease with bilateral papillary adenomas of the temporal bone cast some doubt on this site of origin. Radiologically, the center of tumor growth was at the top of the jugular bulb. Intraoperatively, the tumor was found to have reached the lateral wall of the endolymphatic sac, but the lumen was tumor-free. Both ciliated and nonciliated tumor cells were found in the resected tumor, resembling the ultrastructure of normal epithelial lining in the human mastoid. A strong positive immunohistochemical reaction for keratin and negative reactions for vimentin, glial fibrillary acidic protein, and S-100 protein in the tumor tissue of this patient are typical for middle ear mucosa. Therefore, the described papillary adenoma originated from the mucosa of the pneumatic spaces surrounding the jugular bulb, and the theory that the endolymphatic sac is the origin of all papillary-cystic tumors (adenocarcinomas) should be questioned.

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