scholarly journals Measurement of Endolymphatic Sac Blood Flow in Guinea Pigs.

1992 ◽  
Vol 51 (3) ◽  
pp. 391-395
Author(s):  
Yoshiro Yazawa ◽  
Masaaki Kitahara
Keyword(s):  
Blood Flow ◽  
Guinea Pigs ◽  
Endolymphatic Sac

Fluctuating Hearing Loss following Immune Reaction in the Endolymphatic Sac of Guinea Pigs

ORL ◽  
1995 ◽  
Vol 57 (3) ◽  
pp. 122-128 ◽  
Author(s):  
Shunichi Tomiyama ◽  
Toshiyuki Kinoshita ◽  
Ken Jinnouchi ◽  
Tetsuo Ikezono ◽  
Yuichi Gotoh ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pigs ◽  
Immune Reaction ◽  
Endolymphatic Sac ◽  
Fluctuating Hearing Loss

scholarly journals Uteroplacental Blood Flow during Pregnancy in Chronically Catheterized Guinea Pigs

1982 ◽  
Vol 16 (9) ◽  
pp. 716-720 ◽  
Author(s):  
L L H Peeters ◽  
J W Sparks ◽  
G Grutters ◽  
J Girard ◽  
F C Battaglia
Keyword(s):  
Blood Flow ◽  
Guinea Pigs ◽  
Uteroplacental Blood Flow

A longitudinal study of cardiac output in unstressed pregnant guinea pigs

1985 ◽  
Vol 248 (6) ◽  
pp. R698-R701
Author(s):  
S. A. Myers ◽  
H. Y. Tseng
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Longitudinal Study ◽  
Guinea Pigs ◽  
Mammalian Species ◽  
Single Observation ◽  
Multiple Observations ◽  
Placental Blood ◽  
Significant Change ◽  
Placental Blood Flow

A previous study in pregnant guinea pigs failed to demonstrate any increase in cardiac output when a group of pregnant animals was compared with four nonpregnant animals. In the current study an increase in cardiac output of 35 +/- 14 (SE) ml/min, a 13% increase, was observed during an average 2-wk interval between 44 and 58 days of pregnancy (P less than 0.05, term 68 days, n = 8). A significant increase in placental blood flow of 14.8 +/- 6.2 ml/min (42% increase, P less than 0.05) was also observed during this interval without significant change in the percentage of cardiac output going to the uterus. The data on cardiac output and its distribution to the uteroplacental circulations are consistent with reports in other mammalian species; to accommodate the increased demands of the uteroplacental circulation, cardiac output increases as pregnancy advances. These data demonstrate that multiple observations in the same animal describe cardiac output and its distribution more accurately than a single observation.

Autoregulation of cochlear blood flow in guinea pigs

1994 ◽  
Vol 266 (2) ◽  
pp. H458-H467 ◽  
Author(s):  
J. N. Brown ◽  
A. L. Nuttall
Keyword(s):  
Blood Flow ◽  
Guinea Pigs ◽  
Venous Pressure ◽  
Vena Cava ◽  
Systemic Blood Pressure ◽  
Vascular Effects ◽  
Cochlear Blood Flow ◽  
Pharmacological Agents ◽  
Posterior Portion ◽  
Wide Range

Autoregulation of blood flow in the inner ear following uncontrolled changes in systemic blood pressure (BP), which was induced by the application of pharmacological agents that cause local and/or systemic vascular effects, has been reported in previous studies. In the current study, carotid BP was systematically manipulated without drugs, while the resulting cochlear blood flow (CBF) changes were measured using a laser Doppler flowmeter (LDF). Anesthesized guinea pigs were used, and the probe of a LDF was held against the ventral-posterior portion of the surgically exposed cochlea. A mechanical occluder was placed around the descending aorta or the inferior vena cava. BP could be elevated or lowered over a wide range and was held stable during 2-min occlusions. The mean level (+/- SD) of regulation (% delta CBF/% delta BP) for BP changes less than +/- 35% of preocclusion baseline was 0.24 +/- 0.2 (or 0.18 +/- 0.2 if BP is corrected by subtracting central venous pressure). Significant regulation occurred for BP between 20 and 70 mmHg. A demonstration of the cochlear origin of the regulatory response was obtained by “pharmacological blockade” following topical application of the vasodilator, sodium nitroprusside, to the cochlea. In this condition, CBF changed in nearly direct proportion to BP.

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