Fluctuating Hearing Loss following Immune Reaction in the Endolymphatic Sac of Guinea Pigs

ORL ◽  
1995 ◽  
Vol 57 (3) ◽  
pp. 122-128 ◽  
Author(s):  
Shunichi Tomiyama ◽  
Toshiyuki Kinoshita ◽  
Ken Jinnouchi ◽  
Tetsuo Ikezono ◽  
Yuichi Gotoh ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pigs ◽  
Immune Reaction ◽  
Endolymphatic Sac ◽  
Fluctuating Hearing Loss

Posterior petrous face meningiomas presenting with Ménière’s-like syndrome: a case series and review of the literature

2021 ◽  
pp. 1-8
Author(s):  
Ramin A. Morshed ◽  
Nicole T. Jiam ◽  
Elaina J. Wang ◽  
Stephen T. Magill ◽  
Renata M. Knoll ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Early Recognition ◽  
Preoperative Evaluation ◽  
Case Series ◽  
Tumor Location ◽  
Endolymphatic Sac ◽  
Episodic Vertigo ◽  
Cranial Nerve Viii ◽  
Fluctuating Hearing Loss

OBJECTIVE Ménière’s disease is an inner ear disorder classically characterized by fluctuating hearing loss, tinnitus, and aural fullness accompanied by episodic vertigo. While the pathogenesis of Ménière’s remains under debate, histopathological analyses implicate endolymphatic sac dysfunction with inner ear fluid homeostatic dysregulation. Little is known about whether external impingement of the endolymphatic sac by tumors may present with Ménière’s-like symptoms. The authors present a case series of 7 patients with posterior fossa meningiomas that involved the endolymphatic sac and new onset of Ménière’s-like symptoms and review the literature on this rare clinical entity. METHODS A retrospective review of patients undergoing resection of a posterior petrous meningioma was performed at the authors’ institution. Inclusion criteria were age older than 18 years; patients presenting with Ménière’s-like symptoms, including episodic vertigo, aural fullness, tinnitus, and/or hearing loss; and tumor location overlying the endolymphatic sac. RESULTS There were 7 cases of posterior petrous face meningiomas involving the vestibular aperture presenting with Ménière’s-like symptoms. Imaging and intraoperative examination confirmed no cranial nerve VIII compression or labyrinthine artery involvement accounting for audiovestibular symptoms. Of the 7 patients in the series, 6 experienced significant improvement or resolution of their vertigo, and all 7 had improvement or resolution of their tinnitus after resection. Of the 5 patients who had preoperative hearing loss, 2 experienced improvement or resolution of their ipsilateral preoperative hearing deficit, whereas the other 3 had unchanged hearing loss compared to preoperative evaluation. CONCLUSIONS Petrous face meningiomas overlying the endolymphatic sac can present with a Ménière’s syndrome. Early recognition and microsurgical excision of these tumors is critical for resolution of most symptoms and stabilization of hearing loss.

Antioxidant Enzyme Levels Inversely Covary with Hearing Loss After Amikacin Treatment

2003 ◽  
Vol 14 (03) ◽  
pp. 134-143 ◽  
Author(s):  
James J. Klemens ◽  
Robert P. Meech ◽  
Larry F. Hughes ◽  
Satu Somani ◽  
Kathleen C.M. Campbell
Keyword(s):  
Hearing Loss ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Guinea Pigs ◽  
Auditory Brainstem ◽  
Antioxidant Enzyme Activity ◽  
Control Group ◽  
Glutathione S Transferase ◽  
Brainstem Response ◽  
The Difference

This study's purpose was to determine if a correlation exists between cochlear antioxidant activity changes and auditory function after induction of aminoglycoside (AG) ototoxicity. Two groups of five 250-350 g albino guinea pigs served as subjects. For 28 days, albino guinea pigs were administered either 200 mg/kg/day amikacin, or saline subcutaneously. Auditory brainstem response testing was performed prior to the first injection and again before sacrifice, 28 days later. Cochleae were harvested and superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase activities and malondialdehyde levels were measured. All antioxidant enzymes had significantly lower activity in the amikacin group (p ≤ 0.05) than in the control group. The difference in cochlear antioxidant enzyme activity between groups inversely correlated significantly with the change in ABR thresholds. The greatest correlation was for the high frequencies, which are most affected by aminoglycosides. This study demonstrates that antioxidant enzyme activity and amikacin-induced hearing loss significantly covary.

Local application of hepatocyte growth factor using gelatin hydrogels attenuates noise-induced hearing loss in guinea pigs

2009 ◽  
Vol 129 (4) ◽  
pp. 453-457 ◽  
Author(s):  
Takatoshi Inaoka ◽  
Takayuki Nakagawa ◽  
Yayoi S. Kikkawa ◽  
Yasuhiko Tabata ◽  
Kazuya Ono ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Guinea Pigs ◽  
Local Application ◽  
Noise Induced Hearing Loss ◽  
Hepatocyte Growth

Effect over time of allopurinol on noise-induced hearing loss in guinea pigs: Efecto en el tiempo del alopurinol sobre la hipoacusia inducida por ruido en cobayos

2003 ◽  
Vol 42 (4) ◽  
pp. 227-234 ◽  
Author(s):  
Annamaria Franzé ◽  
Luigi Sequino ◽  
Claudia Saulino ◽  
Giuseppe Attanasio ◽  
Elio Marciano
Keyword(s):  
Hearing Loss ◽  
Guinea Pigs ◽  
Noise Induced Hearing Loss ◽  
Over Time

scholarly journals Sporadic Endolymphatic Sac Tumor-A Very Rare Cause of Hearing Loss, Tinnitus, and Dizziness

2017 ◽  
Vol 13 (2) ◽  
pp. 289-291 ◽  
Author(s):  
Didde Trærup Schnack ◽  
Katalin Kiss ◽  
Søren Hansen ◽  
Hidemi Miyazaki ◽  
Birgitte Bech ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Endolymphatic Sac ◽  
Endolymphatic Sac Tumor

Degeneration of auditory nerve fibers in guinea pigs with severe sensorineural hearing loss

2017 ◽  
Vol 345 ◽  
pp. 79-87 ◽  
Author(s):  
Steven Kroon ◽  
Dyan Ramekers ◽  
Emma M. Smeets ◽  
Ferry G.J. Hendriksen ◽  
Sjaak F.L. Klis ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Auditory Nerve ◽  
Guinea Pigs ◽  
Nerve Fibers ◽  
Sensorineural Hearing ◽  
Auditory Nerve Fibers

scholarly journals An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

Metabolomics ◽  
2019 ◽  
Vol 15 (10) ◽  
Author(s):  
Kristian Pirttilä ◽  
Pernilla Videhult Pierre ◽  
Jakob Haglöf ◽  
Mikael Engskog ◽  
Mikael Hedeland ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hearing Loss ◽  
Guinea Pigs ◽  
Hydrogen Gas ◽  
Untargeted Metabolomics ◽  
Metabolic Effects ◽  
Polar Component ◽  
Acquired Hearing Loss ◽  
Fit For Purpose ◽  
Tof Ms

Abstract Introduction Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H2) can alleviate the damage caused by oxidative stress and can be easily administered through inhalation. Objectives To present a protocol for untargeted metabolomics of guinea pig perilymph and investigate the effect of H2 administration on the perilymph metabolome of noise exposed guinea pigs. Methods The left ear of guinea pigs were exposed to hazardous impulse noise only (Noise, n = 10), noise and H2 (Noise + H2, n = 10), only H2 (H2, n = 4), or untreated (Control, n = 2). Scala tympani perilymph was sampled from the cochlea of both ears. The polar component of the perilymph metabolome was analyzed using a HILIC-UHPLC-Q-TOF–MS-based untargeted metabolomics protocol. Multivariate data analysis (MVDA) was performed separately for the exposed- and unexposed ear. Results MVDA allowed separation of groups Noise and Noise + H2 in both the exposed and unexposed ear and yielded 15 metabolites with differentiating relative abundances. Seven were found in both exposed and unexposed ear data and included two osmoprotectants. Eight metabolites were unique to the unexposed ear and included a number of short-chain acylcarnitines. Conclusions A HILIC-UHPLC-Q-TOF–MS-based protocol for untargeted metabolomics of perilymph is presented and shown to be fit-for-purpose. We found a clear difference in the perilymph metabolome of noise exposed guinea pigs with and without H2 treatment.

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