scholarly journals Effect of euglycaemic hyperinsulinaemia on gastric emptying and gastrointestinal hormone responses in normal subjects

Diabetologia ◽  
1998 ◽  
Vol 41 (4) ◽  
pp. 474-481 ◽  
Author(s):  
M.-F. Kong ◽  
P. King ◽  
I. A. Macdonald ◽  
P. E. Blackshaw ◽  
A. C. Perkins ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Normal Subjects ◽  
Gastrointestinal Hormone ◽  
Hormone Responses

scholarly journals The Effect of Short-Term Dietary Fructose Supplementation on Gastric Emptying Rate and Gastrointestinal Hormone Responses in Healthy Men

Nutrients ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 258 ◽  
Author(s):  
Adora Yau ◽  
John McLaughlin ◽  
Ronald Maughan ◽  
William Gilmore ◽  
Gethin Evans
Keyword(s):  
Gastric Emptying ◽  
Gastrointestinal Hormone ◽  
Short Term ◽  
Gastric Emptying Rate ◽  
Healthy Men ◽  
Dietary Fructose ◽  
Hormone Responses

scholarly journals Comparable Postprandial Amino Acid and Gastrointestinal Hormone Responses to Beef Steak Cooked Using Different Methods: A Randomised Crossover Trial

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 380 ◽  
Author(s):  
Utpal K. Prodhan ◽  
Shikha Pundir ◽  
Vic S.-C. Chiang ◽  
Amber M. Milan ◽  
Matthew P. G. Barnett ◽  
...  
Keyword(s):  
Cooking Methods ◽  
Gastrointestinal Hormone ◽  
Hormonal Responses ◽  
Flow Cytometric ◽  
Beef Steak ◽  
Hormone Responses ◽  
Glucagon Like Peptide 1 ◽  
Ultrahigh Performance Liquid Chromatography ◽  
Branched Chain ◽  
Insulinotropic Peptide

Cooking changes the texture and tenderness of red meat, which may influence its digestibility, circulatory amino acids (AA) and gastrointestinal (GI) hormonal responses in consumers. In a randomised crossover intervention, healthy males (n = 12) consumed a beef steak sandwich, in which the beef was cooked by either a pan-fried (PF) or sous-vide (SV) method. Plasma AA were measured by ultrahigh performance liquid chromatography (UPLC), while plasma GI hormones were measured using a flow cytometric multiplex array. Following meat ingestion, the circulatory concentrations of some of the essential AA (all the branched-chain AA: leucine, isoleucine and valine; and threonine), some of the nonessential AA (glycine, alanine, tyrosine and proline) and some of the nonproteogenic AA (taurine, citrulline and ornithine) were increased from fasting levels by 120 or 180 min (p < 0.05). There were no differences in circulating AA concentrations between cooking methods. Likewise, of the measured GI hormones, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) concentrations increased from fasting levels after consumption of the steak sandwich (p < 0.05), with no differences between the cooking methods. In the healthy male adults, protein digestion and circulating GI hormone responses to a beef-steak breakfast were unaltered by the different cooking methods.

Gastric emptying of oil and aqueous meal components in pancreatic insufficiency: effects of posture and on appetite

1995 ◽  
Vol 268 (6) ◽  
pp. G925-G932 ◽  
Author(s):  
B. I. Carney ◽  
K. L. Jones ◽  
M. Horowitz ◽  
W. M. Sun ◽  
R. Penagini ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Aqueous Phase ◽  
Pancreatic Insufficiency ◽  
Normal Subjects ◽  
Exocrine Pancreatic Insufficiency ◽  
Exocrine Insufficiency ◽  
Left Lateral Decubitus Position ◽  
Before And After ◽  
Pancreatic Exocrine ◽  
Lateral Decubitus

The aims of this study were to evaluate the effects of posture on gastric emptying, intragastric distribution, and satiation after a meal containing oil and aqueous phases in patients with exocrine pancreatic insufficiency. Five patients with cystic fibrosis (CF) consumed 60 ml 99mTc-labeled (V)-thiocyanate olive oil and 290 ml 113mIn-labeled diethylenetriaminepentaacetic acid soup while sitting and while lying in the left lateral decubitus position. Hunger and fullness before and after the meal were recorded. Results were compared with those obtained in 11 normal volunteers. In both postures emptying of oil was faster (P < 0.01) in CF patients. Emptying of the aqueous phase was faster (P < 0.01) in CF patients in the decubitus position. In normal subjects there was no overall difference in emptying of oil between the two postures, whereas emptying of the aqueous phase was delayed (P < 0.01) in the decubitus position. In CF patients emptying of oil was faster (P < 0.01) in the decubitus position, and emptying of the aqueous phase was only slightly faster (P < 0.05) in the sitting position. For both postures there was greater retention (P < 0.05) of oil in the proximal stomach in normal subjects than CF patients. Hunger decreased (P < 0.05) after the meal in the control subjects, but there was no change in CF patients. These results indicate that in CF patients with pancreatic exocrine insufficiency 1) gastric emptying of nonhomogenized fat is faster than normal, 2) gravity affects gastric emptying of oil, and 3) effects of a fatty meal on hunger are reduced.

Dual effects of cisapride on gastric emptying and antropyloroduodenal motility

1993 ◽  
Vol 264 (2) ◽  
pp. G195-G201 ◽  
Author(s):  
R. Fraser ◽  
M. Horowitz ◽  
A. Maddox ◽  
J. Dent
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Gastric Motility ◽  
Normal Subjects ◽  
Solid Component ◽  
Pressure Waves ◽  
Dual Effect ◽  
Intravenous Saline ◽  
Plausible Mechanism ◽  
Stimulation Of

There is little information about the effects of cisapride on human antropyloroduodenal motility, despite its documented efficacy for increasing the rate of gastric emptying in patients with gastroparesis. Cisapride has been reported to have little effect on gastric emptying in normal subjects. Antral, pyloric, and duodenal pressures were recorded simultaneously with gastric emptying in 20 healthy volunteers. Thirty minutes after the solid component of the meal had started to empty from the stomach, each subject received either 10 mg cisapride i.v. (11 subjects) or intravenous saline (9 subjects). Intravenous saline had no effect on either motility or gastric emptying. In contrast, cisapride administration was associated with a dual effect on motility, with initial suppression of antral pressure waves (P < 0.05) followed by stimulation of associated antropyloroduodenal pressure waves (P < 0.01). Gastric emptying slowed in the first 30 min after cisapride (P < 0.05), and this was followed by more rapid gastric emptying (P < 0.01). The amount of the meal emptied in the 60 min after cisapride correlated with the number of associated antroduodenal pressure waves (r = 0.75, P < 0.001) but not with the number of antral waves (r = 0.42, NS). These results indicate that cisapride in a dose of 10 mg i.v. has dual effects on gastric emptying and gastric motility. The stimulation of associated antral pressure waves is a plausible mechanism for the efficacy of cisapride in the treatment of gastroparesis.

Scintigraphic Evaluation of Gastric Emptying in Obese Patients Submitted to Sleeve Gastrectomy Compared to Normal Subjects

2009 ◽  
Vol 19 (11) ◽  
pp. 1515-1521 ◽  
Author(s):  
Italo Braghetto ◽  
Cristóbal Davanzo ◽  
Owen Korn ◽  
Attila Csendes ◽  
Héctor Valladares ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Gastric Emptying ◽  
Normal Subjects ◽  
Obese Patients

scholarly journals Reproducibility of energy intake, gastric emptying, blood glucose, plasma insulin and cholecystokinin responses in healthy young males

2008 ◽  
Vol 101 (7) ◽  
pp. 1094-1102 ◽  
Author(s):  
Nivasinee S. Nair ◽  
Ixchel M. Brennan ◽  
Tanya J. Little ◽  
Diana Gentilcore ◽  
Trygve Hausken ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Gastric Emptying ◽  
Energy Intake ◽  
Plasma Insulin ◽  
Intraclass Correlation ◽  
Young Male ◽  
Gastrointestinal Hormone ◽  
Hormone Release ◽  
Intraindividual Variation ◽  
Glucose Plasma

Gastric emptying, as well as intragastric meal distribution, and gastrointestinal hormones, including cholecystokinin (CCK), play an important role in appetite regulation. The evaluation of gastrointestinal factors regulating food intake is commonly performed in healthy, lean, young male participants. It has, however, been suggested that there is a marked interindividual variability in the effects of nutrient ‘preloads’ on energy intake in this group. Whether there is significant intraindividual variation in acute energy intake after a nutrient preload, and, if so, how this relates to day-to-day differences in gastric emptying and gastrointestinal hormone release, is unclear. The purpose of the present paper is to evaluate the hypothesis that energy intake after a nutrient preload would be reproducible and associated with reproducible patterns of gastric emptying, intragastric distribution and gastrointestinal hormone release. Fifteen healthy men (age 25 (sem5) years) consumed a glucose preload (50 g glucose in 300 ml water; 815 kJ) on three occasions. Gastric emptying and intragastric meal distribution (using three-dimensional ultrasound), blood glucose, plasma insulin and CCK concentrations and appetite perceptions were evaluated over 90 min, and energy intake from a cold buffet-style meal was then quantified. Energy intake was highly reproducible within individuals between visits (intraclass correlation coefficient,ri = 0·9). Gastric emptying, intragastric meal distribution, blood glucose, plasma insulin and CCK concentrations and appetite perceptions did not differ between visits (ri>0·7 for all). In healthy males, energy intake is highly reproducible, at least in the short term, and is associated with reproducible patterns of gastric emptying, glycaemia, insulinaemia and CCK release.

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