scholarly journals The effect of metformin treatment on gastric acid secretion and gastrointestinal hormone levels in normal subjects

Diabetologia ◽  
1980 ◽  
Vol 19 (2) ◽  
pp. 93-96 ◽  
Author(s):  
A. M. Molloy ◽  
J. Ardill ◽  
G. H. Tomkin
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Normal Subjects ◽  
Gastrointestinal Hormone ◽  
Metformin Treatment ◽  
Hormone Levels

The Effect of Acute Emotional Stress on Gastric Acid Secretion in Normal Subjects and Duodenal Ulcer Patients

1993 ◽  
Vol 17 (2) ◽  
pp. 117-122 ◽  
Author(s):  
William H. Bresnick ◽  
Christian Rask-Madsen ◽  
Daniel L. Hogan ◽  
Michael A. Koss ◽  
Jon I. Isenberg
Keyword(s):  
Duodenal Ulcer ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Emotional Stress ◽  
Normal Subjects ◽  
Acute Emotional Stress

Metabolism and influence of gastrin-52 on gastric acid secretion in humans

1995 ◽  
Vol 269 (4) ◽  
pp. G600-G605 ◽  
Author(s):  
C. P. Hansen ◽  
F. Stadil ◽  
J. F. Rehfeld
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Normal Subjects ◽  
Apparent Volume ◽  
Volume Of Distribution ◽  
Gel Chromatography ◽  
A Minor ◽  
Apparent Volume Of Distribution

It has been shown recently that the two largest alpha-carboxyamidated progastrin products are gastrin-71 and gastrin-52. Human gastrin-52 has now been synthesized, and the effect on gastric acid secretion and elimination from plasma was examined and compared with gastrin-17 in 12 normal subjects. The peptides were infused separately in four consecutive doses; the maximum response of gastrin-17 and gastrin-52 was 25.2 +/- 2.8 and 22.2 +/- 2.8 mmol H+/50 min, respectively (P< 0.01). This difference in efficacy was presumably related to nonequilibrium of gastrin-52 between plasma and receptor. The elimination of gastrin-17 was monoexponential with a half-life of 4.7 +/- 0.3 min; clearance and apparent volume of distribution were 16.7 +/- 1.5 ml.kg-1.min-1 and 106.0 +/- 9.2 ml/kg, respectively. The elimination of gastrin-52 was biexponential, the half-lives were 4.9 +/- 0.7 and 49.9 +/- 4.2 min, and clearance and apparent volume of distribution were 1.9 +/- 0.2 ml.kg-1.min-1 and 106.3 +/- 10.1 ml/kg, respectively. Gel chromatography of plasma samples drawn during infusion of gastrin-52 revealed that most of the immunoreactivity eluted in the position of the intact peptide. Small peaks in the positions of gastrin-34 and the NH2-terminal pentapeptide fragment of gastrin-52 indicate that a minor part of gastrin-52 is degraded to smaller peptides in vivo. It is concluded that gastrin-52 is bioactive with an efficacy close to or similar to that of gastrin-17. A minor fraction of gastrin-52 undergoes postsecretory cleavage either in plasma or after capillary transit.

The Stability of Gastric Acid Secretion during Prolonged Pentagastrin Stimulation in Man

1984 ◽  
Vol 66 (1) ◽  
pp. 99-101 ◽  
Author(s):  
B. Petersen ◽  
J. Christiansen ◽  
P. Kirkegaard ◽  
P. Skov Olsen
Keyword(s):  
Gastric Secretion ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Healthy Subjects ◽  
Acid Output ◽  
Normal Subjects ◽  
The Stability ◽  
Time Required ◽  
H 30

1. Prolonged stimulation with pentagastrin in doses of 100 and 500 ng h−1 kg−1 was performed in nine healthy subjects. 2. A plateau in gastric secretion was reached after 90 min with 100 ng h−1 kg−1 and 500 ng h−1 kg−1 resulted in a secretory plateau after 60 min. 3. When the plateau was reached the acid secretion rate was constant for the rest of the study, that is 4 h after beginning the pentagastrin infusion. Medians and interquartile ranges of acid output were 4.9 (3.7–5.2) and 8.1 (5.8–9.5) mmol of H+/30 min. 4. We conclude that no ‘fade’ of gastric acid secretion occurs during 4 h of submaximal pentagastrin stimulation in normal subjects, and that the time required for reaching a secretory plateau is dependent on the dose of pentagastrin.

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