Effect of bile acids and dietary fat on large bowel carcinogenesis in animal models

1978 ◽  
Vol 13 (3) ◽  
pp. 206-212 ◽  
Author(s):  
Tomio Narisawa ◽  
Bandaru S. Reddy ◽  
John H. Weisburger
Keyword(s):  
Animal Models ◽  
Bile Acids ◽  
Dietary Fat ◽  
Large Bowel

Faecal Lipid Excretion Levels in Normal Japanese Females on an Unrestricted Diet and a Fat-Restricted Diet Measured by Simultaneous Analysis of Faecal Lipids

1992 ◽  
Vol 20 (6) ◽  
pp. 461-466 ◽  
Author(s):  
T Nakamura ◽  
H Kikuchi ◽  
K Takebe ◽  
K Kudoh ◽  
A Terada ◽  
...  
Keyword(s):  
Bile Acids ◽  
Dietary Fat ◽  
Chromatographic Method ◽  
Simultaneous Analysis ◽  
Restricted Diet ◽  
Neutral Sterol ◽  
Neutral Sterols ◽  
Unrestricted Diet ◽  
Lipid Excretion ◽  
Normal Japanese

Faecal lipid excretion was determined in 16 females on an unrestricted diet and on a fat-restricted diet using a chromatographic method for the simultaneous analysis of faecal lipids. The fat-restricted diet reduced the total quantity of faeces and the amounts of fatty acids, neutral sterols and bile acids excreted were almost halved compared with when on an unrestricted diet. This indicates that dietary fat, fibre and cholesterol affect the amount of faecal bile acid, neutral sterol and fatty acid excretion. The amount of cholesterol/animal sterols excreted and the percentage of primary bile acids were, however, similar for both the fat-restricted and unrestricted diets.

The correlation between cholecystectomy and fecal bile acids, and large-bowel cancer induced with 1,2-dimethylhydrazine in mice

1985 ◽  
Vol 28 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Tomio Narisawa ◽  
Masanori Sano ◽  
Makoto Sato ◽  
Toshio Takahashi ◽  
Noritoshi Tanida ◽  
...  
Keyword(s):  
Bile Acids ◽  
Large Bowel ◽  
Bowel Cancer ◽  
Large Bowel Cancer ◽  
Fecal Bile Acids

Bile Acids and Cancer of the Large Bowel

1987 ◽  
Vol 5 (2) ◽  
pp. 65-77 ◽  
Author(s):  
Norbert F. Breuer ◽  
Harald Goebell
Keyword(s):  
Bile Acids ◽  
Large Bowel

FÆCAL BILE-ACIDS AND CLOSTRIDIA IN PATIENTS WITH CANCER OF THE LARGE BOWEL

The Lancet ◽  
1975 ◽  
Vol 305 (7906) ◽  
pp. 535-539 ◽  
Author(s):  
M.J. Hill ◽  
B.S. Drasar ◽  
R.E.O. Williams ◽  
T.W. Meade ◽  
A.G. Cox ◽  
...  
Keyword(s):  
Bile Acids ◽  
Large Bowel ◽  
Patients With Cancer

scholarly journals Hydrothermal treatment of Novelose 330 results in high yield of resistant starch type 3 with beneficial prebiotic properties and decreased secondary bile acid formation in rats

2006 ◽  
Vol 95 (6) ◽  
pp. 1063-1074 ◽  
Author(s):  
Gisela Jacobasch ◽  
Gerhard Dongowski ◽  
Detlef Schmiedl ◽  
Katrin Müller-Schmehl
Keyword(s):  
Bile Acids ◽  
Large Bowel ◽  
Resistant Starch ◽  
Distal Colon ◽  
Proximal Colon ◽  
Secondary Bile Acid ◽  
Mucosal Regeneration ◽  
Wide Range ◽  
Type 3 ◽  
Secondary Bile Acids

Annealing and heat-moisture treatment (HMT) are shown to be suitable methods to increase the yield of resistant starch type 3 (RS3) from Novelose 330 by up to 75%. Peak temperatures of approximately 121°C were used to produce to a sufficiently high thermal stability of the hydrothermal modified RS3 products for a wide range of applications. HMT significantly increased the crystallinity up to 40%.An in vivofeeding experiment with Wistar rats showed that fermentation of Novelose 330 dominated in the proximal colon, but degradation of HMT-Novelose was more dominant in the distal colon, leading to higher butyrate concentrations in this segment of the large bowel. Large-bowel surface and crypt length increased in the proximal colon in rats fed the Novelose 330-containing diet. In contrast, after the intake of HMT-Novelose, maximal values were found in the distal segment. The lower pH and higher butyrate concentration of the caecal and colonic contents significantlysuppressed the formation of secondary bile acids in RS3-fed rats. The formation of secondary bile acids was inhibited more strongly by HMT-Novelose than by Novelose 330. The Ki-67-immunopositive epithelial cells in the colon of RS3-fed rats indicated the establishment of an optimalbalance in the dynamic process of mucosal regeneration. HMT provides a method for the economical production of a high-quality RS3 with dominating prebiotic properties in the distal colon for health-promoting applications.

Hydrophilic bile acids: Prevention and dissolution experiments in two animal models of cholesterol cholelithiasis

Lipids ◽  
1995 ◽  
Vol 30 (9) ◽  
pp. 855-861 ◽  
Author(s):  
Bertram I. Cohen ◽  
Takahiro Mikami ◽  
Nariman Ayyad ◽  
Akira Ohshima ◽  
R. Infante ◽  
...  
Keyword(s):  
Animal Models ◽  
Bile Acids ◽  
Cholesterol Cholelithiasis

scholarly journals The effect of dietary fat on the turnover of cholic acid and on the composition of the biliary bile acids in man.

1965 ◽  
Vol 44 (11) ◽  
pp. 1754-1765 ◽  
Author(s):  
S Lindstedt ◽  
J Avigan ◽  
D S Goodman ◽  
J Sjövall ◽  
D Steinberg
Keyword(s):  
Bile Acids ◽  
Cholic Acid ◽  
Dietary Fat

Fecal Bile Acids and Neutral Sterols in Japanese with Large Bowel Carcinoma

Oncology ◽  
1983 ◽  
Vol 40 (4) ◽  
pp. 255-258 ◽  
Author(s):  
Nobuaki Kaibara ◽  
Toshiaki Sasaki ◽  
Masahide Ikeguchi ◽  
Shigemasa Koga ◽  
Shiro Ikawa
Keyword(s):  
Bile Acids ◽  
Large Bowel ◽  
Fecal Bile Acids ◽  
Neutral Sterols

Metabolism pattern of fecal bile acids in patients with large bowel cancer

1990 ◽  
Vol 2 (4) ◽  
pp. 52-55
Author(s):  
Guonguang Feng ◽  
Xigeng Zhou ◽  
Baoming Yu ◽  
Cairu Dong ◽  
Ruiting Shi ◽  
...  
Keyword(s):  
Bile Acids ◽  
Large Bowel ◽  
Bowel Cancer ◽  
Large Bowel Cancer ◽  
Fecal Bile Acids
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