Hydrophilic bile acids: Prevention and dissolution experiments in two animal models of cholesterol cholelithiasis

Lipids ◽  
1995 ◽  
Vol 30 (9) ◽  
pp. 855-861 ◽  
Author(s):  
Bertram I. Cohen ◽  
Takahiro Mikami ◽  
Nariman Ayyad ◽  
Akira Ohshima ◽  
R. Infante ◽  
...  
Keyword(s):  
Animal Models ◽  
Bile Acids ◽  
Cholesterol Cholelithiasis

Aspirin does not inhibit cholesterol cholelithiasis in two established animal models

1991 ◽  
Vol 101 (4) ◽  
pp. 1109-1116 ◽  
Author(s):  
Bertram I. Cohen ◽  
Erwin H. Mosbach ◽  
Nariman Ayyad ◽  
Michiko Yoshii ◽  
Charles K. McSherry
Keyword(s):  
Animal Models ◽  
Cholesterol Cholelithiasis

Effect of bile acids and dietary fat on large bowel carcinogenesis in animal models

1978 ◽  
Vol 13 (3) ◽  
pp. 206-212 ◽  
Author(s):  
Tomio Narisawa ◽  
Bandaru S. Reddy ◽  
John H. Weisburger
Keyword(s):  
Animal Models ◽  
Bile Acids ◽  
Dietary Fat ◽  
Large Bowel

scholarly journals Circulating bile acids concentration is predictive of coronary artery disease in human

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Caroline Chong Nguyen ◽  
Denis Duboc ◽  
Dominique Rainteau ◽  
Harry Sokol ◽  
Lydie Humbert ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Animal Models ◽  
Bile Acids ◽  
Independent Predictor ◽  
Serum Concentrations ◽  
Gender And Age ◽  
The Mean ◽  
Artery Disease ◽  
Metabolic Liver Diseases

AbstractSynthetized by the liver and metabolized by the gut microbiota, BA are involved in metabolic liver diseases that are associated with cardiovascular disorders. Animal models of atheroma documented a powerful anti-atherosclerotic effect of bile acids (BA). This prospective study examined whether variations in circulating BA are predictive of coronary artery disease (CAD) in human. Consecutive patients undergoing coronary angiography were enrolled. Circulating and fecal BA were measured by high pressure liquid chromatography and tandem mass spectrometry. Of 406 screened patients, 80 were prospectively included and divided in two groups with (n = 45) and without (n = 35) CAD. The mean serum concentration of total BA was twice lower in patients with, versus without CAD (P = 0.005). Adjusted for gender and age, this decrease was an independent predictor of CAD. In a subgroup of 17 patients, statin therapy doubled the serum BA concentration. Decreased serum concentrations of BA were predictors of CAD in humans. A subgroup analysis showed a possible correction by statins. With respect to the anti-atherosclerotic effect of BA in animal models, and their role in human lipid metabolism, this study describe a new metabolic disturbance associated to CAD in human.

scholarly journals Kinetics of Cholesterol and Bile Acids in Patients with Cholesterol Cholelithiasis

1975 ◽  
Vol 69 (2) ◽  
pp. 318-325 ◽  
Author(s):  
Gershon W. Hepner ◽  
Steven H. Quarfordt
Keyword(s):  
Bile Acids ◽  
Kinetics Of ◽  
Cholesterol Cholelithiasis

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

Inflammational Animal Models for Schizophrenia

2015 ◽  
Vol 223 (3) ◽  
pp. 157-164 ◽  
Author(s):  
Georg Juckel
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Immune Activation ◽  
Microglial Activation ◽  
Treatment Options ◽  
Early Adulthood ◽  
Brain Regions ◽  
Synaptic Connections ◽  
Preventive Interventions ◽  
Immunological System

Abstract. Inflammational-immunological processes within the pathophysiology of schizophrenia seem to play an important role. Early signals of neurobiological changes in the embryonal phase of brain in later patients with schizophrenia might lead to activation of the immunological system, for example, of cytokines and microglial cells. Microglia then induces – via the neurotoxic activities of these cells as an overreaction – a rarification of synaptic connections in frontal and temporal brain regions, that is, reduction of the neuropil. Promising inflammational animal models for schizophrenia with high validity can be used today to mimic behavioral as well as neurobiological findings in patients, for example, the well-known neurochemical alterations of dopaminergic, glutamatergic, serotonergic, and other neurotransmitter systems. Also the microglial activation can be modeled well within one of this models, that is, the inflammational PolyI:C animal model of schizophrenia, showing a time peak in late adolescence/early adulthood. The exact mechanism, by which activated microglia cells then triggers further neurodegeneration, must now be investigated in broader detail. Thus, these animal models can be used to understand the pathophysiology of schizophrenia better especially concerning the interaction of immune activation, inflammation, and neurodegeneration. This could also lead to the development of anti-inflammational treatment options and of preventive interventions.

Sex difference in depression: Which animal models mimic it.

2020 ◽  
Vol 134 (3) ◽  
pp. 248-266
Author(s):  
Javed Iqbal ◽  
Frank Adu-Nti ◽  
Xuejiao Wang ◽  
Hui Qiao ◽  
Xin-Ming Ma
Keyword(s):  
Animal Models ◽  
Sex Difference
Sign in / Sign up

Export Citation Format

Share Document