Effect of cell lipid composition on the formation of nonspecific antibiotic resistance in alkanotrophic rhodococci

Microbiology ◽  
2000 ◽  
Vol 69 (1) ◽  
pp. 51-57 ◽  
Author(s):  
M. S. Kuyukina ◽  
I. B. Ivshina ◽  
M. I. Rychkova ◽  
O. B. Chumakov
Keyword(s):  
Antibiotic Resistance ◽  
Lipid Composition ◽  
Cell Lipid

scholarly journals Significance of Lipid Composition in a Blood-Brain Barrier–Mimetic PAMPA Assay

2013 ◽  
Vol 19 (3) ◽  
pp. 437-444 ◽  
Author(s):  
Scott D. Campbell ◽  
Karen J. Regina ◽  
Evan D. Kharasch
Keyword(s):  
Endothelial Cell ◽  
Human Brain ◽  
Blood Brain Barrier ◽  
Lipid Composition ◽  
Brain Barrier ◽  
Brain Lipid ◽  
Passive Permeability ◽  
Whole Brain ◽  
Cell Lipid ◽  
Drug Access

Endothelial cells forming the blood-brain barrier limit drug access into the brain, due to tight junctions, membrane drug transporters, and unique lipid composition. Passive permeability, thought to mediate drug access, is typically tested using porcine whole-brain lipid. However, human endothelial cell lipid composition differs. This investigation evaluated the influence of lipid composition on passive permeability across artificial membranes. Permeability of CNS-active drugs across an immobilized lipid membrane was determined using three lipid models: crude extract from whole pig brain, human brain microvessel lipid, and microvessel lipid plus cholesterol. Lipids were immobilized on polyvinylidene difluoride, forming donor and receiver chambers, in which drug concentrations were measured after 2 h. The log of effective permeability was then calculated using the measured concentrations. Permeability of small, neutral compounds was unaffected by lipid composition. Several structurally diverse drugs were highly permeable in porcine whole-brain lipid but one to two orders of magnitude less permeable across human brain endothelial cell lipid. Inclusion of cholesterol had the greatest influence on bulky amphipathic compounds such as glucuronide conjugates. Lipid composition markedly influences passive permeability. This was most apparent for charged or bulky compounds. These results demonstrate the importance of using species-specific lipid models in passive permeability assays.

Observations préliminaires sur l'accumulation d'hydrocarbures chez Candida steatolytica: relation avec la synthèse des lipides

1985 ◽  
Vol 31 (7) ◽  
pp. 620-624 ◽  
Author(s):  
M. Elisabetta Guerzoni ◽  
Paolo Lambertini ◽  
Agostino Cavazza ◽  
Rosa Marchetti
Keyword(s):  
Carbon Source ◽  
Lipid Composition ◽  
Lipid Accumulation ◽  
Nitrogen Limitation ◽  
Culture Medium ◽  
Lipomyces Starkeyi ◽  
Cell Lipid ◽  
Branched Hydrocarbons ◽  
Lipid Fractions

Different cell lipid accumulation and composition patterns were observed in the yeasts Lipomyces starkeyi and Candida steatolytica by varying the nutritive conditions. In Lipomyces starkeyi 303 which accumulates high levels of lipids as triglycerides, the composition of the different lipid fractions was relatively unaffected by the culture medium. In contrast, the lipid composition of Candida steatolytica 20C was strongly affected by the composition of the medium under conditions of nitrogen limitation and when starch was used as the carbon source, high levels of straight and branched hydrocarbons were observed. [Traduction de l'auteur]

scholarly journals Correlation of Bacterial Lipid Composition with Antibiotic Resistance

1970 ◽  
Vol 101 (3) ◽  
pp. 892-900 ◽  
Author(s):  
June K. Dunnick ◽  
William M. O'Leary
Keyword(s):  
Antibiotic Resistance ◽  
Lipid Composition ◽  
Bacterial Lipid

scholarly journals Dependence of norfloxacin diffusion across bilayers on lipid composition

Soft Matter ◽  
2016 ◽  
Vol 12 (7) ◽  
pp. 2135-2144 ◽  
Author(s):  
Sowmya Purushothaman ◽  
Jehangir Cama ◽  
Ulrich F. Keyser
Keyword(s):  
Antibiotic Resistance ◽  
Lipid Composition ◽  
Lipid Membranes ◽  
Relative Concentration ◽  
Bacterial Membranes

Antibiotic resistance is a major concern in medicine, and a better understanding of the interactions of antibiotics with the lipid molecules found in bacterial membranes is therefore highly desirable. We study the permeation of the antibiotic norfloxacin across vesicle lipid membranes of variable lipid compositions, and show that norfloxacin permeation is dependent on both the type and relative concentration of lipid molecules in the membrane.

2-Hydroxyoleic acid, a potent antitumor drug, induces disorder of cell membranes by altering cell lipid composition

2010 ◽  
Vol 163 ◽  
pp. S29-S30
Author(s):  
M. Laura Martin ◽  
Gwendolyn Barceló-Coblijn ◽  
M. Antònia Noguera-Salvà ◽  
Rodrigo de Almeida ◽  
Pablo V. Escribá
Keyword(s):  
Lipid Composition ◽  
Cell Membranes ◽  
Antitumor Drug ◽  
Cell Lipid

Effect of dietary omega-3 fatty acids on red blood cell lipid composition and plasma metabolites in the cockatiel, Nymphicus hollandicus1

2012 ◽  
Vol 90 (9) ◽  
pp. 3068-3079 ◽  
Author(s):  
C. R. Heinze ◽  
M. G. Hawkins ◽  
L. A. Gillies ◽  
X. Wu ◽  
R.L Walzem ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Lipid Composition ◽  
Plasma Metabolites ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Cell Lipid
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