Singlet oxygen in copper-catalyzed lipid peroxidation in erythrocyte membranes

Lipids ◽  
1984 ◽  
Vol 19 (4) ◽  
pp. 278-284 ◽  
Author(s):  
Ai-Hao Ding ◽  
Phillip C. Chan
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
Erythrocyte Membranes

scholarly journals Comparison of Antioxidants: The Limited Correlation between Various Assays of Antioxidant Activity

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3244
Author(s):  
Katarzyna Naparło ◽  
Mirosław Soszyński ◽  
Grzegorz Bartosz ◽  
Izabela Sadowska-Bartosz
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Free Radical ◽  
Experimental System ◽  
Natural Antioxidants ◽  
Egg Yolk ◽  
Erythrocyte Membranes ◽  
Oxygen Species ◽  
Inhibitory Effects

The inhibitory effects a range of synthetic and natural antioxidants on lipid peroxidation of egg yolk and erythrocyte membranes induced by a free radical generator 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) was compared, with significant differences being found between both systems. When the protection by selected antioxidants against the effects of AAPH on erythrocytes (hemolysis, oxidation of hemoglobin and glutathione (GSH) and generation of reactive oxygen species (ROS)) was studied, most antioxidants were protective, but in some tests (oxidation of hemoglobin and GSH) some acted as prooxidants, inducing oxidation in the absence of AAPH and enhancing the AAPH-induced oxidation. These results demonstrate a diversified action of antioxidants in different systems and point to a need for careful extrapolation of any conclusions drawn from one parameter or experimental system to another.

Lipid Peroxidation and Cherniluminescence during Naproxen Metabolism in Rat Liver Microsomes

1994 ◽  
Vol 13 (12) ◽  
pp. 831-838 ◽  
Author(s):  
Hiroyuki Yokoyama ◽  
Toshiharu Horie ◽  
Shoji Awazu
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Thiobarbituric Acid ◽  
Rat Liver Microsomes ◽  
Oxygen Species ◽  
Thiobarbituric Acid Reactive Substances ◽  
Microsomal Suspension ◽  
Weight Protein

1 Rat liver microsomal suspension containing NADPH and MgCl2 was incubated at 37°C with naproxen, a non-steroidal anti-inflammatory drug. Thiobarbituric acid reactive substances (TBA-RS), high molecular weight protein aggregates and fluorescent substances were formed in the microsomal suspension. 2 Chemiluminescence was produced from the microsomal suspension. This chemiluminescence production was well correlated to the TBA-RS formation, indicating that the chemiluminescence production was closely associated with the lipid peroxidation. 3 The addition of SKF-525A to the microsomal suspension inhibited the production of TBA-RS, chemiluminescence and 6-demethylnaproxen (6-DMN), the oxidative product of naproxen. Further, the antioxidant, α-tocopherol and singlet oxygen quenchers like histidine, dimethylfuran and 1,4-diazabicyclo[2,2,2]octane strikingly inhibited the productions of chemiluminescence and TBA-RS. 4 Neither naproxen nor 6-DMN caused lipid peroxidation in the absence of NADPH. Thus, lipid peroxidation and chemiluminescence during the oxidation of naproxen in liver microsomes was suggested to be provoked by reactive oxygen species and an origin of chemiluminescence was shown to be singlet oxygen.

UVA photoirradiation of retinyl palmitate—Formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation

2006 ◽  
Vol 163 (1) ◽  
pp. 30-43 ◽  
Author(s):  
Qingsu Xia ◽  
Jun Jie Yin ◽  
Shu-Hui Cherng ◽  
Wayne G. Wamer ◽  
Mary Boudreau ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
Retinyl Palmitate

Lipid Peroxidation in Erythrocyte Membranes of Women with Benign and Malignant Neoplasms of the Endometrium

2010 ◽  
Vol 149 (4) ◽  
pp. 437-439 ◽  
Author(s):  
N. V. Solopova ◽  
A. A. Samoylova ◽  
N. M. Titova ◽  
A. A. Savchenko ◽  
T. N. Zamay ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Erythrocyte Membranes ◽  
Malignant Neoplasms

scholarly journals THE EFFECT OF ANTIOXIDANT THERAPY ON THE SEVERITY OF THE COURSE, THERAPY EFFICACY AND DURATION OF REMISSION IN PATIENTS WITH PSORIASIS

2019 ◽  
Vol 19 (2) ◽  
pp. 4-8
Author(s):  
O. Bezeha ◽  
I. Popova
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Properties ◽  
Biologically Active ◽  
Erythrocyte Membranes ◽  
Laboratory Research ◽  
Blood Biochemical ◽  
Integrated Therapy ◽  
Psoriasis Therapy ◽  
Partial Inactivation ◽  
Active Substances

The prevalence of psoriasis has accentuated the high relevance of searching new approaches towards its treatments. This article describes the connection between the development of the clinical picture and lipid peroxidation, and studies the expediency of using drugs with antioxidant properties as a component of the treatment. The products of lipid peroxidation regulate cell proliferation and permeability of cell membranes, thus the function and structure of the skin is directly dependent on the level of lipids and phospholipids. Patients with either mild or severe psoriasis have been found out to demonstrate some changes in the blood serum: increased cholesterol, triglycerides and free fatty acids, as well as a change in the ratio of the fractional content of phospholipids in erythrocyte membranes. Taking into account the above mentioned factors of psoriasis, we can suggest that it would be reasonable to include antioxidants into the integrated therapy. Antioxidants are the group of biologically active substances that possess an ability to interact with various reactogenic oxidants, reactive oxygen species and other free radicals that leads to their full or partial inactivation. During this study resveratrol was added to standard psoriasis therapy. The scope of laboratory research included: diagnosis of changes in the blood biochemical analysis taken on an empty stomach in the morning to investigate the content of total protein, albumin, bilirubin, low and high density lipids, phospholipids, cholesterol, alanine aminotransferase, aspartate aminotransferase. It has been found out the reduction of symptom in the patients who received complex therapy modified with resveratrol was more marked than in patients who received standard therapy only. A more intensive decrease in infiltration, erythema, desquamation, and itching has been clinically observed as well.

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