scholarly journals UVA Photoirradiation of Oxygenated Benz[a]anthracene and 3-Methylcholanthene - Generation of Singlet Oxygen and Induction of Lipid Peroxidation

2008 ◽  
Vol 5 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Jun-Jie Yin ◽  
Qingsu Xia ◽  
Shu-Hui Cherng ◽  
I-Wah Tang ◽  
Peter Fu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen

Lipid Peroxidation and Cherniluminescence during Naproxen Metabolism in Rat Liver Microsomes

1994 ◽  
Vol 13 (12) ◽  
pp. 831-838 ◽  
Author(s):  
Hiroyuki Yokoyama ◽  
Toshiharu Horie ◽  
Shoji Awazu
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Thiobarbituric Acid ◽  
Rat Liver Microsomes ◽  
Oxygen Species ◽  
Thiobarbituric Acid Reactive Substances ◽  
Microsomal Suspension ◽  
Weight Protein

1 Rat liver microsomal suspension containing NADPH and MgCl2 was incubated at 37°C with naproxen, a non-steroidal anti-inflammatory drug. Thiobarbituric acid reactive substances (TBA-RS), high molecular weight protein aggregates and fluorescent substances were formed in the microsomal suspension. 2 Chemiluminescence was produced from the microsomal suspension. This chemiluminescence production was well correlated to the TBA-RS formation, indicating that the chemiluminescence production was closely associated with the lipid peroxidation. 3 The addition of SKF-525A to the microsomal suspension inhibited the production of TBA-RS, chemiluminescence and 6-demethylnaproxen (6-DMN), the oxidative product of naproxen. Further, the antioxidant, α-tocopherol and singlet oxygen quenchers like histidine, dimethylfuran and 1,4-diazabicyclo[2,2,2]octane strikingly inhibited the productions of chemiluminescence and TBA-RS. 4 Neither naproxen nor 6-DMN caused lipid peroxidation in the absence of NADPH. Thus, lipid peroxidation and chemiluminescence during the oxidation of naproxen in liver microsomes was suggested to be provoked by reactive oxygen species and an origin of chemiluminescence was shown to be singlet oxygen.

Singlet oxygen in copper-catalyzed lipid peroxidation in erythrocyte membranes

Lipids ◽  
1984 ◽  
Vol 19 (4) ◽  
pp. 278-284 ◽  
Author(s):  
Ai-Hao Ding ◽  
Phillip C. Chan
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
Erythrocyte Membranes

UVA photoirradiation of retinyl palmitate—Formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation

2006 ◽  
Vol 163 (1) ◽  
pp. 30-43 ◽  
Author(s):  
Qingsu Xia ◽  
Jun Jie Yin ◽  
Shu-Hui Cherng ◽  
Wayne G. Wamer ◽  
Mary Boudreau ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
Retinyl Palmitate

scholarly journals Phototoxicity of Kava — Formation of Reactive Oxygen Species Leading to Lipid Peroxidation and DNA Damage

2012 ◽  
Vol 40 (06) ◽  
pp. 1271-1288 ◽  
Author(s):  
Qingsu Xia ◽  
Hsiu-Mei Chiang ◽  
Yu-Ting Zhou ◽  
Jun-Jie Yin ◽  
Fang Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
The United States ◽  
Oxygen Species ◽  
Uva Irradiation ◽  
Skin Keratinocytes ◽  
Spin Resonance ◽  
Dna Strand

Kava is one of the most widely sold herbal dietary supplements in the United States. It has been reported that, besides exhibiting hepatotoxicity, kava also possesses photosensitivity and induces dermopathy in humans. In this study, we determined that UVA irradiation of kava in the presence of a lipid, methyl linoleate, generated lipid peroxidation which was mediated by singlet oxygen generated during photoirradiation. The six major kavalactones(yangonin, 7,8-dihydrokawa in, kawain, 7,8-dihydromethysticin, methysticin, and 5,6-dehydrokawain) were also studied in parallel; only 5,6-dehydrokawain and yangonin-induced a low level of lipid peroxidation. UVA irradiation of kava in human HaCaT skin keratinocytes induced cytotoxicity which was mediated by oxidative stress, led to DNA strand cleavage, and produced 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct. Study by the electron spin resonance (ESR) method revealed that UVA irradiation of kava produced singlet oxygen and carbon-centered radicals. The overall results suggest that kava is photocytotoxic and photogenotoxic, both mediated by free radicals generated during photoirradiation.

Rate constants for quenching singlet oxygen and activities for inhibiting lipid peroxidation of carotenoids and α-tocopherol in liposomes

Lipids ◽  
1998 ◽  
Vol 33 (8) ◽  
pp. 751-756 ◽  
Author(s):  
Kenji Fukuzawa ◽  
Yasuki Inokami ◽  
Akira Tokumura ◽  
Junji Terao ◽  
Asahi Suzuki
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
Rate Constants

scholarly journals Singlet oxygen in copper-catalyzed lipid peroxidation

Lipids ◽  
1984 ◽  
Vol 19 (6) ◽  
pp. 465-465 ◽  
Author(s):  
A. -H. Ding ◽  
P. C. Chan
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen

THE ROLE OF SUPEROXIDE AND SINGLET OXYGEN IN LIPID PEROXIDATION

1978 ◽  
Vol 28 (4-5) ◽  
pp. 803-809 ◽  
Author(s):  
Bruce A. Svingen ◽  
Fredrick O. O'Neal ◽  
Steven D. Aust
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen
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