Evaluation of plasma glutathione S-transferase-π (GST-π) as a tumor marker for oral squamous cell carcinoma

1996 ◽  
Vol 1 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Yutaka Kobayashi ◽  
Teruo Amagasa ◽  
Eiji Fujii ◽  
Masashi Yamashiro
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Glutathione S Transferase ◽  
Plasma Glutathione

scholarly journals Oncofetal Protein CR-1 in a new clinical role: a potential tumor marker for Oral Squamous Cell Carcinoma

2019 ◽  
Author(s):  
Jain Anu ◽  
Mallupattu Sumanth Kumar ◽  
Thakur Reetu ◽  
Mohindra Satyawati ◽  
Bal Amanjit ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Sandwich Elisa ◽  
Post Treatment ◽  
Serum Samples ◽  
Clinical Role

AbstractPURPOSECR-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancers, which is the sixth most common cancer around the world, particularly with high prevalence in developing countries. Oral squamous cell carcinoma (OSCC) is the most predominant (90%) of all the histological types of oral cancer. Late detection, associated with increased morbidity and mortality, is mainly attributed to non-availability of a suitable biomarker for the disease. In the present pilot study we have evaluated the role of soluble CR-1, in serum as a potential tumor marker for OSCC.METHODSCR-1 was estimated using sandwich ELISA in serum samples of 50 biopsy proven OSCC patients (pre and post treatment) along with age and gender matched healthy controls. Immunohistochemistry was also done in corresponding tumor tissue sections to check the expression of CR-1.RESULTSPre-treatment CR-1 was found to be 2.25 fold higher in serum of OSCC patients as compared to control (p<0.0001***), which was reduced to 1.6 folds post treatment (p=0.0006***). CR-1 levels were comparatively higher in early stage of disease. Upon IHC 80% of the cases were found to be positive for CR-1.CONCLUSIONThis study provides evidence that serum levels of CR-1 are elevated in patients of Oral Squamous Cell Carcinoma, which decrease post treatment. Also, the association of expression of protein with tumor progression predicts CR-1 as a molecule that can be further evaluated as a potential tumor maker in OSCC.

Serum autoantibody to sideroflexin 3 as a novel tumor marker for oral squamous cell carcinoma

2008 ◽  
Vol 2 (4) ◽  
pp. 517-527 ◽  
Author(s):  
Ryuichi Murase ◽  
Yasuhito Abe ◽  
Takashi Takeuchi ◽  
Motowo Nabeta ◽  
Yoshinori Imai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Autoantibody

scholarly journals The synergy of tobacco and alcohol and glutathione S-transferase θ 1 gene deletion and oral squamous cell carcinoma

2016 ◽  
Vol 20 (3) ◽  
pp. 348
Author(s):  
K Paremala ◽  
Sarah D′ Mello ◽  
RadhikaManoj Bavle ◽  
Soumya Makarla ◽  
M Sudhakara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gene Deletion ◽  
Glutathione S Transferase

scholarly journals Human Glutathione S-transferase A1 polymorphism and susceptibility to oral squamous cell carcinoma in Japanese

2005 ◽  
Vol 10 (6) ◽  
pp. 331-334 ◽  
Author(s):  
Yasuhiro Komiya ◽  
Yoshiki Kuroda ◽  
Hiroyuki Nakao ◽  
Katsuyuki Arizono ◽  
Ai Nakahara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Glutathione S Transferase

scholarly journals Periostin – an unexplored tumor marker of oral squamous cell carcinoma

2020 ◽  
Vol 7 (4) ◽  
pp. 383-395
Author(s):  
Khushboo Desai ◽  
◽  
Dolly Patel ◽  
Parth Desai ◽  
Rakesh Rawal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell
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