Serum autoantibody to sideroflexin 3 as a novel tumor marker for oral squamous cell carcinoma

2008 ◽  
Vol 2 (4) ◽  
pp. 517-527 ◽  
Author(s):  
Ryuichi Murase ◽  
Yasuhito Abe ◽  
Takashi Takeuchi ◽  
Motowo Nabeta ◽  
Yoshinori Imai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Autoantibody

scholarly journals Oncofetal Protein CR-1 in a new clinical role: a potential tumor marker for Oral Squamous Cell Carcinoma

2019 ◽  
Author(s):  
Jain Anu ◽  
Mallupattu Sumanth Kumar ◽  
Thakur Reetu ◽  
Mohindra Satyawati ◽  
Bal Amanjit ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Sandwich Elisa ◽  
Post Treatment ◽  
Serum Samples ◽  
Clinical Role

AbstractPURPOSECR-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancers, which is the sixth most common cancer around the world, particularly with high prevalence in developing countries. Oral squamous cell carcinoma (OSCC) is the most predominant (90%) of all the histological types of oral cancer. Late detection, associated with increased morbidity and mortality, is mainly attributed to non-availability of a suitable biomarker for the disease. In the present pilot study we have evaluated the role of soluble CR-1, in serum as a potential tumor marker for OSCC.METHODSCR-1 was estimated using sandwich ELISA in serum samples of 50 biopsy proven OSCC patients (pre and post treatment) along with age and gender matched healthy controls. Immunohistochemistry was also done in corresponding tumor tissue sections to check the expression of CR-1.RESULTSPre-treatment CR-1 was found to be 2.25 fold higher in serum of OSCC patients as compared to control (p<0.0001***), which was reduced to 1.6 folds post treatment (p=0.0006***). CR-1 levels were comparatively higher in early stage of disease. Upon IHC 80% of the cases were found to be positive for CR-1.CONCLUSIONThis study provides evidence that serum levels of CR-1 are elevated in patients of Oral Squamous Cell Carcinoma, which decrease post treatment. Also, the association of expression of protein with tumor progression predicts CR-1 as a molecule that can be further evaluated as a potential tumor maker in OSCC.

scholarly journals Periostin – an unexplored tumor marker of oral squamous cell carcinoma

2020 ◽  
Vol 7 (4) ◽  
pp. 383-395
Author(s):  
Khushboo Desai ◽  
◽  
Dolly Patel ◽  
Parth Desai ◽  
Rakesh Rawal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Serum Fragment of Cytokeratin Subunit 19 as a Tumor Marker in Primary Oral Squamous Cell Carcinoma

1997 ◽  
Vol 51 (3) ◽  
pp. 369-374
Author(s):  
Hideo Kurokawa ◽  
Yuka Maruoka ◽  
Tomoyuki Murata ◽  
Yoshihiro Yamashita ◽  
Keiko Miura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Identification of SPRR3 as a novel diagnostic/prognostic biomarker for oral squamous cell carcinoma via RNA sequencing and bioinformatic analyses

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9393
Author(s):  
Lu Yu ◽  
Zongcheng Yang ◽  
Yingjiao Liu ◽  
Fen Liu ◽  
Wenjing Shang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Candidate Genes ◽  
Squamous Cell ◽  
Prognostic Biomarker ◽  
Interaction Network ◽  
Normal Tissues ◽  
Small Proline Rich Protein

Oral squamous cell carcinoma (OSCC) has always been one of the most aggressive and invasive cancers among oral and maxillofacial malignancies. As the morbidity and mortality of the disease have increased year by year, the search for a promising diagnostic and prognostic biomarker for the disease is becoming increasingly urgent. Tumorous and adjacent tissues were collected from three OSCC sufferers and we obtained 229 differentially expressed genes (DEGs) between tumor and normal tissues via high-throughput RNA sequence. Function and pathway enrichment analyses for DEGs were conducted to find a correlation between tumorigenesis status and DEGs. Protein interaction network and molecular complex detection (MCODE) were constructed to detect core modules. Two modules were enriched in MCODE. The diagnostic and prognostic values of the candidate genes were analyzed, which provided evidence for the candidate genes as new tumor markers. Small Proline Rich Protein 3 (SPRR3), a potential tumor marker that may be useful for the diagnosis of OSCC, was screened out. The survival analysis showed that SPRR3 under expression predicted the poor prognosis of OSCC patients. Further experiments have also shown that the expression of SPRR3 decreased as the malignancy of OSCC increased. Therefore, we believe that SPRR3 could be used as a novel diagnostic and prognostic tumor marker.

Role of Oncofetal Protein CR-1 as a Potential Tumor Marker for Oral Squamous Cell Carcinoma

2020 ◽  
Author(s):  
Anu Jain ◽  
Sumanth Kumar Mallupattu ◽  
Reetu Thakur ◽  
Satyawati Mohindra ◽  
Amanjit Bal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell

Serum fragment of cytokeratin subunit 19 (Cyfra) as a tumor marker in diagnosis and monitoring of treatment of oral squamous cell carcinoma

1999 ◽  
Vol 4 (1) ◽  
pp. 17-21 ◽  
Author(s):  
H. Kurokawa ◽  
Shingo Tokudome ◽  
Yoshihiro Yamashita ◽  
Hiroaki Ishibashi ◽  
Tsutomu Yoshikawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell
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