scholarly journals Clinical Study on Serum Fragment of Cytokeratin Subunit 19 (Cyfra) as a Tumor Marker of Patients with Oral Squamous Cell Carcinoma

1995 ◽  
Vol 49 (5) ◽  
pp. 399-407
Author(s):  
Toshiyuki Maegawa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Study ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Oncofetal Protein CR-1 in a new clinical role: a potential tumor marker for Oral Squamous Cell Carcinoma

2019 ◽  
Author(s):  
Jain Anu ◽  
Mallupattu Sumanth Kumar ◽  
Thakur Reetu ◽  
Mohindra Satyawati ◽  
Bal Amanjit ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Sandwich Elisa ◽  
Post Treatment ◽  
Serum Samples ◽  
Clinical Role

AbstractPURPOSECR-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancers, which is the sixth most common cancer around the world, particularly with high prevalence in developing countries. Oral squamous cell carcinoma (OSCC) is the most predominant (90%) of all the histological types of oral cancer. Late detection, associated with increased morbidity and mortality, is mainly attributed to non-availability of a suitable biomarker for the disease. In the present pilot study we have evaluated the role of soluble CR-1, in serum as a potential tumor marker for OSCC.METHODSCR-1 was estimated using sandwich ELISA in serum samples of 50 biopsy proven OSCC patients (pre and post treatment) along with age and gender matched healthy controls. Immunohistochemistry was also done in corresponding tumor tissue sections to check the expression of CR-1.RESULTSPre-treatment CR-1 was found to be 2.25 fold higher in serum of OSCC patients as compared to control (p<0.0001***), which was reduced to 1.6 folds post treatment (p=0.0006***). CR-1 levels were comparatively higher in early stage of disease. Upon IHC 80% of the cases were found to be positive for CR-1.CONCLUSIONThis study provides evidence that serum levels of CR-1 are elevated in patients of Oral Squamous Cell Carcinoma, which decrease post treatment. Also, the association of expression of protein with tumor progression predicts CR-1 as a molecule that can be further evaluated as a potential tumor maker in OSCC.

scholarly journals CLINICAL STUDY ON ORAL SQUAMOUS CELL CARCINOMA PATIENTS 80 YEARS OF AGE AND OLDER

2000 ◽  
Vol 26 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Ichiro OGURA ◽  
Tadashi WADAMORI ◽  
Ryozo MIYAMOTO ◽  
Takeshi MIYAKURA ◽  
Takao WATANABE ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

Clinical study of multiple primary and double cancers including oral squamous cell carcinoma

2012 ◽  
Vol 24 (4) ◽  
pp. 189-194 ◽  
Author(s):  
Nobuharu Yamamoto ◽  
Takeshi Okubo ◽  
Takumi Sakuma ◽  
Keisuke Sugahara ◽  
Masae Yamamoto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Multiple Primary ◽  
Double Cancers

Serum autoantibody to sideroflexin 3 as a novel tumor marker for oral squamous cell carcinoma

2008 ◽  
Vol 2 (4) ◽  
pp. 517-527 ◽  
Author(s):  
Ryuichi Murase ◽  
Yasuhito Abe ◽  
Takashi Takeuchi ◽  
Motowo Nabeta ◽  
Yoshinori Imai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Autoantibody

scholarly journals A clinical study of patients aged 75 and older with oral squamous cell carcinoma

2012 ◽  
Vol 24 (3) ◽  
pp. 103-111 ◽  
Author(s):  
Shoko Yoshida ◽  
Koji Kishimoto ◽  
Soichiro Ibaragi ◽  
Shohei Domae ◽  
Norie Yoshioka ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell
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