Assessment of working memory in rats using spatial alternation behavior with variable retention intervals: effects of fixed-ratio size and scopolamine

1990 ◽  
Vol 100 (4) ◽  
pp. 491-497 ◽  
Author(s):  
Harlan E. Shannon ◽  
Kerry G. Bemis ◽  
John C. Hart
Keyword(s):  
Working Memory ◽  
Fixed Ratio ◽  
Alternation Behavior ◽  
Spatial Alternation ◽  
Variable Retention ◽  
Ratio Size ◽  
Retention Intervals

Exploring the role of context-dependent hippocampal activity in spatial alternation behavior

Hippocampus ◽  
2007 ◽  
Vol 17 (10) ◽  
pp. 988-1002 ◽  
Author(s):  
James A. Ainge ◽  
Matthijs A.A. van der Meer ◽  
Rosamund F. Langston ◽  
Emma R. Wood
Keyword(s):  
Alternation Behavior ◽  
Spatial Alternation ◽  
Hippocampal Activity ◽  
Context Dependent

scholarly journals Dorsal Hippocampus Not Always Necessary in a Radial Arm Maze Delayed Win-shift Task

2018 ◽  
Author(s):  
Dylan Layfield ◽  
Nathan Sidell ◽  
Afnan Abdullahi ◽  
Ehren L. Newman
Keyword(s):  
Working Memory ◽  
Test Performance ◽  
Spatial Working Memory ◽  
Dorsal Hippocampus ◽  
Radial Arm Maze ◽  
Spatial Coding ◽  
Shift Task ◽  
Neural Underpinnings ◽  
Retention Intervals ◽  
Phosphate Buffered Saline

AbstractSpatial working memory is important for foraging and navigating the environment. However, its neural underpinnings remain poorly understood. The hippocampus, known for its spatial coding and involvement in spatial memory, is widely understood to be necessary for spatial working memory when retention intervals increase beyond seconds into minutes. Here, we describe new evidence that the dorsal hippocampus is not always necessary for spatial working memory for retention intervals of 8 minutes. Rats were trained to perform a delayed spatial win shift radial arm maze task (DSWS) with an 8-minute delay between study and test phases. We then tested whether bilateral inactivation of the dorsal hippocampus between the study and test phases impaired behavioral performance at test. Inactivation was achieved through a bilateral infusion of lidocaine. Performance following lidocaine was compared to control trials, in which, sterile phosphate buffered saline (PBS) was infused. Test performance did not differ between the lidocaine and PBS conditions, remaining high in each. To explore the possibility that this insensitivity to inactivation was a result of overtraining, a second cohort of animals received substantially less training prior to the infusions. In this second cohort, lidocaine infusions did significantly impair task performance. These data indicate that successful performance of a spatial win-shift task on the 8-arm maze need not always be hippocampally dependent.

Interactive Effects of Fixed-Ratio Size and Number of Food Pellets Per Fixed Ratio on Rats’ Food-Reinforced Behavior

1988 ◽  
Vol 38 (1) ◽  
pp. 121-143 ◽  
Author(s):  
Dale J. Kliner ◽  
Gregory A. Lemaire ◽  
Richard A. Meisch
Keyword(s):  
Fixed Ratio ◽  
Interactive Effects ◽  
Ratio Size
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