Photodynamic therapy in the treatment of malignant tumours of the upper aerodigestive tract

1989 ◽  
Vol 4 (4) ◽  
pp. 279-284 ◽  
Author(s):  
F. Calzavara ◽  
L. Tomio ◽  
L. Norberto ◽  
A. Peracchia ◽  
L. Corti ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aerodigestive Tract ◽  
Malignant Tumours ◽  
Upper Aerodigestive Tract

scholarly journals Minor Salivary Gland Tumours of Upper Aerodigestive Tract: A Clinicopathological Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Grażyna Wyszyńska-Pawelec ◽  
Michał Gontarz ◽  
Jan Zapała ◽  
Mariusz Szuta
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Relative Survival ◽  
Aerodigestive Tract ◽  
Malignant Tumours ◽  
Upper Aerodigestive Tract ◽  
Female Ratio ◽  
Salivary Gland Tumours ◽  
Results Of Treatment ◽  
Radial Forearm

The aim of this retrospective study of 56 patients with minor salivary gland tumours (MSGTs) of the upper aerodigestive tract is to present demographic features, distribution of tumours as well as methods and results of treatment performed in our institution over a 10-year period. Of 221 patients with salivary gland tumours, 56 patients with MSGT were selected. There were 36 female and 20 male patients aged from 8 to 81 years. Male-to-female ratio was 1 : 2 in the group of benign MSGT and 1 : 1.7 in the group of malignant tumours. The palate was the most frequent site of MSGT (45.6%), followed by buccal mucosa (19.3%). Of all MSGTs 63.2% were malignant, and 36.8% were benign. Adenoid cystic carcinoma was the most common neoplasm (31.6%), followed by pleomorphic adenoma (29.8%). Surgery was the method of choice in the treatment of patients with MSGT. Postoperative defects were reconstructed by prosthetic obturators, local flaps, and free radial forearm flap. Relative survival for patients with malignant MSGT was 88% at three years and 71.5% at five years. MSGTs are more frequent in females and predominantly affect the palate. Malignant MSGTs are more common than benign.

Photodynamic therapy in the upper aerodigestive tract. Overview and outlook

2016 ◽  
Vol 9 (11-12) ◽  
pp. 1302-1313 ◽  
Author(s):  
Veronika Volgger ◽  
Christian Stephan Betz
Keyword(s):  
Photodynamic Therapy ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract

scholarly journals Photodynamic Therapy for 101 Early Cancers of the Upper Aerodigestive Tract, the Esophagus, and the Bronchi: A Single-Institution Experience

1999 ◽  
Vol 5 (3) ◽  
pp. 145-154 ◽  
Author(s):  
A. Radu ◽  
P. Grosjean ◽  
Ch. Fontolliet ◽  
G. Wagnieres ◽  
A. Woodtli ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Early Stage ◽  
Red Light ◽  
Green Light ◽  
Tracheobronchial Tree ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Photofrin Ii ◽  
Significant Difference ◽  
Radical Therapy

Cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical therapy. We report on the results of our clinical experience with photodynamic therapy (PDT) for the treatment of early carcinomas in the upper aerodigestive tract, the esophagus, and the tracheobronchial tree. Sixty-four patients with 101 squamous cell carcinomas were treated with three different photosensitizers: hematoporphyrin derivative (HPD), Photofrin II, and tetra (m-hydroxyphenyl)chlorin (mTHPC). Seventy-seven (76%) tumors showed a complete rsponse with no recurrence after a mean follow-up period of 27 months. There was no significant difference in terms of cure rates among the three dyes. However, mTHPC has a stronger phototoxicity and induces a shorter skin photosensitization than either of the other photosensitizers. There were eight major complications: three esophagotracheal fistulae after illumination with red light in the esophagus, two esophageal stenoses following 360° circumferential irradiation, and three bronchial stenoses. Illumination with the less penetrating green light and the use of a 180° or 240° windowed cylindrical light distributor render the risk of complications in the esophagus essentially impossible, without reducing the efficacy of the treatment. Therefore, PDT may be considered as a safe and effective treatment for early carcinomas of the upper aerodigestive tract, the esophagus, and the tracheobronchial tree.

Photodynamic Therapy for Cancer of the Upper Aerodigestive Tract Using Tetra(m-hydroxyphenyl)chlorin

1996 ◽  
Vol 14 (5) ◽  
pp. 281-287 ◽  
Author(s):  
PIERRE GROSJEAN ◽  
JEAN-FRANÇOIS SAVARY ◽  
JÉRÔME MIZERET ◽  
GEORGES WAGNIERES ◽  
ALAIN WOODTLI ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract

Multiple primary malignancies in patients with malignant tumours of the nasal cavities and paranasal sinuses

1990 ◽  
Vol 104 (9) ◽  
pp. 696-698 ◽  
Author(s):  
Mamoru Miyaguchi ◽  
Shun-ichi Sakai ◽  
Nozomu Mori ◽  
Shigeo Kitaoku
Keyword(s):  
Paranasal Sinuses ◽  
Aerodigestive Tract ◽  
Second Cancer ◽  
Second Malignancies ◽  
Malignant Tumours ◽  
Upper Aerodigestive Tract ◽  
Nasal Cavities ◽  
Multiple Primary Malignancies ◽  
Multiple Primary

AbstractThe incidence of multiple primary malignancies (MPM) was analysed in 1297 patients with malignant tumours of the nasal cavities and paranasal sinuses. The patients were followed for a minimum of six years or until death. The incidence of MPM was 3.4 per cent (44/1297) which is lower than in patients with malignant tumours of other regions in the upper aerodigestive tract. Five of the 44 patients had second malignancies within previously irradiated areas. There was a difference between the proportion of histologies occurring in irradiated tissues compared with the overall 1297 patients. This finding suggests that radiotherapy may induce a second cancer.

Toxicity of photodynamic therapy after combined external beam radiotherapy and intraluminal brachytherapy for carcinoma of the upper aerodigestive tract

2001 ◽  
Vol 28 (3) ◽  
pp. 278-281 ◽  
Author(s):  
Nicholas J. Sanfilippo ◽  
Alex Hsi ◽  
Albert S. DeNittis ◽  
Gregory G. Ginsberg ◽  
Michael L. Kochman ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
External Beam Radiotherapy ◽  
Aerodigestive Tract ◽  
External Beam ◽  
Upper Aerodigestive Tract ◽  
Intraluminal Brachytherapy
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