Photodynamic therapy in the upper aerodigestive tract. Overview and outlook

2016 ◽  
Vol 9 (11-12) ◽  
pp. 1302-1313 ◽  
Author(s):  
Veronika Volgger ◽  
Christian Stephan Betz
Keyword(s):  
Photodynamic Therapy ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract

scholarly journals Photodynamic Therapy for 101 Early Cancers of the Upper Aerodigestive Tract, the Esophagus, and the Bronchi: A Single-Institution Experience

1999 ◽  
Vol 5 (3) ◽  
pp. 145-154 ◽  
Author(s):  
A. Radu ◽  
P. Grosjean ◽  
Ch. Fontolliet ◽  
G. Wagnieres ◽  
A. Woodtli ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Early Stage ◽  
Red Light ◽  
Green Light ◽  
Tracheobronchial Tree ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Photofrin Ii ◽  
Significant Difference ◽  
Radical Therapy

Cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical therapy. We report on the results of our clinical experience with photodynamic therapy (PDT) for the treatment of early carcinomas in the upper aerodigestive tract, the esophagus, and the tracheobronchial tree. Sixty-four patients with 101 squamous cell carcinomas were treated with three different photosensitizers: hematoporphyrin derivative (HPD), Photofrin II, and tetra (m-hydroxyphenyl)chlorin (mTHPC). Seventy-seven (76%) tumors showed a complete rsponse with no recurrence after a mean follow-up period of 27 months. There was no significant difference in terms of cure rates among the three dyes. However, mTHPC has a stronger phototoxicity and induces a shorter skin photosensitization than either of the other photosensitizers. There were eight major complications: three esophagotracheal fistulae after illumination with red light in the esophagus, two esophageal stenoses following 360° circumferential irradiation, and three bronchial stenoses. Illumination with the less penetrating green light and the use of a 180° or 240° windowed cylindrical light distributor render the risk of complications in the esophagus essentially impossible, without reducing the efficacy of the treatment. Therefore, PDT may be considered as a safe and effective treatment for early carcinomas of the upper aerodigestive tract, the esophagus, and the tracheobronchial tree.

Photodynamic Therapy for Cancer of the Upper Aerodigestive Tract Using Tetra(m-hydroxyphenyl)chlorin

1996 ◽  
Vol 14 (5) ◽  
pp. 281-287 ◽  
Author(s):  
PIERRE GROSJEAN ◽  
JEAN-FRANÇOIS SAVARY ◽  
JÉRÔME MIZERET ◽  
GEORGES WAGNIERES ◽  
ALAIN WOODTLI ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract

Toxicity of photodynamic therapy after combined external beam radiotherapy and intraluminal brachytherapy for carcinoma of the upper aerodigestive tract

2001 ◽  
Vol 28 (3) ◽  
pp. 278-281 ◽  
Author(s):  
Nicholas J. Sanfilippo ◽  
Alex Hsi ◽  
Albert S. DeNittis ◽  
Gregory G. Ginsberg ◽  
Michael L. Kochman ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
External Beam Radiotherapy ◽  
Aerodigestive Tract ◽  
External Beam ◽  
Upper Aerodigestive Tract ◽  
Intraluminal Brachytherapy

Photodynamic therapy in the treatment of malignant tumours of the upper aerodigestive tract

1989 ◽  
Vol 4 (4) ◽  
pp. 279-284 ◽  
Author(s):  
F. Calzavara ◽  
L. Tomio ◽  
L. Norberto ◽  
A. Peracchia ◽  
L. Corti ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aerodigestive Tract ◽  
Malignant Tumours ◽  
Upper Aerodigestive Tract
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