Use of natural surfactant in an HIV-infected infant withPneumocystis carinii pneumonia

1996 ◽  
Vol 22 (6) ◽  
pp. 611-612 ◽  
Author(s):  
S. C. Marriage ◽  
H. Underhill ◽  
S. Nadel
Keyword(s):  
Infected Infant ◽  
Natural Surfactant

Natural surfactant combined with beclomethasone decreases oxidative lung injury in the preterm lamb

2009 ◽  
Vol 44 (12) ◽  
pp. 1159-1167 ◽  
Author(s):  
Carlo Dani ◽  
Iuri Corsini ◽  
Silvia Burchielli ◽  
Valentina Cangiamila ◽  
Mariangela Longini ◽  
...  
Keyword(s):  
Lung Injury ◽  
Natural Surfactant

scholarly journals The Natural Surfactant Glycerol Monolaurate Significantly Reduces Development ofStaphylococcus aureusandEnterococcus faecalisBiofilms

2015 ◽  
Vol 16 (5) ◽  
pp. 538-542 ◽  
Author(s):  
Donavon J. Hess ◽  
Michelle J. Henry-Stanley ◽  
Carol L. Wells
Keyword(s):  
Natural Surfactant ◽  
Glycerol Monolaurate

Regression of attained milestones in an HIV infected Infant

2001 ◽  
Vol 68 (10) ◽  
pp. 991-994
Author(s):  
Purnima Madhivanan ◽  
S. N. Mothi ◽  
N. Kumarasamy ◽  
Tokugha Yepthomi ◽  
John Lambert ◽  
...  
Keyword(s):  
Infected Infant

Surfactant for Hyaline Membrane Disease

PEDIATRICS ◽  
1980 ◽  
Vol 66 (5) ◽  
pp. 795-798 ◽  
Author(s):  
Tetsuro Fujiwara ◽  
Forrest H. Adams
Keyword(s):  
Premature Infants ◽  
Lung Surfactant ◽  
Hyaline Membrane Disease ◽  
The Other ◽  
Synthetic Surfactant ◽  
Natural Surfactant ◽  
Hyaline Membrane ◽  
Dipalmitoyl Lecithin ◽  
Air Intake ◽  
Relative Deficiency

Since it has been demonstrated that hyaline membrane disease (HMD) is due to a relative deficiency of lung surfactant,1,2 one possible approach to the treatment or prevention of HMD in premature infants might be the introduction of surfactant into the lungs. Thus far, attempts at aerosolization of either synthetic surfactant (dipalmitoyl lecithin [DPL]) or natural surfactant into the lungs of patients or animals have failed to produce convincing benefits.3-5 On the other hand, direct instillation of a solution of natural surfactant into the trachea seems to produce striking results. Enhörning et al6 were the first to show that tracheal deposition of natural surfactant into premature rabbit fetuses before the first breath enhanced air intake and improved the pressure-volume relationships of the lungs; it also increased their survival time.7

Lung volumes and alveolar expansion pattern in immature rabbits treated with serum-diluted surfactant

2004 ◽  
Vol 97 (4) ◽  
pp. 1408-1413 ◽  
Author(s):  
Yongmei Xu ◽  
Tsutomu Kobayashi ◽  
Xiaoguang Cui ◽  
Keisuke Ohta ◽  
Chiharu Kabata ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Ringer Solution ◽  
Natural Surfactant ◽  
Volume Curve ◽  
Pressure Volume Curve ◽  
Expansion Pattern

In acute respiratory distress syndrome, mechanical ventilation often induces alveolar overdistension aggravating the primary insult. To examine the mechanism of overdistension, surfactant-deficient immature rabbits were anesthetized with pentobarbital sodium, and their lungs were treated with serum-diluted modified natural surfactant (porcine lung extract; 2 mg/ml, 10 ml/kg). By mechanical ventilation with a peak inspiration pressure of 22.5 cmH2O, the animals had a tidal volume of 14.7 ml/kg (mean), when 2.5 cmH2O positive end-expiratory pressure was added. This volume was similar to that in animals treated with nondiluted modified natural surfactant (24 mg/ml in Ringer solution, 10 ml/kg). However, the lungs fixed at 10 cmH2O on the deflation limbs of the pressure-volume curve had the largest alveolar/alveolar duct profiles (≥48,000 μm2), accounting for 38% of the terminal air spaces, and the smallest (<6,000 μm2), accounting for 31%. These values were higher than those in animals treated with nondiluted modified natural surfactant ( P < 0.05). We conclude that administration of serum-diluted surfactant to immature neonatal lungs leads to patchy overdistension of terminal air spaces, similar to the expansion pattern that may be seen after dilution of endogenous surfactant with proteinaceous edema fluid in acute respiratory distress syndrome.

scholarly journals Artificial surfactant and natural surfactant. Comparative study of the effects on premature rabbit lungs.

1980 ◽  
Vol 55 (10) ◽  
pp. 758-765 ◽  
Author(s):  
C Morley ◽  
B Robertson ◽  
B Lachmann ◽  
R Nilsson ◽  
A Bangham ◽  
...  
Keyword(s):  
Comparative Study ◽  
Natural Surfactant ◽  
Artificial Surfactant

Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability

2008 ◽  
Vol 29 (9) ◽  
pp. 1276-1287 ◽  
Author(s):  
Snezana Savic ◽  
Slobodanka Tamburic ◽  
Andjelka Kovacevic ◽  
Rolf Daniels ◽  
Christel Müller-Goymann
Keyword(s):  
Physical Stability ◽  
Colloidal Structure ◽  
Pharmaceutical Excipients ◽  
Natural Surfactant ◽  
Emulsion Systems
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