scholarly journals The Natural Surfactant Glycerol Monolaurate Significantly Reduces Development ofStaphylococcus aureusandEnterococcus faecalisBiofilms

2015 ◽  
Vol 16 (5) ◽  
pp. 538-542 ◽  
Author(s):  
Donavon J. Hess ◽  
Michelle J. Henry-Stanley ◽  
Carol L. Wells
Keyword(s):  
Natural Surfactant ◽  
Glycerol Monolaurate

scholarly journals Antibacterial Synergy of Glycerol Monolaurate and Aminoglycosides in Staphylococcus aureus Biofilms

2014 ◽  
Vol 58 (11) ◽  
pp. 6970-6973 ◽  
Author(s):  
Donavon J. Hess ◽  
Michelle J. Henry-Stanley ◽  
Carol L. Wells
Keyword(s):  
Staphylococcus Aureus ◽  
Lauric Acid ◽  
Antimicrobial Properties ◽  
Planktonic Cells ◽  
Antibiotic Resistant ◽  
Content Type ◽  
Natural Surfactant ◽  
Glycerol Monolaurate ◽  
Biofilm Bacteria

ABSTRACTGlycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistantStaphylococcus aureusbiofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.

scholarly journals High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights into Its Antimicrobial Potential

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1981 ◽  
Author(s):  
Qiufen Mo ◽  
Aikun Fu ◽  
Lingli Deng ◽  
Minjie Zhao ◽  
Yang Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Systemic Inflammation ◽  
Body Weight Gain ◽  
High Dose ◽  
Dependent Manner ◽  
Glucose And Lipid Metabolism ◽  
Glycerol Monolaurate ◽  
Indigenous Microbiota ◽  
Anti Inflammatory ◽  
Dose Dependent

Glycerol monolaurate (GML) has potent antimicrobial and anti-inflammatory activities. The present study aimed to assess the dose-dependent antimicrobial-effects of GML on the gut microbiota, glucose and lipid metabolism and inflammatory response in C57BL/6 mice. Mice were fed on diets supplemented with GML at dose of 400, 800 and 1600 mg kg−1 for 4 months, respectively. Results showed that supplementation of GML, regardless of the dosages, induced modest body weight gain without affecting epididymal/brown fat pad, lipid profiles and glycemic markers. A high dose of GML (1600 mg kg−1) showed positive impacts on the anti-inflammatory TGF-β1 and IL-22. GML modulated the indigenous microbiota in a dose-dependent manner. It was found that 400 and 800 mg kg−1 GML improved the richness of Barnesiella, whereas a high dosage of GML (1600 mg kg−1) significantly increased the relative abundances of Clostridium XIVa, Oscillibacter and Parasutterella. The present work indicated that GML could upregulate the favorable microbial taxa without inducing systemic inflammation and dysfunction of glucose and lipid metabolism.

scholarly journals Glycerol Monolaurate Antibacterial Activity in Broth and Biofilm Cultures

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40350 ◽  
Author(s):  
Patrick M. Schlievert ◽  
Marnie L. Peterson
Keyword(s):  
Antibacterial Activity ◽  
Glycerol Monolaurate

Natural surfactant combined with beclomethasone decreases oxidative lung injury in the preterm lamb

2009 ◽  
Vol 44 (12) ◽  
pp. 1159-1167 ◽  
Author(s):  
Carlo Dani ◽  
Iuri Corsini ◽  
Silvia Burchielli ◽  
Valentina Cangiamila ◽  
Mariangela Longini ◽  
...  
Keyword(s):  
Lung Injury ◽  
Natural Surfactant

Bactericidal effect of glycerol monolaurate complex disinfectants on Salmonella of chicken

2021 ◽  
pp. 109150
Author(s):  
Qing Chen ◽  
Yaxin Liu ◽  
Ziyi Zhang ◽  
Ke Li ◽  
Bin Liu ◽  
...  
Keyword(s):  
Bactericidal Effect ◽  
Glycerol Monolaurate
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