Natural surfactant combined with beclomethasone decreases oxidative lung injury in the preterm lamb

2009 ◽  
Vol 44 (12) ◽  
pp. 1159-1167 ◽  
Author(s):  
Carlo Dani ◽  
Iuri Corsini ◽  
Silvia Burchielli ◽  
Valentina Cangiamila ◽  
Mariangela Longini ◽  
...  
Keyword(s):  
Lung Injury ◽  
Natural Surfactant

Natural surfactant and hyperoxic lung injury in primates. II. Morphometric analyses

1994 ◽  
Vol 76 (3) ◽  
pp. 1002-1010 ◽  
Author(s):  
P. J. Fracica ◽  
S. P. Caminiti ◽  
C. A. Piantadosi ◽  
F. G. Duhaylongsod ◽  
J. D. Crapo ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Epithelial Cells ◽  
Lung Injury ◽  
Type I ◽  
Fibroblast Proliferation ◽  
Surfactant Treatment ◽  
Natural Surfactant ◽  
Hyperoxic Lung Injury ◽  
Diffuse Lung

Diffuse lung injury is accompanied by low compliance and hypoxemia with histological evidence of endothelial and alveolar epithelial cell disruption. The histological effects of treatment of an acute diffuse lung injury with a natural surfactant product were evaluated in a primate model because surfactant function and content have been shown to be abnormal in diffuse lung injury in both animals and humans. Ten baboons were ventilated with 100% O2 for 96 h, and 5 were given an aerosol of natural porcine surfactant. Physiological and biochemical measurements of the effects of hyperoxia and surfactant treatment are presented in a companion paper. After O2 exposure, lungs were fixed and processed for quantitative electron microscopy. The responses to O2 included epithelial and endothelial cell injuries, interstitial edema, and inflammation. The hyperoxic animals treated with surfactant were compared with the untreated animals; the treatments altered neutrophil distribution, fibroblast proliferation, and changes in the volumes of type I epithelial cells and endothelial cells. Surfactant-treated animals also had decreased lamellar body volume density in type II epithelial cells and preservation of endothelial cell integrity. These changes suggest complex effects of natural surfactant on the pulmonary response to hyperoxia, including protection against epithelial and endothelial cell destruction as well as significant interstitial inflammation and fibroblast proliferation. We conclude that natural surfactant treatment of hyperoxic lung injury in primates resulted in partial protection of epithelial and endothelial cells but also increased the accumulation of fibroblasts in the lung.

Natural surfactant combined with superoxide dismutase and catalase decreases oxidative lung injury in the preterm lamb

2013 ◽  
Vol 49 (9) ◽  
pp. 898-904 ◽  
Author(s):  
Carlo Dani ◽  
Iuri Corsini ◽  
Mariangela Longini ◽  
Silvia Burchielli ◽  
Giulia Dichiara ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Lung Injury ◽  
Natural Surfactant

scholarly journals Effect of recombinant SP-C surfactant in a porcine lavage model of acute lung injury

2000 ◽  
Vol 88 (2) ◽  
pp. 674-681 ◽  
Author(s):  
R. G. Spragg ◽  
R. M. Smith ◽  
K. Harris ◽  
J. Lewis ◽  
D. Häfner ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Intratracheal Instillation ◽  
Dipalmitoyl Phosphatidylcholine ◽  
Natural Surfactant ◽  
Hyaline Membrane ◽  
Surfactant Apoprotein ◽  
Saline Lavage ◽  
Synthetic Surfactants

Synthetic surfactants allow examination of the effects of specific components of natural surfactant. To determine whether surfactant containing apoprotein C, dipalmitoyl-phosphatidylcholine, phosphatidylglycerol, and palmitic acid restores gas-exchanging function in acute lung injury (ALI), we administered such surfactant (in doses of 50 or 100 mg/kg and in volumes from 1 to 6 ml/kg) or phospholipid (PL) alone, by intratracheal instillation, to pigs with ALI induced by massive saline lavage. Animals ventilated with 100% O2 and receiving 1, 2, 4, or 6 ml/kg of 50 mg/kg recombinant surfactant apoprotein C (rSP-C) surfactant or 2 ml/kg of 50 mg/kg PL (control) had mean arterial[Formula: see text] values, 4 h after treatment, of 230, 332, 130, 142, or 86 Torr, respectively. Animals receiving 1, 2, or 4 ml/kg of 100 mg/kg rSP-C surfactant or 2 ml/kg of 100 mg/kg PL (control) had mean arterial[Formula: see text] values of 197, 214, 148, or 88 Torr, respectively. Surfactant PL distribution was homogeneous. Hyaline membrane formation was reduced in treated animals. Thus, in this model of ALI, rSP-C with PL has the capacity to improve gas exchange and possibly modify lung injury.

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