Genetic analysis of mitomycin C-hypersensitive Chinese hamster cell mutants

Mutagenesis ◽  
1994 ◽  
Vol 9 (5) ◽  
pp. 477-482 ◽  
Author(s):  
Nigel J. Jones
Keyword(s):  
Genetic Analysis ◽  
Mitomycin C ◽  
Chinese Hamster ◽  
Chinese Hamster Cell

Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: A new complementation group with chromosomal instability

1993 ◽  
Vol 19 (5) ◽  
pp. 431-437 ◽  
Author(s):  
W. J. I. Overkamp ◽  
M. A. Rooimans ◽  
I. Neuteboom ◽  
P. Telleman ◽  
F. Arwert ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Mitomycin C ◽  
Chromosomal Instability ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Complementation Group

Involvement of apoptosis in mitomycin C hypersensitivity of Chinese hamster cell mutants

2000 ◽  
Vol 59 (9) ◽  
pp. 1101-1107 ◽  
Author(s):  
Efterpi Papouli ◽  
Corinne Lafon ◽  
Annie Valette ◽  
Malgorzata Z Zdzienicka ◽  
Martine Defais ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Chinese Hamster ◽  
Chinese Hamster Cell

2,4-Dichlorophenol and MCPA in a V79 Test

1988 ◽  
Vol 15 (3) ◽  
pp. 245-250
Author(s):  
Geirid Fiskesjö
Keyword(s):  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Test System ◽  
Similar Degree ◽  
Human Beings ◽  
Industrial Chemicals ◽  
Allium Test ◽  
Chinese Hamster Cell Line ◽  
A Cell ◽  
Mutagenic Effects

Two industrial chemicals, 2,4-dichlorophenol and 4-chloro-2-methylphenoxyacetic acid (MCPA), which have no toxic effects on the Chinese hamster cell line V79 alone, were tested for toxicity and mutagenicity in a cell-mediated test, where mixed-function oxidase (MFO) enzymes are active in the metabolism of xenobiotics. For 2,4-dichlorophenol, a dose-dependent toxicity as well as a slight mutagenicity could be shown when oxygenation enzymes were present. A similar degree of toxicity in a plant test system (the Allium test) indicates a similar risk of damage from exposure to dichlorophenol treatments in both these systems. MCPA did not induce any toxic or mutagenic effects at the concentrations tested. These results were not in agreement with previous results in plant material, where MCPA was clearly toxic at relatively low doses. However, since chlorophenols have been found in plants sprayed with phenoxyacetic acids, further investigations should be performed concerning potential risk to human beings.

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