Rhesus-like antigenic activity manifested in red blood cells of rhesus-negative blood donors and increased expression of ABO antigens after UV-irradiation of blood

1985 ◽  
Vol 99 (4) ◽  
pp. 486-488
Author(s):  
K. A. Samoilova ◽  
K. N. Klimova ◽  
L. S. Priezzheva ◽  
R. A. Artsishevskaya
Keyword(s):  
Red Blood Cells ◽  
Uv Irradiation ◽  
Blood Cells ◽  
Blood Donors ◽  
Antigenic Activity

scholarly journals Ethyl glucuronide, a marker of alcohol consumption, correlates with metabolic markers of oxidant stress but not with hemolysis in stored red blood cells from healthy blood donors

Transfusion ◽  
2020 ◽  
Vol 60 (6) ◽  
pp. 1183-1196 ◽  
Author(s):  
Angelo D'Alessandro ◽  
Xiaoyun Fu ◽  
Julie A. Reisz ◽  
Mars Stone ◽  
Steve Kleinman ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Donors ◽  
Oxidant Stress ◽  
Ethyl Glucuronide ◽  
Metabolic Markers

scholarly journals Testing for Partial RhD with a D-Screen Diagast Kit in Moroccan Blood Donors with Weak D Expression

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Z. Kabiri ◽  
M. Benajiba ◽  
K. Hajjout ◽  
N. Dakka ◽  
H. Bellaoui
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Donors ◽  
Formal Argument ◽  
Appropriate Care ◽  
Specific Reactions ◽  
D Antigen

The aim of this study was to search for the partial D phenotype in Moroccan blood donors with weak D expression. The study included 32 samples with weak D phenotype, and partial D category red blood cells were detected with the D-Screen Diagast kit, which consists in 9 monoclonal anti-D antibodies specific for the most common categories of partial D. Among the 32 samples studied, we identified 13 specific reactions to a partial D antigen (3 DVI, 2 DVa, 2 DIII(a,b,c), and 6 DVII), with 8 reactions suggesting a weak D and 11 reactions providing no formal argument in favor of a partial D antigen. This work can be used to validate the performance of the anti-D reagent and to improve the safety of transfusion of red blood cells from donors expressing the partial D antigen by integrating the finding into the recipient file with a recommendation concerning the appropriate care.

Cell-Derived Microparticles in Blood Products from Thalassemic Blood Donors

2020 ◽  
Author(s):  
Egarit Noulsri ◽  
Surada Lerdwana ◽  
Duangdao Palasuwan ◽  
Attakorn Palasuwan
Keyword(s):  
Flow Cytometry ◽  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Blood Donors ◽  
Blood Components ◽  
Blood Products ◽  
Packed Red Blood Cells ◽  
Thalassemia Trait ◽  
Routine Procedures

Abstract Objective To determine the number of cell-derived microparticles (MPs) in blood products obtained from donors who have thalassemia. Methods Packed red blood cells (PRBCs), plasma, and platelet concentrate (PC) were prepared according to routine procedures. We used flow cytometry to quantitate the concentration of MPs. Results The results of a comparison of MP levels in unprocessed whole blood showed that the concentration of all MPs in the donors without thalassemia trait (n = 255) was higher than in donors with thalassemia trait (n = 70). After processing, increased concentrations of MPs were documented in both groups. Among the blood components, PRBC showed higher platelet-derived MP concentrations in donors with thalassemia than in donors without thalassemia. However, PC showed higher concentrations of total MPs in donors without thalassemia than in donors with that condition. Conclusions Our results suggest little influence of thalassemia-trait status on changes in MP concentrations in blood components.

Indicators of red blood in donors working in enterprises with harmful production

2020 ◽  
pp. 48-52
Author(s):  
A. V. Elifanov ◽  
O. N. Lepunova ◽  
O. V. Frolova ◽  
O. L. Kovyazina ◽  
A. D. Shalabodov
Keyword(s):  
Red Blood Cells ◽  
Working Conditions ◽  
Blood Cells ◽  
Blood Donors ◽  
Hemoglobin Concentration ◽  
Blood Parameters ◽  
Blood System ◽  
Conflict Of Interests ◽  
Subjective Assessments ◽  
Gender And Age

The study of the movement of donation in enterprises with harmful working conditions in Tyumen. The influence of professional factors on red blood parameters (hemoglobin concentration, number of red blood cells, ESR, hematocrit, color index) of donors with regard to gender and age was studied. According to the results of a survey of 4,267 blood donors in 2013–2016, there was an increase in the number of withdrawals from donations, due to changes in red blood indicators, in workers at enterprises with harmful working conditions. The examined men and women, whose work is associated with harmful occupational factors, showed a significant decrease in the concentration of hemoglobin and the number of red blood cells. Objective hematological observations along with subjective assessments of the donors ‘own health showed the development of anemic syndrome — one of the main syndromes of lead professional pathology. It is necessary to continue searching for factors that cause an increase in the percentage of donor withdrawal due to low hemoglobin concentrations. Among the promising measures for maintaining and developing donation in enterprises with harmful working conditions, specific plans for improving health should be developed, including specific tools and conditions for improving the blood system.Funding. The study had no funding.Conflict of interests. The authors declare no conflict of interests.

scholarly journals Hepatitis B Virus Infection and Biomarkers Correlates of Liver Injury among Healthy Blood Donors in Nigeria

2020 ◽  
pp. 69-78
Author(s):  
Ahaneku Iherue Osuji ◽  
Nneka Regina Agbakoba ◽  
Martin Ositaodinma Ifeanyichukwu ◽  
Ifeoma Enweani ◽  
Idris Nasir Abdullahi
Keyword(s):  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Donors ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
B Virus ◽  
The Mean

Objectives: Destruction of blood cells and damage to hepatocytes are the hallmark of hepatitis B viral infection. This cross-sectional study was undertaken to evaluate some hematological parameters and biomarkers of liver injury in healthy blood donors infected with the occult and overt hepatitis B attending the University of Abuja Teaching Hospital (UATH) and Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi, Nigeria.  Materials and Methods: A total of 20 overt and 14 occult hepatitis B virus-infected blood donors were confirmed and enrolled using Roche ® COBAS q-PCR from 212 consented pooled subjects. Hematological parameters and absolute CD4+ T-cell count were determined using the Sysmex hematology analyzer and Partec cyflow counter, respectively. Determination of serum Alanine Aminotransferase (ALT) and Alpha Feto-protein (AFP) levels were done spectrophotometrically and ELISA, respectively.  Results: The mean red blood cells, hematocrit, hemoglobin, white blood cells, CD4 and platelet count in the overt group were not statistically significantly different from the occult group p>0.05. However, of the 34 infected subjects, 7 (20.6%), 6 (17.7%), 2 (5.9%), 13 (38.2%), 2 (5.9%) and 4 (11.8%) had abnormally low blood values for red blood cells, white blood cells, hematocrit, hemoglobin, CD4 and platelets respectively. The mean ALT and ALP values from the occult and overt groups were not also significantly different (p>0.05).  Conclusion: This study found a decrease in the values of some blood cells. However, no significant changes in the liver enzymes were found. These infected individuals should be managed to prevent transmission of HBV infection to other people and subsequent destruction of blood cells and damage to liver cells. Future studies could focus on patients with chronic liver diseases/Hepatocellular carcinoma caused by HBV to determine the effects on the liver biomarkers and hematological parameters.

scholarly journals Rare blood donors with irregular antibodies

2013 ◽  
Vol 66 (7-8) ◽  
pp. 331-334
Author(s):  
Mirjana Krga-Milanovic ◽  
Nevenka Bujandric ◽  
Natasa Milosavljevic-Knezevic
Keyword(s):  
Blood Transfusion ◽  
Red Blood Cells ◽  
Blood Group ◽  
Blood Donor ◽  
Blood Cells ◽  
High Frequency ◽  
Blood Donors ◽  
Blood Groups ◽  
Blood Group System ◽  
Group System

Introduction. Blood groups are inherited biological characteristics that do not change throughout life in healthy people. Blood groups represent antigens found on the surface of red blood cells. Kell blood group system consists of 31 antigens. Kell antigen (K) is present in 0.2% of the population (the rare blood group). Cellano antigen is present in more than 99% (the high-frequency antigen). These antigens have a distinct ability to cause an immune response in the people after blood transfusion or pregnancy who, otherwise, did not have them before. Case Report. This paper presents a blood donor with a rare blood group, who was found to have an irregular antibody against red blood cells by indirect antiglobulin test. Further testing determined the specificity of antibody to be anti-Cellano. The detected antibody was found in high titers (1024) with erythrocyte phenotype Kell-Cellano+. The blood donor was found to have a rare blood group KellKell. This donor was excluded from further blood donation. It is difficult to find compatible blood for a person who has developed an antibody to the high-frequency antigen. The donor?s family members were tested and Cellano antigen was detected in her husband and child. A potential blood donor was not found among the family members. There was only one blood donor in the Register of blood donors who was compatible in the ABO and Kell blood group system. Conclusion. For the successful management of blood transfusion it is necessary to establish a unified national register of donors of rare blood groups and cooperate with the International Blood Group Reference Laboratory in Bristol with the database that registers donors of rare blood groups from around the world.

Sign in / Sign up

Export Citation Format

Share Document