Relationship of structure to antimicrobial activity in anionic surfactants

1985 ◽  
Vol 19 (11) ◽  
pp. 797-802 ◽  
Author(s):  
B. V. Passet ◽  
A. A. Golubyatnikova ◽  
N. V. Enina ◽  
S. V. Nekrasov ◽  
E. T. Mordvinova
Keyword(s):  
Antimicrobial Activity ◽  
Anionic Surfactants ◽  
Relationship Of

SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF NEW BENZIMIDAZOLE DERIVATIVES AS ANTIMICROBIAL AGENTS

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (03) ◽  
pp. 25-29
Author(s):  
S. G Jadhav ◽  
◽  
S. R. Pattan
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Antimicrobial Agents ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Benzimidazole Derivatives ◽  
Structure Activity ◽  
Relationship Of

A new series of substituted benzimidazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral data. The title compounds were evaluated for antimicrobial activity. Some of these compounds have shown excellent antimicrobial activity.

Antimicrobial Activity of Kaurane Diterpenes against Oral Pathogens

2008 ◽  
Vol 63 (5-6) ◽  
pp. 326-330 ◽  
Author(s):  
Sergio R. Ambrosio ◽  
Niege A. J. C. Furtado ◽  
Dionéia C. R. de Oliveira ◽  
Fernando B. da Costa ◽  
Carlos H. G. Martins ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Lactobacillus Casei ◽  
Periodontal Diseases ◽  
Significant Activity ◽  
Streptococcus Sobrinus ◽  
Methyl Ester Derivative ◽  
Structure Activity ◽  
Structural Differences ◽  
Oral Pathogens ◽  
Relationship Of

Two kaurane diterpenes, ent-kaur-16(17)-en-19-oic acid (KA) and 15-β-isovaleryloxy-entkaur- 16(17)-en-19-oic acid (KA-Ival), isolated from Aspilia foliacea, and the methyl ester derivative of KA (KA-Me) were evaluated against oral pathogens. KA was the most active compound, with MIC values of 10 μg mL-1 against the following microorganisms: Streptococcus sobrinus, Streptococcus mutans, Streptococcus mitis, Streptococcus sanguinis, and Lactobacillus casei. However, KA did not show significant activity against Streptococcus salivarius and Enterococcus faecalis, with MIC values equal to 100 and 200 μg mL-1, respectively. Our results show that KA has potential to be used as a prototype for the discovery of new effective anti-infection agents against microorganisms responsible for caries and periodontal diseases. Moreover, these results allow to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to studies on the structure-activity relationship of this type of metabolites with respect to caries and periodontal diseases.

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