Structure–Function Relationship of a Novel PR-5 Protein with Antimicrobial Activity from Soy Hulls

2016 ◽  
Vol 64 (4) ◽  
pp. 948-959 ◽  
Author(s):  
Chun Liu ◽  
Fenfen Cheng ◽  
Yingen Sun ◽  
Hongyu Ma ◽  
Xiaoquan Yang
Keyword(s):  
Antimicrobial Activity ◽  
Structure Function ◽  
Structure Function Relationship ◽  
Soy Hulls ◽  
Function Relationship ◽  
Relationship Of

scholarly journals Elucidating the Structure-Function Relationship of Solvent and Cross-Linker on Affinity-Based Release from Cyclodextrin Hydrogels

Gels ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 9 ◽  
Author(s):  
Sean T. Zuckerman ◽  
Edgardo Rivera-Delgado ◽  
Rebecca M. Haley ◽  
Julius N. Korley ◽  
Horst A. von Recum
Keyword(s):  
Antimicrobial Activity ◽  
Structure Function ◽  
Solvent Polarity ◽  
Affinity Group ◽  
Structure Function Relationship ◽  
Spectrum Activity ◽  
Ethanol Blends ◽  
Hydrogel Swelling ◽  
Function Relationship ◽  
Relationship Of

Minocycline (MNC) is a tetracycline antibiotic capable of associating with cyclodextrin (CD), and it is a frontline drug for many instances of implant infection. Due to its broad-spectrum activity and long half-life, MNC represents an ideal drug for localized delivery; however, classic polymer formulations, particularly hydrogels, result in biphasic release less suitable for sustained anti-microbial action. A polymer delivery system capable of sustained, steady drug delivery rates poses an attractive target to maximize the antimicrobial activity of MNC. Here, we formed insoluble hydrogels of polymerized CD (pCD) with a range of crosslinking densities, and then assessed loading, release, and antimicrobial activity of MNC. MNC loads between 5–12 wt % and releases from pCD hydrogels for >14 days. pCD loaded with MNC shows extended antimicrobial activity against S. aureus for >40 days and E. coli for >70 days. We evaluated a range of water/ethanol blends to test our hypothesis that solvent polarity will impact drug-CD association as a function of hydrogel swelling and crosslinking. Increased polymer crosslinking and decreased solvent polarity both reduced MNC loading, but solvent polarity showed a dramatic reduction independent of hydrogel swelling. Due to its high solubility and excellent delivery profile, MNC represents a unique drug to probe the structure-function relationship between drug, affinity group, and polymer crosslinking ratio.

Role of aromatic residues in the structure-function relationship of .alpha.-bungarotoxin

Biochemistry ◽  
1982 ◽  
Vol 21 (11) ◽  
pp. 2592-2600 ◽  
Author(s):  
Yee Hsiung Chen ◽  
Jang Chyi Tai ◽  
Wan Jen Huang ◽  
Ming Zong Lai ◽  
Mien Chie Hung ◽  
...  
Keyword(s):  
Structure Function ◽  
Aromatic Residues ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Alpha Bungarotoxin ◽  
Relationship Of

Gene cloning and structure - function relationship of cytokines such as TNF and interleukins

1987 ◽  
Vol 16 (3-4) ◽  
pp. 219-226 ◽  
Author(s):  
Walter Fiers ◽  
Rudi Beyaert ◽  
Peter Brouckaert ◽  
Bart Everaerdt ◽  
Guy Haegeman ◽  
...  
Keyword(s):  
Structure Function ◽  
Gene Cloning ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of

scholarly journals Distribution and Structure-Function Relationship of Myosin Heavy Chain Isoforms in the Adult Mouse Heart

2007 ◽  
Vol 282 (33) ◽  
pp. 24057-24064 ◽  
Author(s):  
Maike Krenz ◽  
Sakthivel Sadayappan ◽  
Hanna E. Osinska ◽  
Jeffrey A. Henry ◽  
Samantha Beck ◽  
...  
Keyword(s):  
Structure Function ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Adult Mouse ◽  
Myosin Heavy Chain Isoforms ◽  
Mouse Heart ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of
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