scholarly journals Isolation and characterization of mutants of the facultative methylotroph Arthrobacter P1 blocked in one-carbon metabolism

1987 ◽  
Vol 146 (4) ◽  
pp. 346-352 ◽  
Author(s):  
P. R. Levering ◽  
L. Tiesma ◽  
J. P. Woldendorp ◽  
M. Steensma ◽  
L. Dijkhuizen
Keyword(s):  
Carbon Metabolism ◽  
Arthrobacter P1 ◽  
Facultative Methylotroph ◽  
Isolation And Characterization ◽  
One Carbon Metabolism

ISOLATION AND CHARACTERIZATION OF SIX cDNAs INVOLVED IN CARBON METABOLISM IN LAMINARIA DIGITATA (PHAEOPHYCEAE)

1999 ◽  
Vol 35 (6) ◽  
pp. 1237-1245 ◽  
Author(s):  
Pascale Moulin ◽  
Florent Crépineau ◽  
Bernard Kloareg ◽  
Catherine Boyen
Keyword(s):  
Carbon Metabolism ◽  
Laminaria Digitata ◽  
Isolation And Characterization

Canadian Society of Plant Physiologists Gold Medal Review / Synthèse médaillée d'or de la Société canadienne physiologie végétaleThe fascinating world of folate and one-carbon metabolism

2000 ◽  
Vol 78 (6) ◽  
pp. 691-708 ◽  
Author(s):  
Edwin A Cossins
Keyword(s):  
Carbon Metabolism ◽  
De Novo ◽  
Normal Growth ◽  
Gold Medal ◽  
Animal Cells ◽  
Isolation And Characterization ◽  
Folate Biosynthesis ◽  
One Carbon Metabolism ◽  
Société Canadienne ◽  
Antifolate Drugs

Folate was first isolated from spinach leaves in 1941 and characterized as pteroylglutamic acid. Although plants, fungi, and bacteria synthesize folate de novo, animal cells lack key enzymes of the folate biosynthetic pathway and a dietary source of folate is required for normal growth and development. Folates have importance in human nutrition, health, and disease, and antifolate drugs are commonly used in cancer chemotherapy. In the majority of living cells folates occur as one-carbon substituted tetrahydropteroylpolyglutamate derivatives. These folates donate one-carbon groups during the synthesis of purines, formylmethionyl-tRNA, thymidylate, serine, and methionine. In the last 30 years, research on the folate biochemistry of plant species has intensified and been aided by the development of improved methods for folate isolation and characterization. These studies have resulted in basic information on the nature of plant folylpolyglutamates, folate biosynthesis, the enzymology of several folate-dependent reactions, and the roles of chloroplasts, mitochondria, and the cytosol in the pathways of one-carbon metabolism.Key words: plants, folates, folate biosynthesis, folate-dependent enzymes, one-carbon metabolism.

Characterization and identification of Pseudomonas strain WRF

1994 ◽  
Vol 40 (2) ◽  
pp. 152-154
Author(s):  
Robert S. Fulghum
Keyword(s):  
Pseudomonas Putida ◽  
Key Words ◽  
Carbon Metabolism ◽  
Culture Collection ◽  
American Type Culture Collection ◽  
Phenotypic Characterization ◽  
One Carbon Metabolism

Phenotypic characterization of Pseudomonas strain WRF shows it to be a member of Pseudomonas putida most closely resembling biovar A. The organism has been deposited in the American Type Culture Collection as ATCC 35546.Key words: Pseudomonas WRF characterization, Pseudomonas putida, one-carbon metabolism, siderophores, peptide-bound flavin enzymes.

The isolation and characterization of 18 equine microsatellite loci, TKY272–TKY289

2000 ◽  
Vol 31 (2) ◽  
pp. 149-149 ◽  
Author(s):  
T Tozaki ◽  
H Kakoi ◽  
S Mashima ◽  
K Hirota ◽  
T Hasegawa ◽  
...  
Keyword(s):  
Microsatellite Loci ◽  
Isolation And Characterization

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

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