scholarly journals Regulation and function of transaldolase isoenzymes involved in sugar and one-carbon metabolism in the ribulose monophosphate cycle methylotroph Arthrobacter P1

1986 ◽  
Vol 144 (2) ◽  
pp. 116-123 ◽  
Author(s):  
P. R. Levering ◽  
L. Dijkhuizen
Keyword(s):  
Carbon Metabolism ◽  
Arthrobacter P1 ◽  
Ribulose Monophosphate Cycle ◽  
One Carbon Metabolism ◽  
And Function

scholarly journals Isolation and characterization of mutants of the facultative methylotroph Arthrobacter P1 blocked in one-carbon metabolism

1987 ◽  
Vol 146 (4) ◽  
pp. 346-352 ◽  
Author(s):  
P. R. Levering ◽  
L. Tiesma ◽  
J. P. Woldendorp ◽  
M. Steensma ◽  
L. Dijkhuizen
Keyword(s):  
Carbon Metabolism ◽  
Arthrobacter P1 ◽  
Facultative Methylotroph ◽  
Isolation And Characterization ◽  
One Carbon Metabolism

scholarly journals Metabolism of Mycotoxins, Intracellular Functions of Vitamin B12, and Neurological Manifestations in Patients with Chronic Toxigenic Mold Exposures. A Review

2004 ◽  
Vol 4 ◽  
pp. 736-745 ◽  
Author(s):  
Ebere C. Anyanwu ◽  
Mohammed Morad ◽  
Andrew W. Campbell
Keyword(s):  
Carbon Metabolism ◽  
Synergistic Effects ◽  
Chromosome Breakage ◽  
Vitamin B ◽  
Neurological Manifestations ◽  
Ongoing Research ◽  
Normal Functions ◽  
One Carbon Metabolism ◽  
The One ◽  
And Function

This paper evaluates the possible reasons for consistent vitamin B12deficiency in chronic toxigenic mold exposures and the synergistic relationships with the possible mycotoxic effects on one-carbon metabolism that lead to the manifestations of clinical neuropathological symptomology. Vitamins are first defined in general and the nutritional sources of vitamin B12are evaluated in particular. Since patients with chronic exposures to toxigenic molds manifest vitamin B12deficiencies, the role of mycotoxins in vitamin B12metabolism is assessed, and since vitamin B12plays important biochemical roles in one-carbon metabolism, the synergistic effects with mycotoxins on humans are reviewed. An outline of the proposed mechanism by which mycotoxins disrupt or interfere with the normal functions of vitamin B12on one-carbon metabolism is proposed. The overall functions of vitamin B12as a source of coenzymes, in intracellular recycling of methionine, in methionine synthase reaction, in the prevention of chromosome breakage, in methylation, and in maintaining a one-carbon metabolic balance are reviewed. Signs, symptoms, and clinical neurological indications of vitamin B12deficiency are also cited. By implication and derivation, it is likely that the interruption of the structure and function of vitamin B12would in turn interfere with the one-carbon metabolism leading to the neurological manifestations. This review is an attempt to formulate a basis for an ongoing research investigation on the subject.

scholarly journals Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexander I. May ◽  
Mark Prescott ◽  
Yoshinori Ohsumi
Keyword(s):  
Protein Expression ◽  
Carbon Metabolism ◽  
Mitochondrial Protein ◽  
Physiological Role ◽  
Degradation Pathway ◽  
Trna Modification ◽  
Respiratory Growth ◽  
One Carbon Metabolism ◽  
And Function

AbstractThe mechanism and function of autophagy as a highly-conserved bulk degradation pathway are well studied, but the physiological role of autophagy remains poorly understood. We show that autophagy is involved in the adaptation of Saccharomyces cerevisiae to respiratory growth through its recycling of serine. On respiratory media, growth onset, mitochondrial initiator tRNA modification and mitochondrial protein expression are delayed in autophagy defective cells, suggesting that mitochondrial one-carbon metabolism is perturbed in these cells. The supplementation of serine, which is a key one-carbon metabolite, is able to restore mitochondrial protein expression and alleviate delayed respiratory growth. These results indicate that autophagy-derived serine feeds into mitochondrial one-carbon metabolism, supporting the initiation of mitochondrial protein synthesis and allowing rapid adaptation to respiratory growth.

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

scholarly journals Effect of a Tailored Dietary Intervention with High or Standard Protein Intake on B-Vitamin and One Carbon Metabolism Status in Healthy Older Males: A 10 Week Randomised Controlled Trial

Proceedings ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 19
Author(s):  
Nicola Gillies ◽  
Amber M. Milan ◽  
Pankaja Sharma ◽  
Brenan Durainayagam ◽  
Sarah M. Mitchell ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Carbon Metabolism ◽  
Protein Intake ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
One Carbon Metabolism ◽  
Randomised Controlled ◽  
B Vitamin ◽  
Standard Protein ◽  
Older Males

Background: Maintaining optimal status of folate and metabolically [...]

One carbon (metabolism) to rule T cell identity

2021 ◽  
Vol 21 (4) ◽  
pp. 206-206
Author(s):  
Felix Clemens Richter ◽  
Alexander J. Clarke
Keyword(s):  
T Cell ◽  
Carbon Metabolism ◽  
Cell Identity ◽  
One Carbon Metabolism

Nutrition, One-Carbon Metabolism and Arsenic Methylation

Toxicology ◽  
2021 ◽  
pp. 152803
Author(s):  
Ahlam Abuawad ◽  
Anne K. Bozack ◽  
Roheeni Saxena ◽  
Mary V. Gamble
Keyword(s):  
Carbon Metabolism ◽  
Arsenic Methylation ◽  
One Carbon Metabolism
Sign in / Sign up

Export Citation Format

Share Document