Age-dependence of bone material quality shown by the measurement of frequency of resonance in the ulna

1994 ◽  
Vol 54 (2) ◽  
pp. 96-100 ◽  
Author(s):  
P. Kann ◽  
S. Graeben ◽  
J. Beyer
Keyword(s):  
Age Dependence ◽  
Bone Material ◽  
Material Quality ◽  
Frequency Of Resonance

scholarly journals Warfarin-induced impairment of bone material quality in a patient undergoing maintenance hemodialysis

Medicine ◽  
2020 ◽  
Vol 99 (25) ◽  
pp. e20724
Author(s):  
Hiroki Ishii ◽  
Satoshi Kurihara ◽  
Keiji Hirai ◽  
Katsunori Yanai ◽  
Susumu Ookawara ◽  
...  
Keyword(s):  
Maintenance Hemodialysis ◽  
Bone Material ◽  
Material Quality

scholarly journals Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli

2007 ◽  
Vol 194 (1) ◽  
pp. 213-222 ◽  
Author(s):  
Toshihiro Sugiyama ◽  
Toshiaki Takaki ◽  
Kenya Sakanaka ◽  
Hiroki Sadamaru ◽  
Koji Mori ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Cortical Bone ◽  
Bone Structure ◽  
Biomechanical Properties ◽  
Mechanical Stimuli ◽  
Bone Material ◽  
Material Quality ◽  
Compensatory Adaptation ◽  
Jumping Exercise

Long-term warfarin use has been reported to increase fracture risk of rib and vertebra but not hip in elderly patients, but the mechanisms remain unknown. We hypothesized that warfarin would impair bone material quality but could not weaken bone strength under conditions with higher mechanical stimuli. To test this hypothesis, rats were randomized to vehicle or warfarin group at 4 weeks of age and subsequently weight matched into a sedentary or jumping exercise group at 12 weeks of age. At 6 months of age, osteocalcin content, bone mineral density (BMD), mineral size, material properties, morphological parameters, and biomechanical properties of cortical bones were evaluated. In order to seek evidence for a common mechanism of action, effects of nucleation rate of mineral crystals on their rigidity were also investigated using computer simulation. In humeral cortical bones, warfarin did not change BMD, but markedly decreased osteocalcin content, diminished mineral size, and impaired material hardness. Consistent with these results, our computer-simulation model showed that osteocalcin-induced delay of mineral crystal nucleation decreased mineral formation rate, increased mean and distribution of mineral sizes, and strengthened mineral rigidity. In tibial cortical bones, warfarin decreased material ultimate stress; however, under jumping exercise, warfarin increased cross-sectional total and bone areas of these tibiae and completely maintained their biomechanical properties including work to failure. Collectively, our findings suggest that long-term warfarin therapy weakens rib and vertebra by impairing cortical bone material quality due to a marked decrease in osteocalcin content but could not reduce hip strength through compensatory adaptation of cortical bone structure to higher mechanical stimuli.

Evidence of systemic deterioration of bone material quality in cases of osteochondrosis dissecans

Bone ◽  
2012 ◽  
Vol 51 (6) ◽  
pp. S19
Author(s):  
P. Messmer ◽  
G. Vekszler ◽  
P. Roschger ◽  
K. Klaushofer
Keyword(s):  
Osteochondrosis Dissecans ◽  
Bone Material ◽  
Material Quality

scholarly journals Severely Impaired Bone Material Quality in Chihuahua Zebrafish Resembles Classical Dominant Human Osteogenesis Imperfecta

2018 ◽  
Vol 33 (8) ◽  
pp. 1489-1499 ◽  
Author(s):  
Imke A.K. Fiedler ◽  
Felix N. Schmidt ◽  
Eva M. Wölfel ◽  
Christine Plumeyer ◽  
Petar Milovanovic ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Bone Material ◽  
Material Quality

Bone Material Quality

2017 ◽  
pp. 1-15 ◽  
Author(s):  
Paul Roschger ◽  
Stéphane Blouin ◽  
Eleftherios Paschalis ◽  
Sonja Gamsjaeger ◽  
Klaus Klaushofer ◽  
...  
Keyword(s):  
Bone Material ◽  
Material Quality

scholarly journals Bone Material Quality in Transiliac Bone Biopsies of Postmenopausal Osteoporotic Women After 3 Years Strontium Ranelate Treatment

2009 ◽  
pp. 091019190442039-35 ◽  
Author(s):  
Paul Roschger ◽  
I Manjubala ◽  
N Zoeger ◽  
F Meirer ◽  
R Simon ◽  
...  
Keyword(s):  
Strontium Ranelate ◽  
Bone Material ◽  
Material Quality ◽  
Bone Biopsies

scholarly journals Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae

2022 ◽  
Author(s):  
Takuya Ishimoto ◽  
Mitsuru Saito ◽  
Ryosuke Ozasa ◽  
Yoshihiro Matsumoto ◽  
Takayoshi Nakano
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Young’S Modulus ◽  
Young's Modulus ◽  
Estrogen Deficiency ◽  
Dependent Manner ◽  
Mineral Density ◽  
Bone Material ◽  
Material Quality ◽  
Mechanical Integrity

AbstractBone material quality is important for evaluating the mechanical integrity of diseased and/or medically treated bones. However, compared to the knowledge accumulated regarding changes in bone mass, our understanding of the quality of bone material is lacking. In this study, we clarified the changes in bone material quality mainly characterized by the preferential orientation of the apatite c-axis associated with estrogen deficiency-induced osteoporosis, and their prevention using ibandronate (IBN), a nitrogen-containing bisphosphonate. IBN effectively prevented bone loss and degradation of whole bone strength in a dose-dependent manner. The estrogen-deficient condition abnormally increased the degree of apatite orientation along the craniocaudal axis in which principal stress is applied; IBN at higher doses played a role in maintaining the normal orientation of apatite but not at lower doses. The bone size-independent Young's modulus along the craniocaudal axis of the anterior cortical shell of the vertebra showed a significant and positive correlation with apatite orientation; therefore, the craniocaudal Young’s modulus abnormally increased under estrogen-deficient conditions, despite a significant decrease in volumetric bone mineral density. However, the abnormal increase in craniocaudal Young's modulus did not compensate for the degradation of whole bone mechanical properties due to the bone loss. In conclusion, it was clarified that changes in the material quality, which are hidden in bone mass evaluation, occur with estrogen deficiency-induced osteoporosis and IBN treatment. Here, IBN was shown to be a beneficial drug that suppresses abnormal changes in bone mechanical integrity caused by estrogen deficiency at both the whole bone and material levels.

scholarly journals Impact of tenofovir disoproxil‐induced Fanconi Syndrome on bone material quality: a case report

JBMR Plus ◽  
2021 ◽  
Author(s):  
Benjamin Hadzimuratovic ◽  
Judith Haschka ◽  
Markus A. Hartmann ◽  
Stéphane Blouin ◽  
Nadja Fratzl‐Zelman ◽  
...  
Keyword(s):  
Case Report ◽  
Fanconi Syndrome ◽  
Bone Material ◽  
Material Quality

scholarly journals Bone Organic-Inorganic Phase Ratio Is a Fundamental Determinant of Bone Material Quality

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yunhua Luo ◽  
Ogheneriobororue Amromanoh
Keyword(s):  
Mechanical Properties ◽  
Peak Stress ◽  
Bone Diseases ◽  
Phase Ratio ◽  
Statistical Characteristics ◽  
Mineral Density ◽  
Bone Material ◽  
Material Quality ◽  
Manufacturing Method ◽  
Optimal Ratio

Background. Bone mineral density is widely used by clinicians for screening osteoporosis and assessing bone strength. However, its effectiveness has been reported unsatisfactory. In this study, it is demonstrated that bone organic-inorganic phase ratio is a fundamental determinant of bone material quality measured by stiffness, strength, and toughness. Methods and Results. Two-hundred standard bone specimens were fabricated from bovine legs, with a specialized manufacturing method that was designed to reduce the effect of bone anisotropy. Bone mechanical properties of the specimens, including Young’s modulus, yield stress, peak stress, and energy-to-failure, were measured by mechanical testing. Organic and inorganic mass contents of the specimens were then determined by bone ashing. Bone density and organic-inorganic phase ratio in the specimens were calculated. Statistical methods were applied to study relationships between the measured mechanical properties and the organic-inorganic phase ratios. Statistical characteristics of organic-inorganic phase ratios in the specimens with top material quality were investigated. Bone organic-inorganic phase ratio had strong Spearman correlation with bone material properties. Bone specimens that had the highest material quality had a very narrow scope of organic-inorganic phase ratio, which could be considered as the “optimal” ratio among the tested specimens. Conclusion. Bone organic-inorganic phase ratio is a fundamental determinant of bone material quality. There may exist an “optimal” ratio for the bone to achieve top material quality. Deviation from the “optimal” ratio is probably the fundamental cause of various bone diseases. This study suggests that bone organic-inorganic phase ratio should be considered in clinical assessment of fracture risk.

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