scholarly journals Severely Impaired Bone Material Quality in Chihuahua Zebrafish Resembles Classical Dominant Human Osteogenesis Imperfecta

2018 ◽  
Vol 33 (8) ◽  
pp. 1489-1499 ◽  
Author(s):  
Imke A.K. Fiedler ◽  
Felix N. Schmidt ◽  
Eva M. Wölfel ◽  
Christine Plumeyer ◽  
Petar Milovanovic ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Bone Material ◽  
Material Quality

Skeletal and bone material phenotype in recessive osteogenesis imperfecta due to a novel homozygous point mutation in TMEM38B

2015 ◽  
Author(s):  
Emma Webb ◽  
Meena Balasubramanian ◽  
Trevor Cole ◽  
Sue Stewart ◽  
Nicola Crabtree ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Point Mutation ◽  
Bone Material

scholarly journals Warfarin-induced impairment of bone material quality in a patient undergoing maintenance hemodialysis

Medicine ◽  
2020 ◽  
Vol 99 (25) ◽  
pp. e20724
Author(s):  
Hiroki Ishii ◽  
Satoshi Kurihara ◽  
Keiji Hirai ◽  
Katsunori Yanai ◽  
Susumu Ookawara ◽  
...  
Keyword(s):  
Maintenance Hemodialysis ◽  
Bone Material ◽  
Material Quality

scholarly journals Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli

2007 ◽  
Vol 194 (1) ◽  
pp. 213-222 ◽  
Author(s):  
Toshihiro Sugiyama ◽  
Toshiaki Takaki ◽  
Kenya Sakanaka ◽  
Hiroki Sadamaru ◽  
Koji Mori ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Cortical Bone ◽  
Bone Structure ◽  
Biomechanical Properties ◽  
Mechanical Stimuli ◽  
Bone Material ◽  
Material Quality ◽  
Compensatory Adaptation ◽  
Jumping Exercise

Long-term warfarin use has been reported to increase fracture risk of rib and vertebra but not hip in elderly patients, but the mechanisms remain unknown. We hypothesized that warfarin would impair bone material quality but could not weaken bone strength under conditions with higher mechanical stimuli. To test this hypothesis, rats were randomized to vehicle or warfarin group at 4 weeks of age and subsequently weight matched into a sedentary or jumping exercise group at 12 weeks of age. At 6 months of age, osteocalcin content, bone mineral density (BMD), mineral size, material properties, morphological parameters, and biomechanical properties of cortical bones were evaluated. In order to seek evidence for a common mechanism of action, effects of nucleation rate of mineral crystals on their rigidity were also investigated using computer simulation. In humeral cortical bones, warfarin did not change BMD, but markedly decreased osteocalcin content, diminished mineral size, and impaired material hardness. Consistent with these results, our computer-simulation model showed that osteocalcin-induced delay of mineral crystal nucleation decreased mineral formation rate, increased mean and distribution of mineral sizes, and strengthened mineral rigidity. In tibial cortical bones, warfarin decreased material ultimate stress; however, under jumping exercise, warfarin increased cross-sectional total and bone areas of these tibiae and completely maintained their biomechanical properties including work to failure. Collectively, our findings suggest that long-term warfarin therapy weakens rib and vertebra by impairing cortical bone material quality due to a marked decrease in osteocalcin content but could not reduce hip strength through compensatory adaptation of cortical bone structure to higher mechanical stimuli.

Evidence of systemic deterioration of bone material quality in cases of osteochondrosis dissecans

Bone ◽  
2012 ◽  
Vol 51 (6) ◽  
pp. S19
Author(s):  
P. Messmer ◽  
G. Vekszler ◽  
P. Roschger ◽  
K. Klaushofer
Keyword(s):  
Osteochondrosis Dissecans ◽  
Bone Material ◽  
Material Quality

Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)

Bone ◽  
2001 ◽  
Vol 29 (5) ◽  
pp. 453-457 ◽  
Author(s):  
B Grabner ◽  
W.J Landis ◽  
P Roschger ◽  
S Rinnerthaler ◽  
H Peterlik ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Murine Model ◽  
Material Properties ◽  
Bone Material ◽  
Bone Material Properties

Bone Material Quality

2017 ◽  
pp. 1-15 ◽  
Author(s):  
Paul Roschger ◽  
Stéphane Blouin ◽  
Eleftherios Paschalis ◽  
Sonja Gamsjaeger ◽  
Klaus Klaushofer ◽  
...  
Keyword(s):  
Bone Material ◽  
Material Quality

scholarly journals Macroscopic anisotropic bone material properties in children with severe osteogenesis imperfecta

2017 ◽  
Vol 64 ◽  
pp. 103-111 ◽  
Author(s):  
Carolyne Albert ◽  
John Jameson ◽  
Sergey Tarima ◽  
Peter Smith ◽  
Gerald Harris
Keyword(s):  
Osteogenesis Imperfecta ◽  
Material Properties ◽  
Bone Material ◽  
Bone Material Properties

scholarly journals Bone Material Quality in Transiliac Bone Biopsies of Postmenopausal Osteoporotic Women After 3 Years Strontium Ranelate Treatment

2009 ◽  
pp. 091019190442039-35 ◽  
Author(s):  
Paul Roschger ◽  
I Manjubala ◽  
N Zoeger ◽  
F Meirer ◽  
R Simon ◽  
...  
Keyword(s):  
Strontium Ranelate ◽  
Bone Material ◽  
Material Quality ◽  
Bone Biopsies
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