Differential impact of changes in cortical bone material quality and diaphyseal design on the bone strength index (BSI) calculation in normal men and pre- or post-menopausal women

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S177
Author(s):  
P. Reina ◽  
J.L. Ferretti⁎ ◽  
G.R. Cointry ◽  
S. Feldman ◽  
R. Capozza
Keyword(s):  
Cortical Bone ◽  
Bone Strength ◽  
Strength Index ◽  
Differential Impact ◽  
Bone Material ◽  
Material Quality ◽  
Bone Strength Index ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Normal Men

Correlation of pQCT bone strength index with mechanical testing in distraction osteogenesis

Bone ◽  
2009 ◽  
Vol 45 (3) ◽  
pp. 512-516 ◽  
Author(s):  
Constantinos Kokoroghiannis ◽  
Ioannis Charopoulos ◽  
Georgios Lyritis ◽  
Panagiota Raptou ◽  
Theofilos Karachalios ◽  
...  
Keyword(s):  
Mechanical Testing ◽  
Bone Strength ◽  
Distraction Osteogenesis ◽  
Strength Index ◽  
Bone Strength Index

scholarly journals Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli

2007 ◽  
Vol 194 (1) ◽  
pp. 213-222 ◽  
Author(s):  
Toshihiro Sugiyama ◽  
Toshiaki Takaki ◽  
Kenya Sakanaka ◽  
Hiroki Sadamaru ◽  
Koji Mori ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Cortical Bone ◽  
Bone Structure ◽  
Biomechanical Properties ◽  
Mechanical Stimuli ◽  
Bone Material ◽  
Material Quality ◽  
Compensatory Adaptation ◽  
Jumping Exercise

Long-term warfarin use has been reported to increase fracture risk of rib and vertebra but not hip in elderly patients, but the mechanisms remain unknown. We hypothesized that warfarin would impair bone material quality but could not weaken bone strength under conditions with higher mechanical stimuli. To test this hypothesis, rats were randomized to vehicle or warfarin group at 4 weeks of age and subsequently weight matched into a sedentary or jumping exercise group at 12 weeks of age. At 6 months of age, osteocalcin content, bone mineral density (BMD), mineral size, material properties, morphological parameters, and biomechanical properties of cortical bones were evaluated. In order to seek evidence for a common mechanism of action, effects of nucleation rate of mineral crystals on their rigidity were also investigated using computer simulation. In humeral cortical bones, warfarin did not change BMD, but markedly decreased osteocalcin content, diminished mineral size, and impaired material hardness. Consistent with these results, our computer-simulation model showed that osteocalcin-induced delay of mineral crystal nucleation decreased mineral formation rate, increased mean and distribution of mineral sizes, and strengthened mineral rigidity. In tibial cortical bones, warfarin decreased material ultimate stress; however, under jumping exercise, warfarin increased cross-sectional total and bone areas of these tibiae and completely maintained their biomechanical properties including work to failure. Collectively, our findings suggest that long-term warfarin therapy weakens rib and vertebra by impairing cortical bone material quality due to a marked decrease in osteocalcin content but could not reduce hip strength through compensatory adaptation of cortical bone structure to higher mechanical stimuli.

scholarly journals Correlation of ADIPOQ Gene Single Nucleotide Polymorphisms with Bone Strength Index in Middle-Aged and the Elderly of Guangxi Mulam Ethnic Group

2021 ◽  
Vol 18 (24) ◽  
pp. 13034
Author(s):  
Min Zhou ◽  
Ning Ning ◽  
Yueming Jiang ◽  
Michael Aschner ◽  
Xiufeng Huang ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Strength ◽  
Susceptibility Gene ◽  
Subcutaneous Fat ◽  
The Elderly ◽  
Strength Index ◽  
Middle Aged ◽  
Single Nucleotide ◽  
Adipoq Gene ◽  
Bone Strength Index

Background: Osteoporosis (OP) is a common orthopedic disease in the elderly, and Adiponectin (ADIPOQ) is closely related to bone metabolism. Objective: To determine the relationship between five single nucleotide polymorphism (SNP) loci in the ADIPOQ gene and osteoporosis in middle-aged and elderly Mulam subjects in Hechi, Guangxi. Methods: This case-control study included 297 middle-aged and elderly Mulam subjects with normal bone mass, 49 subjects with reduced bone mass, and 38 subjects with osteoporosis. Five loci (rs266729, rs1063539, rs2241766, rs3774261, rs710445) of the ADIPOQ in the Mulam subjects were genotyped using SNP with multiple-base extension. Results: The bone strength index (SI) of middle-aged and elderly Mulam subjects showed an overall decreasing trend when the subjects were older. Age, muscle mass, and subcutaneous fat content were the main factors influencing the SI in Mulam subjects. The GC genotype of rs266729 and the GA and GG genotypes of rs710445 were significantly correlated with risk of bone loss (p < 0.05). rs2241766 and rs1063539 showed strong LD (D’ > 0.8, r2 > 0.33). rs710445 and rs266729 loci and rs3774261 and rs2241766 loci showed complete LD (D’ = 1). Conclusions: The GC genotype at rs266729 of the ADIPOQ gene, the GA and GG genotypes at rs710445, and the haplotypes CCGAA and GGTAG correlated with osteoporosis (p < 0.05). The allele C of rs1063539, rs266729 and rs710445 may afford protection for osteoporosis. The allele G may be the genetic susceptibility gene for osteoporosis, increasing the risk of osteoporosis.

CORRELATIONS BETWEEN MAXIMAL MUSCLE-FORCE/-TORQUE AND A BONE STRENGTH INDEX IN UPPER LIMBS

1998 ◽  
Vol 30 (Supplement) ◽  
pp. 290
Author(s):  
M. Hartard ◽  
H. Schiessl ◽  
P. Bartenstein ◽  
Th. Hilberg ◽  
D. Jeschke
Keyword(s):  
Bone Strength ◽  
Muscle Force ◽  
Upper Limbs ◽  
Strength Index ◽  
Bone Strength Index

scholarly journals Bone material strength index as measured by impact microindentation is altered in patients with acromegaly

2017 ◽  
Vol 176 (3) ◽  
pp. 339-347 ◽  
Author(s):  
F Malgo ◽  
N A T Hamdy ◽  
T J Rabelink ◽  
H M Kroon ◽  
K M J A Claessen ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Tissue Level ◽  
Material Strength ◽  
Strength Index ◽  
Mineral Density ◽  
Cross Sectional ◽  
Bone Material ◽  
Normal Bone Mineral Density ◽  
Bone Material Strength ◽  
Impact Microindentation

Objective Acromegaly is a rare disease caused by excess growth hormone (GH) production by the pituitary adenoma. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of relatively normal bone mineral density (BMD). We aimed to evaluate tissue-level properties of bone using impact microindentation (IMI) in well-controlled patients with acromegaly aged ≥18 years compared to 44 controls from the outpatient clinic of the Centre for Bone Quality. Design and methods In this cross-sectional study, bone material strength index (BMSi) was measured in 48 acromegaly patients and 44 controls with impact microindentation using the osteoprobe. Results Mean age of acromegaly patients (54% male) was 60.2 years (range 37.9–76.5), and 60.5 years (range 39.8–78.6) in controls (50% male). Patients with acromegaly and control patients had comparable BMI (28.2 kg/m2 ± 4.7 vs 26.6 kg/m2 ± 4.3, P = 0.087) and comparable BMD at the lumbar spine (1.04 g/cm2 ± 0.21 vs 1.03 g/cm2 ± 0.13, P = 0.850) and at the femoral neck (0.84 g/cm2 ± 0.16 vs 0.80 g/cm2 ± 0.09, P = 0.246). BMSi was significantly lower in acromegaly patients than that in controls (79.4 ± 0.7 vs 83.2 ± 0.7; P < 0.001). Conclusion Our data indicates that tissue-level properties of cortical bone are significantly altered in patients with controlled acromegaly after reversal of long-term exposure to pathologically high GH and IGF-1 levels. Our findings also suggest that methods other than DXA should be considered to evaluate bone fragility in patients with acromegaly.

scholarly journals Sarcopenic obesity worsens bone strength: hip strength analysis in post-menopausal women

2014 ◽  
Author(s):  
Antimo Moretti ◽  
Maria Teresa Giamattei ◽  
Sire Alessandro de ◽  
Giovanni Cannaviello ◽  
Francesca Gimigliano ◽  
...  
Keyword(s):  
Bone Strength ◽  
Sarcopenic Obesity ◽  
Strength Analysis ◽  
Hip Strength ◽  
Menopausal Women ◽  
Post Menopausal
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