scholarly journals Impact of tenofovir disoproxil‐induced Fanconi Syndrome on bone material quality: a case report

JBMR Plus ◽  
2021 ◽  
Author(s):  
Benjamin Hadzimuratovic ◽  
Judith Haschka ◽  
Markus A. Hartmann ◽  
Stéphane Blouin ◽  
Nadja Fratzl‐Zelman ◽  
...  
Keyword(s):  
Case Report ◽  
Fanconi Syndrome ◽  
Bone Material ◽  
Material Quality

scholarly journals TINU-associated Fanconi syndrome: a case report and review of literature

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Bernard Vô ◽  
Jean Cyr Yombi ◽  
Selda Aydin ◽  
Nathalie Demoulin ◽  
Halil Yildiz
Keyword(s):  
Case Report ◽  
Fanconi Syndrome ◽  
Review Of Literature

scholarly journals Wissler-Fanconi syndrome and related diagnoses: a case report

2016 ◽  
Vol Volume 8 ◽  
pp. 73-75
Author(s):  
M Albustani ◽  
Robert Howard
Keyword(s):  
Case Report ◽  
Fanconi Syndrome

Severe Hypophosphatemic Osteomalacia Secondary to Fanconi Syndrome Due to Adefovir: A Case Report

2014 ◽  
Vol 20 (12) ◽  
pp. e246-e249 ◽  
Author(s):  
Andrea Palermo ◽  
Rocky Strollo ◽  
Rocco Papalia ◽  
Luca D’Onofrio ◽  
Ernesto Maddaloni ◽  
...  
Keyword(s):  
Case Report ◽  
Fanconi Syndrome ◽  
Hypophosphatemic Osteomalacia

scholarly journals Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Qian Xiang ◽  
Zhiyan Liu ◽  
Yanyan Yu ◽  
Hanxu Zhang ◽  
Qiufen Xie ◽  
...  
Keyword(s):  
Renal Failure ◽  
Case Report ◽  
Adefovir Dipivoxil ◽  
Fanconi Syndrome ◽  
Low Dose

scholarly journals Warfarin-induced impairment of bone material quality in a patient undergoing maintenance hemodialysis

Medicine ◽  
2020 ◽  
Vol 99 (25) ◽  
pp. e20724
Author(s):  
Hiroki Ishii ◽  
Satoshi Kurihara ◽  
Keiji Hirai ◽  
Katsunori Yanai ◽  
Susumu Ookawara ◽  
...  
Keyword(s):  
Maintenance Hemodialysis ◽  
Bone Material ◽  
Material Quality

scholarly journals De Toni-Debré-Fanconi syndrome in a patient with Kearns-Sayre syndrome: a case report

2009 ◽  
Vol 3 (1) ◽  
Author(s):  
Cristina Maria Mihai ◽  
Doina Catrinoiu ◽  
Marius Toringhibel ◽  
Ramona Mihaela Stoicescu ◽  
Anca Hancu
Keyword(s):  
Case Report ◽  
Fanconi Syndrome ◽  
Kearns Sayre Syndrome

scholarly journals Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli

2007 ◽  
Vol 194 (1) ◽  
pp. 213-222 ◽  
Author(s):  
Toshihiro Sugiyama ◽  
Toshiaki Takaki ◽  
Kenya Sakanaka ◽  
Hiroki Sadamaru ◽  
Koji Mori ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Cortical Bone ◽  
Bone Structure ◽  
Biomechanical Properties ◽  
Mechanical Stimuli ◽  
Bone Material ◽  
Material Quality ◽  
Compensatory Adaptation ◽  
Jumping Exercise

Long-term warfarin use has been reported to increase fracture risk of rib and vertebra but not hip in elderly patients, but the mechanisms remain unknown. We hypothesized that warfarin would impair bone material quality but could not weaken bone strength under conditions with higher mechanical stimuli. To test this hypothesis, rats were randomized to vehicle or warfarin group at 4 weeks of age and subsequently weight matched into a sedentary or jumping exercise group at 12 weeks of age. At 6 months of age, osteocalcin content, bone mineral density (BMD), mineral size, material properties, morphological parameters, and biomechanical properties of cortical bones were evaluated. In order to seek evidence for a common mechanism of action, effects of nucleation rate of mineral crystals on their rigidity were also investigated using computer simulation. In humeral cortical bones, warfarin did not change BMD, but markedly decreased osteocalcin content, diminished mineral size, and impaired material hardness. Consistent with these results, our computer-simulation model showed that osteocalcin-induced delay of mineral crystal nucleation decreased mineral formation rate, increased mean and distribution of mineral sizes, and strengthened mineral rigidity. In tibial cortical bones, warfarin decreased material ultimate stress; however, under jumping exercise, warfarin increased cross-sectional total and bone areas of these tibiae and completely maintained their biomechanical properties including work to failure. Collectively, our findings suggest that long-term warfarin therapy weakens rib and vertebra by impairing cortical bone material quality due to a marked decrease in osteocalcin content but could not reduce hip strength through compensatory adaptation of cortical bone structure to higher mechanical stimuli.

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