Requirement of the human chromosome 11 long arm for replication of herpes simplex virus type 1 in nonpermissive Chinese hamster x human diploid fibroblast hybrids

1982 ◽  
Vol 7 (2) ◽  
pp. 171-191 ◽  
Author(s):  
Uta Francke ◽  
Bertold Francke
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Human Chromosome ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Chinese Hamster ◽  
Chromosome 11 ◽  
Human Diploid Fibroblast ◽  
Simplex Virus

scholarly journals Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells

2007 ◽  
Vol 88 (4) ◽  
pp. 1075-1079 ◽  
Author(s):  
Vaibhav Tiwari ◽  
Christopher O'Donnell ◽  
Ronald J. Copeland ◽  
Tanya Scarlett ◽  
Jian Liu ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Heparan Sulfate ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus type 1 (HSV-1) interaction with glycoprotein D (gD) receptors facilitates virus entry into cells. Chinese hamster ovary (CHO-K1) cells lacking cellular receptors allow virus to attach, but not to enter, implying a role for receptors during the post-attachment (entry) phase of HSV-1 infection. Here, it is shown that the presence of soluble heparan sulfate (HS) modified by 3-O-sulfotransferase-3 (3-OST-3), but not by 3-OST-1, triggered HSV-1 entry into resistant CHO-K1 cells. It was further demonstrated that a CHO-K1 mutant deficient in glycosaminoglycan synthesis became susceptible to entry when spinoculated in the presence of 3-OST-3-modified soluble HS, indicating that the role of the gD receptor is to trigger entry rather than cell attachment. In separate experiments, 3-OST-3-modified soluble HS also triggered fusion of HSV-1 glycoprotein-expressing cells with CHO-K1 cells. Taken together, these results show that association of gD with cell surface-bound receptor is not essential for HSV-1 entry and spread.

Role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peptic Ulcer Disease ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Ulcer Disease ◽  
Simplex Virus
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