Sex differences in the sensitivity of CBA mice to convulsions induced by GABA antagonists are age-dependent

1987 ◽  
Vol 91 (2) ◽  
pp. 226-229 ◽  
Author(s):  
Hari Manev ◽  
Danka Peričić ◽  
Suzana Anić-Stojiljković
Hypertension ◽  
2019 ◽  
Vol 74 (Suppl_1) ◽  
Author(s):  
Franco J Puleo ◽  
Alissa A Frame ◽  
Parul Chaudhary ◽  
Richard D Wainford

2004 ◽  
Vol 192 (1-2) ◽  
pp. 83-89 ◽  
Author(s):  
Patricia Guimaraes ◽  
Xiaoxia Zhu ◽  
Trinitia Cannon ◽  
SungHee Kim ◽  
Robert D. Frisina

2011 ◽  
Vol 21 (3) ◽  
pp. 244-252 ◽  
Author(s):  
Liljana Mervic ◽  
Ulrike Leiter ◽  
Friedegund Meier ◽  
Thomas Eigentler ◽  
Andrea Forschner ◽  
...  

2015 ◽  
Vol 28 (5) ◽  
pp. 1067-1079 ◽  
Author(s):  
T. M. Houslay ◽  
J. Hunt ◽  
M. C. Tinsley ◽  
L. F. Bussière

2016 ◽  
Vol 46 ◽  
pp. 11-17 ◽  
Author(s):  
Yoshiyuki Kobayashi ◽  
Hiroaki Hobara ◽  
Thijs A. Heldoorn ◽  
Makiko Kouchi ◽  
Masaaki Mochimaru

1979 ◽  
Vol 149 (6) ◽  
pp. 1519-1530 ◽  
Author(s):  
JL Van Snick ◽  
PL Masson

Although much of the basic immunological work has been done with mice, little is known about anti-IgG autoantibodies in this species. Dresser (1, 2) has reported the occurrence, in CBA mice, of anti-IgG antibody (Ab)(1) detected by a hemolytic-plaque assay after stimulation with endotoxin or immunization against sheep erythrocytes. IgM rheumatoid factor has also been described in various strains of mice with a systemic lupus erythematosus-like disease (3). Recently, we have tried to induce anti-IgG in mice of the 129/Sv strain by inoculating autologous IgG. To our surprise, we found that the sera of all the animals had, before any inoculation, anti-IgG detectable by agglutination of particles coated with autologous IgG. The possibilities to investigate the mechanism of production and the biological role of this kind of Ab prompted us to undertake a study of the nature and specificity of the mouse anti-IgG.


2002 ◽  
Vol 14 (6) ◽  
pp. 693-698 ◽  
Author(s):  
Zygmunt Welon ◽  
Alicja Szklarska ◽  
Tadeusz Bielicki ◽  
Robert M. Malina

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi255-vi255
Author(s):  
Gina Rhee ◽  
Lauren Broestl ◽  
Lucia Grandison ◽  
Nicole Warrington ◽  
Najla Kfoury ◽  
...  

Abstract Sex differences in the rates of glioblastoma increase with age. There are likely to be multiple biological mechanisms underlying these sex differences. Here, we focused on the changes that occur with aging in the secretomes of male and female astrocytes to determine whether sex differences in chemokine and cytokine secretion, and inflammatory cell recruitment, could be one of those mechanisms. We focused on glioblastoma (GBM) and the role that senescent astrocytes might play in the age-dependent widening of the gap between male and female GBM cases. We found that the senescence associated secretory phenotype of male and female astrocytes significantly differed, notably in the enrichment of Fractalkine (1.33:1 (F:M)), the primary chemoattractant for microglia, in female compared to male SASP. This was in contrast to the greater abundance of tumorigenic growth factors like bFGF (1.25:1 (M:F)), in the male SASP. Implantation of either male or female senescent astrocytes into the brains of mice resulted in the recruitment of microglia to the injection site. Regardless of the recipient mouse sex, female astrocyte implantation resulted in significantly larger microglial infiltrates (2-fold) and greater astrocyte activation, as compared to the injection of equal numbers of male senescent cells. We propose a model for how sex differences in astrocyte SASP could result in lower rates of GBM with age in females: greater microglial attraction to senescent cells results in their enhanced clearance and consequently a reduction in senescence-associated GBM promotion.


Cortex ◽  
2013 ◽  
Vol 49 (7) ◽  
pp. 1910-1921 ◽  
Author(s):  
Marco Hirnstein ◽  
René Westerhausen ◽  
Maria S. Korsnes ◽  
Kenneth Hugdahl

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