Minimal Radius of Curvature of Lipid Bilayers in the Gel Phase State Corresponds to the Dimension of Biomembrane Structures “Caveolae”

1998 ◽  
Vol 124 (1) ◽  
pp. 77-87 ◽  
Author(s):  
Helmut W. Meyer ◽  
Martin Westermann ◽  
Matthias Stumpf ◽  
Walter Richter ◽  
Anne S. Ulrich ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Phase State ◽  
Radius Of Curvature ◽  
Minimal Radius ◽  
Gel Phase

scholarly journals The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 117 ◽  
Author(s):  
Ramsia Geisler ◽  
Carina Dargel ◽  
Thomas Hellweg
Keyword(s):  
Lipid Bilayers ◽  
Lipid Membranes ◽  
Phase State ◽  
Chemical Properties ◽  
Langmuir Monolayers ◽  
Model Membranes ◽  
Biologically Active ◽  
Horse Chestnut ◽  
Lipid Phase ◽  
Gel Phase

This review discusses recent progress in physicochemical understanding of the action of the saponin β -aescin (also called β -escin), the biologically active component in the seeds of the horse chestnut tree Aesculus hippocastanum. β -Aescin is used in pharmacological and cosmetic applications showing strong surface activity. In this review, we outline the most important findings describing the behavior of β -aescin in solution (e.g., critical micelle concentration ( c m c ) and micelle shape) and special physicochemical properties of adsorbed β -aescin monolayers at the air–water and oil–water interface. Such monolayers were found to posses very special viscoelastic properties. The presentation of the experimental findings is complemented by discussing recent molecular dynamics simulations. These simulations do not only quantify the predominant interactions in adsorbed monolayers but also highlight the different behavior of neutral and ionized β -aescin molecules. The review concludes on the interaction of β -aescin with phospholipid model membranes in the form of bilayers and Langmuir monolayers. The interaction of β -aescin with lipid bilayers was found to strongly depend on its c m c . At concentrations below the c m c , membrane parameters are modified whereas above the c m c , complete solubilization of the bilayers occurs, depending on lipid phase state and concentration. In the presence of gel-phase phospholipids, discoidal bicelles form; these are tunable in size by composition. The phase behavior of β -aescin with lipid membranes can also be modified by addition of other molecules such as cholesterol or drug molecules. The lipid phase state also determines the penetration rate of β -aescin molecules into lipid monolayers. The strongest interaction was always found in the presence of gel-phase phospholipid molecules.

Fluid or gel phase lipid bilayers to study peptide-membrane interactions?

1996 ◽  
Vol 25 (1) ◽  
pp. 55-59 ◽  
Author(s):  
T. Pott ◽  
J. Dufourcq ◽  
E. J. Dufourc
Keyword(s):  
Lipid Bilayers ◽  
Membrane Interactions ◽  
Gel Phase

scholarly journals Variation of thermal conductivity of DPPC lipid bilayer membranes around the phase transition temperature

2017 ◽  
Vol 14 (130) ◽  
pp. 20170127 ◽  
Author(s):  
Sina Youssefian ◽  
Nima Rahbar ◽  
Christopher R. Lambert ◽  
Steven Van Dessel
Keyword(s):  
Phase Transition ◽  
Thermal Conductivity ◽  
Thermal Properties ◽  
Transition Temperature ◽  
Lipid Bilayer ◽  
Lipid Bilayers ◽  
Phase Transition Temperature ◽  
Temperature Gradients ◽  
Phase Behaviour ◽  
Gel Phase

Given their amphiphilic nature and chemical structure, phospholipids exhibit a strong thermotropic and lyotropic phase behaviour in an aqueous environment. Around the phase transition temperature, phospholipids transform from a gel-like state to a fluid crystalline structure. In this transition, many key characteristics of the lipid bilayers such as structure and thermal properties alter. In this study, we employed atomistic simulation techniques to study the structure and underlying mechanisms of heat transfer in dipalmitoylphosphatidylcholine (DPPC) lipid bilayers around the fluid–gel phase transformation. To investigate this phenomenon, we performed non-equilibrium molecular dynamics simulations for a range of different temperature gradients. The results show that the thermal properties of the DPPC bilayer are highly dependent on the temperature gradient. Higher temperature gradients cause an increase in the thermal conductivity of the DPPC lipid bilayer. We also found that the thermal conductivity of DPPC is lowest at the transition temperature whereby one lipid leaflet is in the gel phase and the other is in the liquid crystalline phase. This is essentially related to a growth in thermal resistance between the two leaflets of lipid at the transition temperature. These results provide significant new insights into developing new thermal insulation for engineering applications.

scholarly journals Structural Correlations and Thermodynamics of the Gel Phase in Lipid Bilayers

2012 ◽  
Vol 102 (3) ◽  
pp. 503a
Author(s):  
Richard O. Tjörnhammar ◽  
Olle Edholm
Keyword(s):  
Lipid Bilayers ◽  
Gel Phase

scholarly journals Preferential accumulation of Aβ(1−42) on gel phase domains of lipid bilayers: An AFM and fluorescence study

2007 ◽  
Vol 1768 (1) ◽  
pp. 146-154 ◽  
Author(s):  
A. Choucair ◽  
M. Chakrapani ◽  
B. Chakravarthy ◽  
J. Katsaras ◽  
L.J. Johnston
Keyword(s):  
Lipid Bilayers ◽  
Fluorescence Study ◽  
Preferential Accumulation ◽  
Gel Phase

scholarly journals Lipid Bilayers in the Gel Phase Become Saturated by Triton X-100 at Lower Surfactant Concentrations Than Those in the Fluid Phase

2012 ◽  
Vol 102 (11) ◽  
pp. 2510-2516 ◽  
Author(s):  
Hasna Ahyayauch ◽  
M. Isabel Collado ◽  
Alicia Alonso ◽  
Felix M. Goñi
Keyword(s):  
Lipid Bilayers ◽  
Fluid Phase ◽  
Gel Phase ◽  
Triton X

Fish Antifreeze Glycoproteins Protect Cellular Membranes During Lipid-Phase Transitions

Physiology ◽  
1997 ◽  
Vol 12 (4) ◽  
pp. 189-194
Author(s):  
LM Hays ◽  
RE Feeney ◽  
F Tablin ◽  
AE Oliver ◽  
NJ Walker ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Liquid Crystalline ◽  
Antarctic Fish ◽  
Cell Types ◽  
Lipid Phase ◽  
Crystal Formation ◽  
Ice Crystal ◽  
Antifreeze Glycoproteins ◽  
Lipid Phase Transitions ◽  
Gel Phase

Antifreeze proteins from Antarctic fish depress solution freezing temperatures, inhibit ice crystal formation, and prevent recrystallization on rewarming. They have been used to enhance survival of some cell types during hypothermic storage. The mechanism of their protection is thought to be important during the transition of lipid bilayers from a liquid crystalline to a gel phase.

Giant Vesicles and Their Use in Assays for Assessing Membrane Phase State, Curvature, Mechanics, and Electrical Properties

2019 ◽  
Vol 48 (1) ◽  
pp. 93-119 ◽  
Author(s):  
Rumiana Dimova
Keyword(s):  
Electrical Properties ◽  
Lipid Bilayers ◽  
Material Properties ◽  
Phase State ◽  
External Factors ◽  
Membrane Composition ◽  
Membrane Phase ◽  
Membrane Systems ◽  
Giant Vesicles ◽  
Vesicle Preparation

Giant unilamellar vesicles represent a promising and extremely useful model biomembrane system for systematic measurements of mechanical, thermodynamic, electrical, and rheological properties of lipid bilayers as a function of membrane composition, surrounding media, and temperature. The most important advantage of giant vesicles over other model membrane systems is that the membrane responses to external factors such as ions, (macro)molecules, hydrodynamic flows, or electromagnetic fields can be directly observed under the microscope. Here, we briefly review approaches for giant vesicle preparation and describe several assays used for deducing the membrane phase state and measuring a number of material properties, with further emphasis on membrane reshaping and curvature.

Effect of intra-membrane C60 fullerenes on the modulus of elasticity and the mechanical resistance of gel and fluid lipid bilayers

Nanoscale ◽  
2015 ◽  
Vol 7 (40) ◽  
pp. 17102-17108 ◽  
Author(s):  
Jihan Zhou ◽  
Dehai Liang ◽  
Sonia Contera
Keyword(s):  
Light Scattering ◽  
Lipid Bilayers ◽  
Modulus Of Elasticity ◽  
Mechanical Resistance ◽  
Afm Imaging ◽  
Gel Phase ◽  
C60 Fullerenes

AFM imaging and nanoindentation complemented by FTIR and light scattering revealed the effect of intramembrane fullerene C60 on fluid and gel phase lipid bilayers.

Swing motion as a diffusion mechanism of lipid bilayers in a gel phase

2016 ◽  
Vol 93 (1) ◽  
Author(s):  
Younghoon Oh ◽  
Jeongmin Kim ◽  
Arun Yethiraj ◽  
Bong June Sung
Keyword(s):  
Lipid Bilayers ◽  
Diffusion Mechanism ◽  
Gel Phase
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