Re: Placental magnetic resonance imaging T2* measurements in normal pregnancies and in those complicated by fetal growth restriction. M. Sinding, D. A. Peters, J. B. Frøkjaer, O. B. Christiansen, A. Petersen, N. Uldbjerg and A. Sørensen. Ultrasound Obstet

2016 ◽  
Vol 47 (6) ◽  
pp. 673-673
Author(s):  
J. Wikström
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Resonance Imaging

scholarly journals Placental magnetic resonance imaging T2* measurements in normal pregnancies and in those complicated by fetal growth restriction

2016 ◽  
Vol 47 (6) ◽  
pp. 748-754 ◽  
Author(s):  
M. Sinding ◽  
D. A. Peters ◽  
J. B. Frøkjaer ◽  
O. B. Christiansen ◽  
A. Petersen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Resonance Imaging

scholarly journals Magnetic resonance imaging of hypoxic injury to the murine placenta

2010 ◽  
Vol 298 (2) ◽  
pp. R312-R319 ◽  
Author(s):  
Tracy M. Tomlinson ◽  
Joel R. Garbow ◽  
Jeff R. Anderson ◽  
John A. Engelbach ◽  
D. Michael Nelson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Parameter Analysis ◽  
Resonance Imaging ◽  
Placental Perfusion ◽  
Hypoxic Injury

We assessed the use of magnetic resonance imaging (MRI) to define placental hypoxic injury associated with fetal growth restriction. On embryonic day 18.5 (E18.5) we utilized dynamic contrast-enhanced (DCE)-MRI on a 4.7-tesla small animal scanner to examine the uptake and distribution of gadolinium-based contrast agent. Quantitative DCE parameter analysis was performed for the placenta and fetal kidneys of three groups of pregnant C57BL/6 mice: 1) mice that were exposed to FiO2 = 12% between E15.5 and E18.5, 2) mice in normoxia with food restriction similar to the intake of hypoxic mice between E15.5 and E18.5, and 3) mice in normoxia that were fed ad libitum. After imaging, we assessed fetoplacental weight, placental histology, and gene expression. We found that dams exposed to hypoxia exhibited fetal growth restriction (weight reduction by 28% and 14%, respectively, P < 0.05) with an increased placental-to-fetal ratio. By using MRI-based assessment of placental contrast agent kinetics, referenced to maternal paraspinous muscle, we found decreased placental clearance of contrast media in hypoxic mice, compared with either control group (61%, P < 0.05). This was accompanied by diminished contrast accumulation in the hypoxic fetal kidneys (23%, P < 0.05), reflecting reduced transplacental gadolinium transport. These changes were associated with increased expression of placental Phlda2 and Gcm1 transcripts. Exposure to hypoxia near the end of mouse pregnancy reduces placental perfusion and clearance of contrast. MRI-based DCE imaging provides a novel tool for dynamic, in vivo assessment of placental function.

scholarly journals Magnetic Resonance Imaging in Pregnancy with Intrauterine Growth Restriction: A Pilot Study

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Serafina Perrone ◽  
Antonino Santacroce ◽  
Giuseppe de Bernardo ◽  
Maria Gabriella Alagna ◽  
Salvatore Francesco Carbone ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Amniotic Fluid ◽  
Fetal Growth ◽  
Gestational Age ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Resonance Imaging ◽  
Intrauterine Growth ◽  
Respiratory Outcome

Objective. Intrauterine growth restriction (IUGR) is a major cause of late stillbirth, though not all compromised babies remain small or are considered growth restricted as pregnancy progresses. Fetal Magnetic Resonance Imaging (f-MRI) represents a second-line tool to study pregnancies with IUGR fetuses. The aim of our study was to evaluate the usefulness of f-MRI on predicting fetal growth and the offspring’s perinatal respiratory outcome. Design. All f-MRI performed between 2014 and 2016 in Siena were analysed. Pregnancies with IUGR (Study group (SG)) were recruited together with a control population (Control group (CG)), coupled for gestational age (GA) at the time of f-MRI (mean GA 31 wks). Neonatal information was collected. The f-MRI protocol consisted of T2w images. Six regions of interest (ROI) were placed as follows: 2 on the lung, 2 on the liver, and 2 on the amniotic fluid. The signal intensities (SI) of each ROI were measured. The SI lung to liver ratio (SI lung/liver) and SI lung to amniotic fluid ratio (SI lung/amniotic fluid) were obtained for each fetus. Each ratio was compared between SG and CG. Therefore, SG was divided into two subgroups: adequate and small for gestational age (AGA and SGA) newborns. All measurements were related to offspring’s perinatal respiratory outcome. Results. SI lung/liver was linearly related with GA at the time of f-MRI and with EFW. SI lung/amniotic fluid was significantly higher in SG than in CG (p=0,014). In contrast, among SG, lower values of SI lung/amniotic fluid were found in the SGA compared to AGA (p=0,036). The days of oxygen supply were higher in the SGA subgroup than in the AGA subgroup (p=0,028). Conclusions. SI lung/liver increases with fetal lung maturation and appears to be useful to estimate intrauterine fetal growth. SI lung/amniotic fluid seems to be a reliable predictive index to distinguish the IUGR fetuses that can recover their growth from those that were born SGA. f-MRI represents a promising frontier to predict IUGR fetus outcome, thus contributing to ameliorate the perinatal management.

scholarly journals Magnetic resonance imaging‐estimated placental perfusion in fetal growth assessment

2015 ◽  
Vol 46 (6) ◽  
pp. 700-705 ◽  
Author(s):  
S. Sohlberg ◽  
A. Mulic‐Lutvica ◽  
M. Olovsson ◽  
J. Weis ◽  
O. Axelsson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fetal Growth ◽  
Resonance Imaging ◽  
Placental Perfusion ◽  
Growth Assessment

Impact of intrauterine growth restriction and glucocorticoids on brain development: Insights using advanced magnetic resonance imaging

2006 ◽  
Vol 254-255 ◽  
pp. 163-171 ◽  
Author(s):  
Stéphane V. Sizonenko ◽  
Cristina Borradori-Tolsa ◽  
Delphine M. Vauthay ◽  
Gregory Lodygensky ◽  
François Lazeyras ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Development ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Resonance Imaging ◽  
Intrauterine Growth
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