scholarly journals Magnetic resonance imaging‐estimated placental perfusion in fetal growth assessment

2015 ◽  
Vol 46 (6) ◽  
pp. 700-705 ◽  
Author(s):  
S. Sohlberg ◽  
A. Mulic‐Lutvica ◽  
M. Olovsson ◽  
J. Weis ◽  
O. Axelsson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fetal Growth ◽  
Resonance Imaging ◽  
Placental Perfusion ◽  
Growth Assessment

scholarly journals Magnetic resonance imaging of hypoxic injury to the murine placenta

2010 ◽  
Vol 298 (2) ◽  
pp. R312-R319 ◽  
Author(s):  
Tracy M. Tomlinson ◽  
Joel R. Garbow ◽  
Jeff R. Anderson ◽  
John A. Engelbach ◽  
D. Michael Nelson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Parameter Analysis ◽  
Resonance Imaging ◽  
Placental Perfusion ◽  
Hypoxic Injury

We assessed the use of magnetic resonance imaging (MRI) to define placental hypoxic injury associated with fetal growth restriction. On embryonic day 18.5 (E18.5) we utilized dynamic contrast-enhanced (DCE)-MRI on a 4.7-tesla small animal scanner to examine the uptake and distribution of gadolinium-based contrast agent. Quantitative DCE parameter analysis was performed for the placenta and fetal kidneys of three groups of pregnant C57BL/6 mice: 1) mice that were exposed to FiO2 = 12% between E15.5 and E18.5, 2) mice in normoxia with food restriction similar to the intake of hypoxic mice between E15.5 and E18.5, and 3) mice in normoxia that were fed ad libitum. After imaging, we assessed fetoplacental weight, placental histology, and gene expression. We found that dams exposed to hypoxia exhibited fetal growth restriction (weight reduction by 28% and 14%, respectively, P < 0.05) with an increased placental-to-fetal ratio. By using MRI-based assessment of placental contrast agent kinetics, referenced to maternal paraspinous muscle, we found decreased placental clearance of contrast media in hypoxic mice, compared with either control group (61%, P < 0.05). This was accompanied by diminished contrast accumulation in the hypoxic fetal kidneys (23%, P < 0.05), reflecting reduced transplacental gadolinium transport. These changes were associated with increased expression of placental Phlda2 and Gcm1 transcripts. Exposure to hypoxia near the end of mouse pregnancy reduces placental perfusion and clearance of contrast. MRI-based DCE imaging provides a novel tool for dynamic, in vivo assessment of placental function.

scholarly journals A longitudinal study of placental perfusion using dynamic contrast enhanced magnetic resonance imaging in murine pregnancy

Placenta ◽  
2016 ◽  
Vol 43 ◽  
pp. 90-97 ◽  
Author(s):  
Brijesh Kumar Yadav ◽  
Jaladhar Neelavalli ◽  
Uday Krishnamurthy ◽  
Gabor Szalai ◽  
Yimin Shen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Longitudinal Study ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Placental Perfusion ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Murine Pregnancy

scholarly journals Placental magnetic resonance imaging T2* measurements in normal pregnancies and in those complicated by fetal growth restriction

2016 ◽  
Vol 47 (6) ◽  
pp. 748-754 ◽  
Author(s):  
M. Sinding ◽  
D. A. Peters ◽  
J. B. Frøkjaer ◽  
O. B. Christiansen ◽  
A. Petersen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Resonance Imaging

scholarly journals The application of in utero magnetic resonance imaging in the study of the metabolic and cardiovascular consequences of the developmental origins of health and disease

2020 ◽  
pp. 1-10
Author(s):  
Stephanie A. Giza ◽  
Simran Sethi ◽  
Lauren M. Smith ◽  
Mary-Ellen E. T. Empey ◽  
Lindsay E. Morris ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adipose Tissue ◽  
Magnetic Resonance ◽  
Fetal Growth ◽  
Fetal Development ◽  
In Utero ◽  
Developmental Origins ◽  
Organ Development ◽  
Resonance Imaging ◽  
Health And Disease

Abstract Observing fetal development in utero is vital to further the understanding of later-life diseases. Magnetic resonance imaging (MRI) offers a tool for obtaining a wealth of information about fetal growth, development, and programming not previously available using other methods. This review provides an overview of MRI techniques used to investigate the metabolic and cardiovascular consequences of the developmental origins of health and disease (DOHaD) hypothesis. These methods add to the understanding of the developing fetus by examining fetal growth and organ development, adipose tissue and body composition, fetal oximetry, placental microstructure, diffusion, perfusion, flow, and metabolism. MRI assessment of fetal growth, organ development, metabolism, and the amount of fetal adipose tissue could give early indicators of abnormal fetal development. Noninvasive fetal oximetry can accurately measure placental and fetal oxygenation, which improves current knowledge on placental function. Additionally, measuring deficiencies in the placenta’s transport of nutrients and oxygen is critical for optimizing treatment. Overall, the detailed structural and functional information provided by MRI is valuable in guiding future investigations of DOHaD.

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