Genetic research and structural dysplasia assessment of anorectal malformations in neonatal male rats induced by di(n-butyl) phthalate

2014 ◽  
Vol 31 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Zhi-Hong Liu ◽  
En-Hui Li ◽  
Dong-Liang Xu ◽  
Wen-Lan Sun ◽  
Yan Hong ◽  
...  
Keyword(s):  
Genetic Research ◽  
Anorectal Malformations ◽  
Male Rats ◽  
Butyl Phthalate

Protective effects of Lactobacillus plantarum strain P1 against toxicity of the environmental oestrogen di-n-butyl phthalate in rats

2020 ◽  
Vol 11 (8) ◽  
pp. 803-813
Author(s):  
X. Shi ◽  
C. Hu ◽  
S. Cai ◽  
X. Tao ◽  
Y. Zhou ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactobacillus Plantarum ◽  
Therapeutic Strategy ◽  
Male Rats ◽  
Protective Effects ◽  
Oral Gavage ◽  
Butyl Phthalate ◽  
Maize Oil

Phthalates are contaminants widely distributed in the food-chain, and they are considered as important environmental oestrogens in our lives. In the present study, eight strains of lactic acid bacteria were isolated for their ability to adsorb di-n-butyl-phthalate (DBP), and one of the strains, Lactobacillus plantarum strain P1, was selected for more detailed analyses of its phthalate adsorption capacity in vitro. This study also evaluated the in vivo protective effects of strain P1 against DBP toxicity in rats. Sixteen rats were divided into four groups, and animals received by oral gavage every other day for a period of one month saline with or without strain P1 at 2×1011 cfu/kg followed by maize oil with or without DBP (50 mg/kg). Strain P1 could adsorb more DBP than saline alone, and the concentration of mono-n-butyl phthalate in urine was decreased in animals receiving P1. Furthermore, oestrogenic effects of the different treatments were assessed through counting of sperm and observation of testis, and strain P1 could protect the sexual organs of male rats. Our results suggested that P1 is effective against phthalate toxicity due to its ability to adsorb DBP in vivo and could be considered as a new dietary therapeutic strategy against environmental phtalate toxicity.

Prenatal di-n-butyl phthalate exposure alters reproductive functions at adulthood in male rats

2012 ◽  
Vol 29 (5) ◽  
pp. 534-544 ◽  
Author(s):  
Nelli Giribabu ◽  
Sri Bhashyam Sainath ◽  
Pamanji Sreenivasula Reddy
Keyword(s):  
Male Rats ◽  
Phthalate Exposure ◽  
Butyl Phthalate

Functional and Morphological Reproductive Aspects in Male Rats Exposed to Di-n-Butyl Phthalate (DBP) in Utero and During Lactation

2010 ◽  
Vol 73 (13-14) ◽  
pp. 972-984 ◽  
Author(s):  
Wellerson R. Scarano ◽  
Fabíola C. Toledo ◽  
Marina T. Guerra ◽  
Patrícia F. F. Pinheiro ◽  
Raquel F. Domeniconi ◽  
...  
Keyword(s):  
In Utero ◽  
Male Rats ◽  
Butyl Phthalate

Taxifolin attenuates the developmental testicular toxicity induced by di-n-butyl phthalate in fetal male rats

2020 ◽  
Vol 142 ◽  
pp. 111482
Author(s):  
Zengqiang Li ◽  
Yige Yu ◽  
Yang Li ◽  
Feifei Ma ◽  
Yinghui Fang ◽  
...  
Keyword(s):  
Male Rats ◽  
Testicular Toxicity ◽  
Butyl Phthalate

scholarly journals Expression of the Shh/Bmp4 signaling pathway during the development of anorectal malformations in a male rat model of prenatal exposure to di(n-butyl) phthalate

2015 ◽  
Vol 4 (2) ◽  
pp. 241-247 ◽  
Author(s):  
En-Hui Li ◽  
Sheng-Jie Liang ◽  
Wen-Lan Sun ◽  
Dong-Liang Xu ◽  
Yan Hong ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Prenatal Exposure ◽  
Rat Model ◽  
Anorectal Malformations ◽  
Male Rat ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein ◽  
Butyl Phthalate

Sonic hedgehog (Shh)/bone morphogenetic protein 4 (Bmp4) is an androgen-regulated signaling pathway that has been shown to be crucial for embryonic development.

Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP)

Toxicology ◽  
2009 ◽  
Vol 260 (1-3) ◽  
pp. 120-125 ◽  
Author(s):  
Ying-Jian Zhu ◽  
Jun-Tao Jiang ◽  
Long Ma ◽  
Jie Zhang ◽  
Yan Hong ◽  
...  
Keyword(s):  
In Utero ◽  
Male Rats ◽  
In Utero Exposure ◽  
Butyl Phthalate
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